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From:International Journal of Endocrinology (Vol. 2022) Peer-ReviewedSestrin2 is a highly conserved stress-inducible protein, acting as a crucial part in regulating homeostasis in response to various stress conditions in the cell. However, the role of Sestrin2 in regulating cell apoptosis...
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From:PeerJ (Vol. 10) Peer-ReviewedThis work explored the mechanism of the effect of breast-cancer susceptibility gene 1 (BRCA1) on the metabolic characteristics of breast cancer cells, including the Warburg effect and its specific signaling. We...
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From:Archives of Pathology & Laboratory Medicine (Vol. 146, Issue 8) Peer-ReviewedContext.--Nonalcoholic fatty liver disease (NAFLD) encompasses steatosis and steatohepatitis. The cause may be multifactorial, and diagnosis requires correlation with clinical information and laboratory results....
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From:PLoS ONE (Vol. 17, Issue 7) Peer-ReviewedMetformin is a traditional anti-hyperglycemic medication that has recently been shown to benefit vascular complications of diabetes via an anti-inflammatory mechanism other than glycemic control. This study aims to test...
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From:Archives of Pathology & Laboratory Medicine (Vol. 136, Issue 3) Peer-ReviewedWe report the first case, to our knowledge, of a possible primary, signet-ring cell melanoma of the gastroesophageal junction. The mass was initially diagnosed as an invasive, poorly differentiated carcinoma; however,...
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From:Trends in Biochemical Sciences (Vol. 40, Issue 9) Peer-Reviewed
Ready, pause, go: regulation of RNA polymerase II pausing and release by cellular signaling pathways
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From:Journal of Clinical Investigation (Vol. 129, Issue 4) Peer-ReviewedMucus-invasive bacterial biofilms are identified on the colon mucosa of approximately 50% of colorectal cancer (CRC) patients and approximately 13% of healthy subjects. Here, we test the hypothesis that human colon...
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From:Archives of Pathology & Laboratory Medicine (Vol. 132, Issue 11) Peer-ReviewedIn this report, we describe a 36-year-old man with the synchronous occurrence of multiple gastric gastrointestinal stromal tumors and multiple intestinal lipomas. Multiple, small, and well-circumscribed gastric...
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From:Archives of Pathology & Laboratory Medicine (Vol. 142, Issue 4) Peer-ReviewedContext.--Isolated loss of PMS2 staining is an uncommon immunophenotype in colorectal carcinomas, accounting for approximately 4% of tumors with microsatellite instability. Limited information regarding these tumors is...
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From:Emerging Infectious Diseases (Vol. 11, Issue 3) Peer-ReviewedSevere acute respiratory syndrome-associated coronavirus (SARS-CoV) was isolated from a pig during a survey for possible routes of viral transmission after a SARS epidemic. Sequence and epidemiology analyses suggested...
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From:Journal of Experimental & Clinical Cancer Research (Vol. 28) Peer-ReviewedAuthors: Lijun Tan [1]; Jiangtao Liu [2]; Xiuli Liu [1]; Jie Chen [1]; Zhijun Yan [1]; Huifen Yang [1]; Daxin Zhang (corresponding author) [1] Background Chemotherapy-induced nausea and vomiting is a significant...
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From:Archives of Pathology & Laboratory Medicine (Vol. 140, Issue 5) Peer-Reviewed* Context.--Idiopathic inflammatory bowel disease manifests with different clinical phenotypes showing varying behavior and risk for neoplasia. The clinical questions that are posed to pathologists differ depending on...
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From:PLoS ONE (Vol. 13, Issue 3) Peer-ReviewedAuthor(s): Jing Han 1,2, Yue Li 1, Xiuli Liu 1, Tongrong Zhou 1, Haijing Sun 3, Paul Edwards 1, Hua Gao 1, Fu-Shin Yu 3, Xiaoxi Qiao 1,* Introduction Diabetic retinopathy (DR) is the leading cause of irreversible...
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From:PeerJ (Vol. 9) Peer-ReviewedAquaporins (AQPs) are a class of highly conserved integral membrane proteins that facilitate the uptake and transport of water and other small molecules across cell membranes. However, little is known about AQP genes in...
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From:PLoS ONE (Vol. 10, Issue 5) Peer-ReviewedCardiovascular disease (CVD) is a serious comorbidity in nonalcoholic fatty liver disease (NAFLD). Since plasma ceramides are increased in NAFLD and sphingomyelin, a ceramide metabolite, is an independent risk factor...
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From:PLoS ONE (Vol. 12, Issue 11) Peer-ReviewedBackground Seafarers have reported impaired health and health-related quality of life (HRQOL). Social support might increase HRQOL, but little is known about this association among Chinese seafarers. The aim of this...
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From:Archives of Pathology & Laboratory Medicine (Vol. 131, Issue 9) Peer-Reviewed* Although mucoepidermoid carcinoma of the salivary gland is relatively common, mucoepidermoid carcinoma arising from the mucous glands of the bronchus is rare. Bronchial mucoepidermoid carcinoma usually presents as an...