Plasminogen activator inhibitor-1 (PAI-1) has been found to affect a number of important cell processes and therefore abnormal expression of PAI-1 has been associated with a number of diseases and disorders. Understanding the transactivation of PAI-1 may result in identifying novel therapeutic targets. Keywords: PAI-1, EGFR, TGF-[beta]1, apoptosis, angiogenesis, tubulogenesis
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