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    Academic Journals

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• Clinicopathologic significance of the CXCL1-CXCR2 axis in the tumor microenvironment of gastric carcinoma

  Authors:Hiroaki Kasashima, Masakazu Yashiro, Hirohisa Nakamae, Go Masuda, Haruhito Kinoshita, Tamami Morisaki, et al.From:PLoS ONE (Vol. 12, Issue 6) Peer-Reviewed

  June 2, 20174,121 words Report 1500LPurpose It was reported that the chemokine (C-X-C motif) ligand 1 (CXCL1) from cancer cells stimulated the recruitment of bone marrow-derived mesenchymal cells (BM-MCs) into tumor stroma via chemokine (C-X-C motif)...

• Abundant intratumoral fibrosis prevents lymphocyte infiltration into peritoneal metastases of colorectal cancer.

  Authors:En Wang, Masatsune Shibutani, Hisashi Nagahara, Tatsunari Fukuoka, Yasuhito Iseki, Yuki Okazaki, et al.From:PLoS ONE (Vol. 16, Issue 7) Peer-Reviewed

  July 22, 20216,928 words Report 1510LBackground Tumor-infiltrating lymphocytes (TILs) have been reported to reflect the anti-tumor immune status. However, recent investigations have demonstrated that intratumoral fibrosis is important as a factor...

• Pancreatic Fibroblasts Stimulate the Motility of Pancreatic Cancer Cells through IGF1/IGF1R Signaling under Hypoxia

  Authors:Toshiki Hirakawa, Masakazu Yashiro, Yosuke Doi, Haruhito Kinoshita, Tamami Morisaki, Tatsunari Fukuoka, et al.From:PLoS ONE (Vol. 11, Issue 8) Peer-Reviewed

  Aug. 3, 20165,987 words Article 1360LPancreatic ductal adenocarcinoma (PDAC) is characterized by its hypovascularity, with an extremely poor prognosis because of its highly invasive nature. PDAC proliferates with abundant stromal cells, suggesting that its...

• Comparative Proteomics Analysis of Gastric Cancer Stem Cells

  Authors:Tamami Morisaki, Masakazu Yashiro, Anna Kakehashi, Azusa Inagaki, Haruhito Kinoshita, Tatsunari Fukuoka, et al.From:PLoS ONE (Vol. 9, Issue 11) Peer-Reviewed

  Nov. 7, 20148,038 words Article 1470LCancer stem cells (CSCs) are responsible for cancer progression, metastasis, and recurrence. To date, the specific markers of CSCs remain undiscovered. The aim of this study was to identify novel biomarkers of gastric...

• A new method for evaluating tumor-infiltrating lymphocytes (TILs) in colorectal cancer using hematoxylin and eosin (H-E)-stained tumor sections

  Authors:Yasuhito Iseki, Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shinji Matsutani, et al.From:PLoS ONE (Vol. 13, Issue 4) Peer-Reviewed

  Apr. 26, 20184,338 words Report 1320LPurpose Numerous reports indicate that tumor-infiltrating lymphocytes (TILs) are a prognostic factor in various cancers and that they must be good biomarkers. However, the methods of evaluating TILs differ in each...

• Novel prognostic biomarkers of pouchitis after ileal pouch-anal anastomosis for ulcerative colitis: Neutrophil-to-lymphocyte ratio

  Authors:Yu Nishida, Shuhei Hosomi, Hirokazu Yamagami, Koji Fujimoto, Rieko Nakata, Shigehiro Itani, et al.From:PLoS ONE (Vol. 15, Issue 10) Peer-Reviewed

  Oct. 26, 20205,004 words Report 1380LObjectives Pouchitis is a major complication after restorative proctocolectomy with ileal pouch-anal anastomosis (IPAA) in patients with ulcerative colitis (UC). Although there have been many investigations of the...