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From:Gene Therapy (Vol. 26, Issue 6) Peer-ReviewedRecombinant Adeno-associated viruses (AAVs) are an attractive vector for gene therapy delivery which may be blocked by AAV neutralising antibodies (NAbs). As Type 1 Diabetes (T1DM) is an endocrine disease of...
From:Gene Therapy (Vol. 28, Issue 5) Peer-ReviewedNeutralising antibodies (NAbs), caused by past adeno-associated virus (AAV) infection, represent a critical challenge for AAV-mediated gene therapy, with even low NAb titres capable of inhibiting gene transfer, however...
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