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    Academic Journals

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• Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration.

  Authors:Tara E. Tracy, Jesus Madero-Pérez, Danielle L. Swaney, Timothy S. Chang, Michelle Moritz, Csaba Konrad, et al.From:Cell (Vol. 185, Issue 4) Peer-Reviewed

  Feb. 17, 2022546 words Report

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• Progranulin protects against amyloid [beta] deposition and toxicity in Alzheimer's disease mouse models

  Authors:S. Sakura Minami, Sang-Won Min, Grietje Krabbe, Chao Wang, Yungui Zhou, Rustam Asgarov, et al.From:Nature Medicine (Vol. 20, Issue 10) Peer-Reviewed

  Oct. 20148,405 words Report 1450LHaploinsufficiency of the progranulin (PGRN) gene (GRN) causes familial frontotemporal lobar degeneration (FTLD) and modulates an innate immune response in humans and in mouse models. GRN polymorphism may be linked to...

• Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

  Authors:Faten A. Sayed, Maria Telpoukhovskaia, Lay Kodama, Yaqiao Li, Yungui Zhou, David Le, et al.From:Proceedings of the National Academy of Sciences of the United States (Vol. 115, Issue 40) Peer-Reviewed

  Oct. 2, 20186,186 words Report 1420L

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• A MAC2-positive progenitor-like microglial population is resistant to CSF1R inhibition in adult mouse brain

  Authors:Lihong Zhan, Li Fan, Lay Kodama, Peter Dongmin Sohn, Man Ying Wong, Gergey Alzaem Mousa, et al.From:eLife (Vol. 9) Peer-Reviewed

  Oct. 15, 202018,273 words Report 1470LMicroglia are the resident myeloid cells in the central nervous system (CNS). The majority of microglia rely on CSF1R signaling for survival. However, a small subset of microglia in mouse brains can survive without...

• Critical role of acetylation in tau-mediated neurodegeneration and cognitive deficits

  Authors:Sang-Won Min, Xu Chen, Tara E. Tracy, Yaqiao Li, Yungui Zhou, Chao Wang, et al.From:Nature Medicine (Vol. 21, Issue 10) Peer-Reviewed

  Oct. 20159,919 words Report 1400LTauopathies, including frontotemporal dementia (FTD) and Alzheimer's disease (AD), are neurodegenerative diseases in which tau fibrils accumulate. Recent evidence supports soluble tau species as the major toxic species....