Frequency of respiratory viruses in children with lower respiratory tract infection/Alt solunum yolu enfeksiyonu olan cocuklarda solunum yolu viral etkenlerinin sikligi

Citation metadata

Authors: Sinem Akcali, Nisel Yilmaz, Ozlem Guler, Tamer Sanlidag and Murat Anil
Date: Sept. 2013
From: Turkish Pediatrics Archive(Vol. 48, Issue 3)
Publisher: AVES
Document Type: Report
Length: 3,335 words

Main content

Article Preview :

Summary

Aim: Lower respiratory tract infections (LRTI) have high morbidity rates in children. In this study, it was aimed to investigate the prevalence of respiratory viruses in children with LRTI symptoms.

Material and Method: A total of 160 children who were diagnosed with LRTI between October 2009 and March 2010 were included into the study. The presence of respiratory syncytial virus (RSV) (A+B), influenza virus (A+B), parainfluenza virus (PIV) (1, 2, 3, 4), human metapneumovirus, rhinovirus and coronavirus (OC43+229E) in throat swab samples were investigated by real-time PCR The RealAccurateTM Respiratory RT PCR Kit (PathoFinder B.V., Netherlands).

Results: In 67 samples (41.8%), at least one virus which could cause acute respiratory tract infection was found. Overall, RSV was the most frequently identified virus (52.2%), followed by rhinovirus (26.8%), coronavirus (5%), metapneumovirus (2.9%) and PIV 1 (1.4%). As the other viral agents, coronavirus was detected in 4 samples (5%), hMPV was detected in 2 samples (2.9%) and PIV was detected in 1 sample (1.4%). When the frequency of coinfections was evaluated, RSV- rhinovirus association was found in 4 samples, RSV-coronavirus association was found in 1 sample, rhinovirus-coronavirus association was found in 1 sample and RSV-rhinovirus-Coronavirus association was found in 1 sample.

Conclusions: In 41.8% of the study group, a viral factor responsible for the clinical signs was detected. For that reason, rapid and sensitive diagnosis of viruses which lead to respiratory infections will guide the clinician for avoidance of redundant antibiotic therapy and preventing viral hospital infections. (Turk Arch Ped 2013; 48:215-20)

Key words: Children, respiratory tract infections, real-time PCR, viruses

Ozet

Amac: Alt solunum yolu enfeksiyonlari cocuklarda sik gorulur ve ozellikle erken cocukluk caginda olum orani yuksektir. Bu arastirmada bolgemizde alt solunum yolu enfeksiyonlari belirlileri bulunan cocuklarda solunum yolu viral etkenlerinin sikliginin belirlenmesi amaclanmistir.

Gerec ve Yontem: Calisma grubu Ekim 2009-Mart 2010 tarihleri arasinda, alt solunum yolu enfeksiyonlari belirtileri ile hastaneye basvuran 160 cocuktan (ort. 14,6 ay) olusturulmustur. Bu cocuklardan alinan bogaz suruntu orneklerinde respiratuar sinsityal virus (A+B), influenza virus (A+B), parainfluenza virus (1, 2, 3, 4), insan metapnomovirus, rinovirus ve koronavirus (OC43+229E) varligi real-time PCR yontemiyle [The RealAccurate [TM] Respiratory RT PCR Kit (PathoFinder BV, Hollanda)] arastirilmistir.

Bulgular: Orneklerin 67'sinde (%41,8) alt solunum yolu enfeksiyonlari belirtilerine neden olabilecek bir viral etken saptanmistir. Respiratuar sinsityal virus %61,2'lik oranla (41/67) en sik saptanan virus olmustur. Bunu %35,8 (24/67) ile rinovirusler izlemektedir. Dort ornekte (%5) koronavirus, iki ornekte (%2,9) "insan metapnomovirus", bir ornekte de (%1,4) parainfluenza virus diger viral etkenler olarak belirlenmistir. Birlikte enfeksiyon sikliklari degerlendirildiginde, dort ornekte respiratuar sinsityal virus-rinovirus birlikteligi, bir ornekte respiratuar sinsityal virus-koronavirus birlikteligi, bir ornekte rinovirus-koronavirus birlikteligi, bir ornekte de respiratuar sinsityal virus-rinovirus-koronavirus birlikteligi saptanmistir.

Cikarimlar: Calisma grubunun %41,8'inde klinik belirtilerden sorumlu olabilecek bir viral etken saptanmistir. Bu nedenle viral solunum yolu enfeksiyonlarina neden olan viruslerin hizli ve duyarli tanisi gereksiz antibiyotik kullaniminin engellenebilmesi ve bu viruslerin neden olabilecekleri hastane enfeksiyonlarinin onlenebilmesi acisindan klinisyene yol gosterici olacaktir. (Turk Ped Ars 2013; 48:215-20)

Anahtar sozcukler: Cocuk, solunum yolu enfeksiyonlari, real-time PCR, virusler

Giris

Alt solunum yolu enfeksiyonlari (ASYE)...

Source Citation

Source Citation
Akcali, Sinem, et al. "Frequency of respiratory viruses in children with lower respiratory tract infection/Alt solunum yolu enfeksiyonu olan cocuklarda solunum yolu viral etkenlerinin sikligi." Turkish Pediatrics Archive, vol. 48, no. 3, 2013, p. 215+. Accessed 27 Oct. 2020.
  

Gale Document Number: GALE|A351429326