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From:PLoS ONE (Vol. 16, Issue 4) Peer-ReviewedThe blood-brain barrier (BBB) is one of the main obstacles for therapies targeting brain diseases. Most macromolecules fail to pass the tight BBB, formed by brain endothelial cells interlinked by tight junctions. A wide...
From:PLoS ONE (Vol. 9, Issue 10) Peer-ReviewedBackground Acylation of peptide drugs with fatty acid chains has proven beneficial for prolonging systemic circulation as well as increasing enzymatic stability without disrupting biological potency. Acylation has...
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