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From:PLoS ONE (Vol. 10, Issue 9) Peer-ReviewedBackground Non-steroidal anti-inflammatory drug (NSAID) use is associated with decreased risk of some cancers. NSAID use modulates the epigenetic profile of normal colonic epithelium and may reduce risk of colon...
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From:Environmental Health Perspectives (Vol. 122, Issue 7) Peer-ReviewedBackground: Smoking increases the risk of many diseases, and it is also linked to blood DNA methylation changes that may be important in disease etiology. Objectives: We sought to identify novel CpG sites associated...
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From:PLoS ONE (Vol. 11, Issue 7) Peer-ReviewedOffspring of older mothers are at increased risk of adverse birth outcomes, childhood cancers, type 1 diabetes, and neurodevelopmental disorders. The underlying biologic mechanisms for most of these associations remain...
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From:Environmental Health Perspectives (Vol. 125, Issue 3) Peer-ReviewedBACKGROUND: Early-life exposure to estrogenic compounds affects the development of the reproductive system in rodent models and humans. Soy products, which contain phytoestrogens such as genistein, are one source of...
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From:Environmental Health Perspectives (Vol. 122, Issue 10) Peer-ReviewedBackground: Maternal smoking during pregnancy is associated with significant infant morbidity and mortality, and may influence later disease risk. One mechanism by which smoking (and other environmental factors) might...
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From:PLoS ONE (Vol. 14, Issue 4) Peer-ReviewedPurpose Inflammation-related mechanisms may contribute to the link between diet and cancer. We sought to investigate the inflammatory impact of diet on cancer risk using the Dietary inflammatory index (DII) and an...
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From:PLoS ONE (Vol. 10, Issue 3) Peer-ReviewedIn utero exposure to diethylstilbestrol (DES) has been associated with increased risk of adverse health outcomes such as fertility problems and vaginal as well as breast cancer. Animal studies have linked prenatal DES...
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From:BMC Research Notes (Vol. 5, Issue 1) Peer-ReviewedBackground Recent studies have identified several single-nucleotide polymorphisms (SNPs) associated with the risk of breast cancer and parity and age at first childbirth are well established and important risk...