Thorough washing with soap is the first step in treating poison ivy rash. Acute dermatitis can be managed with cold compresses of saline or Burrow's solution. Anhistamines can be administered in cases of discomfort or severe itching, while the affected area, especially if small, can be applied with plain calamine lotion or corticosteroid cream. Systemic corticosteroid therapy is prescribed if the rash has affected the face, hands or a large area of the body.