Psychological Well-Being and the Human Conserved Transcriptional Response to Adversity

Citation metadata

Authors: Barbara L. Fredrickson, Karen M. Grewen, Sara B. Algoe, Ann M. Firestine, Jesusa M. G. Arevalo and Jeffrey Ma
Date: Mar. 26, 2015
From: PLoS ONE(Vol. 10, Issue 3)
Publisher: Public Library of Science
Document Type: Article
Length: 7,926 words

Main content

Abstract :

Research in human social genomics has identified a conserved transcriptional response to adversity (CTRA) characterized by up-regulated expression of pro-inflammatory genes and down-regulated expression of Type I interferon- and antibody-related genes. This report seeks to identify the specific aspects of positive psychological well-being that oppose such effects and predict reduced CTRA gene expression. In a new confirmation study of 122 healthy adults that replicated the approach of a previously reported discovery study, mixed effect linear model analyses identified a significant inverse association between expression of CTRA indicator genes and a summary measure of eudaimonic well-being from the Mental Health Continuum - Short Form. Analyses of a 2- representation of eudaimonia converged in finding correlated psychological and social subdomains of eudaimonic well-being to be the primary carriers of CTRA associations. Hedonic well-being showed no consistent CTRA association independent of eudaimonic well-being, and summary measures integrating hedonic and eudaimonic well-being showed less stable CTRA associations than did focal measures of eudaimonia (psychological and social well-being). Similar results emerged from analyses of pooled discovery and confirmation samples (n = 198). Similar results also emerged from analyses of a second new generalization study of 107 healthy adults that included the more detailed Ryff Scales of Psychological Well-being and found this more robust measure of eudaimonic well-being to also associate with reduced CTRA gene expression. Five of the 6 major sub-domains of psychological well-being predicted reduced CTRA gene expression when analyzed separately, and 3 remained distinctively prognostic in mutually adjusted analyses. All associations were independent of demographic characteristics, health-related confounders, and RNA indicators of leukocyte subset distribution. These results identify specific sub-dimensions of eudaimonic well-being as promising targets for future interventions to mitigate CTRA gene expression, and provide no support for any independent favorable contribution from hedonic well-being.

Source Citation

Source Citation
Fredrickson, Barbara L., et al. "Psychological Well-Being and the Human Conserved Transcriptional Response to Adversity." PLoS ONE, vol. 10, no. 3, 26 Mar. 2015. Accessed 19 Sept. 2021.

Gale Document Number: GALE|A421817992