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From:PLoS ONE (Vol. 6, Issue 11) Peer-ReviewedSevere ocular surface diseases are some of the most challenging problems that the clinician faces today. Conventional management is generally unsatisfactory, and the long-term ocular consequences of these conditions are...
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From:Oxidative Medicine and Cellular Longevity (Vol. 2015) Peer-ReviewedReactive oxygen species (ROS) are closely related to tumorgenesis. Under hypoxic environment, increased levels of ROS induce the expression of hypoxia inducible factors (HIFs) in cancer stem cells (CSCs), resulting in...
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From:PLoS ONE (Vol. 9, Issue 4) Peer-ReviewedTo construct an auto-tissue-engineered lamellar cornea (ATELC) for transplantation, based on acellular porcine corneal stroma and autologous corneal limbal explants, a dynamic culture process, which composed of a...
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From:Stem Cell Research & Therapy (Vol. 11, Issue 1) Peer-ReviewedBackground Retinal pigment epithelium (RPE) replacement has been proposed as an efficacious treatment for age-related macular degeneration (AMD), which is the primary cause of vision loss in the elderly worldwide. The...
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From:PLoS ONE (Vol. 7, Issue 3) Peer-ReviewedAuthor(s): Chaoyang Li 1 , Yiyue Song 2 , Shaohong Luan 1 , Pengxia Wan 1 , 2 , Naiyang Li 1 , Jing Tang 3 , Yu Han 3 , Cuiju Xiong 1 , Zhichong Wang 1 , 2 , * Introduction Dry eye is a common disease worldwide...
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From:Oxidative Medicine and Cellular LongevityPeer-ReviewedAge-related macular degeneration (AMD) is a blinding disease caused by multiple factors and is the primary cause of vision loss in the elderly. The morbidity of AMD increases every year. Currently, there is no effective...
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From:PLoS ONE (Vol. 9, Issue 12) Peer-ReviewedObjective To understand the prevalence and demographic characteristics of infectious keratitis and infectious corneal blindness. Methods A multi-center, population-based cross-sectional study was conducted from...
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From:PLoS ONE (Vol. 8, Issue 1) Peer-ReviewedOur previous work had found that telomerase rejuvenated in the cytoplasm of corneal epithelial cells cultured in embryonic stem cell-conditioned medium, the functional properties of stem-like corneal epithelial cells...