Absence of anthelmintic activity of hydroalcoholic leaf extracts of Artabotrys hexapetalus (Linn.f)

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Authors: M. Vasundhara, Y. Karthik, K. Anjali, C. Chithra, Priyanka Gupta and C. Roopa
Date: January-December 2014
From: Journal of Pharmaceutical Negative Results(Vol. 5, Issue 1)
Publisher: Medknow Publications and Media Pvt. Ltd.
Document Type: Report
Length: 1,359 words

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Byline: M. Vasundhara, Y. Karthik, K. Anjali, C. Chithra, Priyanka. Gupta, C. Roopa

Objective: To study the anthelmintic activity of Artabotrys hexapetalus (Linn.f) leaves. Materials and Methods: The extraction was made using the hydroalcohol with soxhlet extraction system. The hydroalcoholic extract of varying concentration was used for conducting anthelmintic activity (12.5, 25, 50 and 100 mg/ml). Eudrilus eugeniae (African adult earthworm) was used as the test organism. Result: The time of paralysis and death of the earthworms, the positive control (albendazole) was more effective and no effect was shown by the hydroalcoholic extract of varying concentrations. Conclusion: Hydroalcoholic extract of Artabotrys hexapetalus, didn't show any anthelmintic activity at the concentration of 12.5, 25, 50 and 100 mg/ml.

INTRODUCTION

Medicinal plants have served through ages, as a constant source of medicaments for the treatment of a variety of diseases. The history of herbal medicine is almost as old as human civilization. [sup][1] The World Health Organization (WHO) estimates that a staggering two billion people harbor parasitic worm infections. Parasitic worms also infect livestock and crops, affecting food production with a resultant economic impact. Despite this prevalence of parasitic infections, the research on the anthelmintic drug is sparse. According to the WHO, only a few drugs are used in the treatment of helminthes in humans. [sup][2] Anthelmintics are the drugs or agents that destroy or cause the expulsion of parasitic intestinal worms. Helminthiasis is a macro parasitic disease of humans and animals in which a part of the body is infested with parasitic worms such as pinworm, roundworm, or tapeworm. It can have immunomodulatory effects on the host, with implications for any co-infecting pathogens. [sup][3] An integrated approach is required for the effective control of helmintics, which includes strategic and tactical use of antihelmintics and careful management of grazing lands, including control of stocking rates and appropriate rotation strategies. [sup][4]

Artabotrys hexapetalus (Linn.f) belongs to the custard apple family Annonaceae, consisting of trees and shrubs with about 2300-2500 species and more than 130 genera. A. hexapetalus (Linn.f) commonly known as Manoranjini...

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Source Citation
Vasundhara, M., et al. "Absence of anthelmintic activity of hydroalcoholic leaf extracts of Artabotrys hexapetalus (Linn.f)." Journal of Pharmaceutical Negative Results, vol. 5, no. 1, 2014, p. 1. Accessed 24 Nov. 2020.
  

Gale Document Number: GALE|A377610582