Diabetes symptoms may cause by free radicals that cause memory problems and increases the risk of dementia. Diabetics are also at risk for nerve pain. Gallic acid has Anti-oxidant and anti- free radical properties. In this study Gallic acid administration on passive avoidance memory and pain in diabetic rats was investigated. Animal were divided into control group (healthy), diabetic with STZ (60mg/kg), 3 healthy and 3 diabetic groups who received Gallic acid(10, 50 and 100 mg / kg) for two weeks using Gavage method. Blood sugar levels were determined by taking blood from the tail. Findings show a significant memory decrease (delay in coming down the platform) in the diabetic group on all days except day of learning (P [less than or equal to] 0.01). Gallic acid dose of 50 shows significant increase in non-diabetic rats memory in the first day (P [less than or equal to] 0.01), third and seventh days (P [less than or equal to] 0.05) and dose of 10 in the first day (P [less than or equal to] 0.05). Also, there was a significant increase memory in the first day (P [less than or equal to] 0.01), third and seventh days (P [less than or equal to] 0.05) in diabetic groups received dose of 50 and 10 mg / kg Gallic acid. There was a significant decrease in tail pulling away reflex (delay in launching the tail) from the pain epicenter (P [less than or equal to] 0.01) in the diabetic group and the group receiving a Gallic acid dose of 50 a significant increase (P [less than or equal to] 0.01) in the delayed launch tail was observed. According to the findings Gallic acid having strong antioxidant effect may lead to Free radical's sweep and reduced complications of diabetes, including pain and possibly affect on certain regions of the neural pathways in the brain and improve memory in normal and diabetic rats. Keywords: diabetes, Gallic acid, pain memory, rats
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