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From:Cell (Vol. 185, Issue 4) Peer-ReviewedAbstract Only
From:Nature Medicine (Vol. 20, Issue 10) Peer-ReviewedHaploinsufficiency of the progranulin (PGRN) gene (GRN) causes familial frontotemporal lobar degeneration (FTLD) and modulates an innate immune response in humans and in mouse models. GRN polymorphism may be linked to...
From:Proceedings of the National Academy of Sciences of the United States (Vol. 115, Issue 40) Peer-ReviewedAbstract Only
From:eLife (Vol. 9) Peer-ReviewedMicroglia are the resident myeloid cells in the central nervous system (CNS). The majority of microglia rely on CSF1R signaling for survival. However, a small subset of microglia in mouse brains can survive without...
From:Nature Medicine (Vol. 21, Issue 10) Peer-ReviewedTauopathies, including frontotemporal dementia (FTD) and Alzheimer's disease (AD), are neurodegenerative diseases in which tau fibrils accumulate. Recent evidence supports soluble tau species as the major toxic species....
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