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From:Alzheimer's Research & Therapy (Vol. 12, Issue 1) Peer-ReviewedBackground Plasma neurofilament light (NFL) and total Tau (t-Tau) proteins are candidate biomarkers for early stages of Alzheimer's disease (AD). The impact of biological factors on their plasma concentrations in...
From:PLoS ONE (Vol. 16, Issue 1) Peer-ReviewedThe traditional approach to biomarker discovery for any pathology has been through hypothesis-based research one candidate at a time. The objective of this study was to develop an agnostic approach for the simultaneous...
From:Trends in NeurosciencesPeer-ReviewedAbstract Only
From:Alzheimer's Research & Therapy (Vol. 12, Issue 1) Peer-Reviewed[beta]-Secretase1 (BACE1) protein concentrations and rates of enzyme activity, analyzed in human bodily fluids, are promising candidate biological markers for guidance in clinical trials investigating BACE1 inhibitors...
From:Biomarkers in Medicine (Vol. 5, Issue 4) Peer-ReviewedAuthor(s): Simone Lista [[dagger]] 1 , Enzo Emanuele 2 KEYWORDS : Alzheimer's disease; amyloid [beta]Î²1-42; amyloid plaques; biomarker; cerebrospinal fluid; mild cognitive impairment; MRI Recent years have...
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