The effect of green tea extract supplementation on liver enzymes in patients with nonalcoholic fatty liver disease

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Authors: Ali Pezeshki, Sara Safi, Awat Feizi, Gholamreza Askari and Fatemeh Karami
Date: January-December 2016
From: International Journal of Preventive Medicine(Vol. 7, Issue 1)
Publisher: Medknow Publications and Media Pvt. Ltd.
Document Type: Report
Length: 3,814 words

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Byline: Ali. Pezeshki, Sara. Safi, Awat. Feizi, Gholamreza. Askari, Fatemeh. Karami

Background: Green tea is one of the most popular beverages in the world. It is believed to have beneficial effects in the prevention and treatment of many diseases, one of which is nonalcoholic fatty liver disease (NAFLD). The present study investigated the effects of consumption of green tea in NAFLD patients. Methods: This study was a double-blind, placebo-controlled, randomized clinical trial. Ultrasonography was used to diagnose fatty liver in patients with alanine aminotransferase (ALT) >31 mg/dl and 41 mg/dl and aspartate aminotransferase (AST) >31 mg/dl and 47 g/dl in women and men, respectively and without other hepatic diseases. A total of 80 participants (20-50 years) with NAFLD were randomly allocated into two groups to receive either green tea extract (GTE) supplement (500 mg GTE tablet per day) or placebo for 90 days. At baseline and at the end of the intervention weight, serum ALT, AST, and alkaline phosphatase (ALP) were measured in fasting state, and dietary data were collected at baseline and end of the study. Results: Green tea group showed significant reductions in ALT and AST levels after 12 weeks period (P < 0.001). The placebo group showed a reduction in ALT and AST levels at the end of the study, but it was no significant. ALP levels showed significant reductions in both groups after 12 weeks period (P < 0.001). Conclusions: According to the findings of this study, GTE supplementation decrease liver enzymes in patients with NAFLD. It can be claimed that GTE prescribed can be considered as a treatment to improve serum levels of liver enzymes in NAFLD patients.


Nonalcoholic fatty liver disease (NAFLD) is a constellation of progressive liver disorders that are closely related to obesity, diabetes, and insulin resistance. NAFLD prevalence has increased with the change in eating habits, thus identifying an effective treatment for NAFLD is a significant public health objective. Lifestyle-related factors such as poor diet, obesity, excessive alcohol intake, diabetes, and hyperlipidemia have all been proposed to contribute to NAFLD. In addition to the development of a fatty liver, NAFLD patients may also exhibit inflammation, necrosis and fibrosis of the liver, which are known as nonalcoholic steatohepatitis (NASH). [sup][1] This disease may progress to cirrhosis of the liver and hepatocellular carcinoma. Lifestyle interventions such as improvement of eating habits or physical activity are commonly recommended for NAFLD and NASH, but no effective medical therapy for these diseases has been established, although many medications for the treatment of NAFLD is undergoing clinical trials in the Western countries.

Green tea ( Camellia sinensis ) is one of the most popular beverages in the World. It contains high levels of flavonoids, which have antioxidant properties. Catechin, one of the main flavonoids in green tea has recently attracted attention for its anti-tumor [sup][2] and anti-arteriosclerotic [sup][3] effects. Catechins account for ~20% of the flavonoids in green tea leaves. [sup][4] The major tea catechins include epicatechin, epicatechin gallate, epigallocatechin (EGC), and EGC gallate (EGCG). [sup][5]...

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Source Citation
Pezeshki, Ali, et al. "The effect of green tea extract supplementation on liver enzymes in patients with nonalcoholic fatty liver disease." International Journal of Preventive Medicine, vol. 7, no. 1, 2016, p. 28. Accessed 25 Oct. 2020.

Gale Document Number: GALE|A451938039