A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle.

Authors: Lauren M. Sparks, Hui Xie, Robert A. Koza, Randall Mynatt, Matthew W. Hulver and George A. Bray
Date: July 2005
From: Diabetes(Vol. 54, Issue 7)
Publisher: American Diabetes Association
Document Type: Article
Length: 5,404 words
Abstract :

Obesity and type 2 diabetes have been associated with a high-fat diet (HFD) and reduced mitochondrial mass and function. We hypothesized a HFD may affect expression of genes involved in mitochondrial function and biogenesis. To test this hypothesis, we fed 10 insulin-sensitive males an isoenergetic HFD for 3 days with muscle biopsies before and after intervention. Oligonucleotide microarray analysis revealed 297 genes were differentially regulated by the HFD (Bonferonni adjusted P
Source Citation
Sparks, Lauren M., et al. "A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle." Diabetes, vol. 54, no. 7, July 2005, pp. 1926+. link.gale.com/apps/doc/A134380159/AONE?u=gale&sid=bookmark-AONE. Accessed 1 Mar. 2026.
  

Gale Document Number: GALE|A134380159