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From:PLoS ONE (Vol. 16, Issue 2) Peer-ReviewedElevated reactive oxygen species (ROS) in type 2 diabetes cause cellular damage in many organs. Recently, the new class of glucose-lowering agents, SGLT-2 inhibitors, have been shown to reduce the risk of developing...
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From:Nature (Vol. 451, Issue 7174) Peer-ReviewedMammalian homologues of Drosophila melanogaster transient receptor potential (TRP) are a large family of multimeric cation channels that act, or putatively act, as sensors of one or more chemical factor (1,2). Major...
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From:Nature Biotechnology (Vol. 23, Issue 10) Peer-ReviewedHere we describe a strategy for generating ion-channel inhibitors. It takes advantage of antibody specificity combined with a pattern recognition approach that targets the third extracellular region (E3) of a channel....
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From:Nature (Vol. 451, Issue 7174) Peer-ReviewedAuthor(s): Shang-Zhong Xu [1, 4, 5]; Piruthivi Sukumar [1, 4]; Fanning Zeng [1]; Jing Li [1]; Amit Jairaman [1]; Anne English [3]; Jacqueline Naylor [1]; Coziana Ciurtin [1]; Yasser Majeed [1]; Carol J. Milligan [1];...
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From:JAMA, The Journal of the American Medical Association (Vol. 278, Issue 16) Peer-ReviewedCitation Only