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    Academic Journals

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• Maintenance of self-renewal and pluripotency in J1 mouse embryonic stem cells through regulating transcription factor and MicroRNA expression induced by PD0325901

  Authors:Zhiying Ai, Jingjing Shao, Xinglong Shi, Mengying Yu, Yongyan Wu, Juan Du, et al.From:Stem Cells InternationalPeer-Reviewed

  Annual 20156,816 words Article 1480LEmbryonic stem cells (ESCs) have the ability to grow indefinitely and retain their pluripotency in culture, and this self-renewal capacity is governed by several crucial molecular pathways controlled by specific...

• CPSF6 links alternative polyadenylation to metabolism adaption in hepatocellular carcinoma progression.

  Authors:Sheng Tan, Ming Zhang, Xinglong Shi, Keshuo Ding, Qiang Zhao, Qianying Guo, et al.From:Journal of Experimental & Clinical Cancer Research (Vol. 40, Issue 1) Peer-Reviewed

  Mar. 1, 20217,188 words Article 1580LBackground Alternative polyadenylation (APA) is an important mechanism of gene expression regulation through generation of RNA isoforms with distinct 3' termini. Increasing evidence has revealed that APA is actively...

• CHIR99021 enhances Klf4 Expression through [beta]-Catenin Signaling and miR-7a Regulation in J1 Mouse Embryonic Stem Cells

  Authors:Zhiying Ai, Jingjing Shao, Yongyan Wu, Mengying Yu, Juan Du, Xiaoyan Shi, et al.From:PLoS ONE (Vol. 11, Issue 3) Peer-Reviewed

  Mar. 3, 20168,783 words Article 1340LUnderstanding the mechanisms that regulate pluripotency of embryonic stem cells (ESCs) is important to ensure their safe clinical use. CHIR99021 (CHIR)-induced activation of Wnt/[beta]-catenin signaling promotes...