Cutaneous metastasis is considered as a hazardous condition depending on the mean survival around 9 months, which usually originates from cancers of the breast, lung, ovary, colon, and rarely from the cervix. The crucial prognostic factor of cutaneous metastasis depends on the period between the primary malignancy and cutaneous metastasis. We report two cases of the unusual presentation of squamous cell cancer of the cervix that developed vulvar and umbilical metastasis in the 5th month of primary treatment. Both of our patients survived for 11 months following the primary treatment. In addition, our first case is the earliest vulvar recurrence of cervical carcinoma in the English literature following appropriate medical and surgical management.
Keywords: Squamous cell cervical cancer, umbilical metastasis, vulvar metastasis
Deri metastazi ortalama sagkalim süresi 9 ay olan, genellikle meme, akciger, over, kolon ve nadiren de serviksten köken alan tehlikeli bir durumdur. Deri metastazi ve primer malignensi arasindaki zaman deri metastazinin olusumunda çok önemli bir prognostik faktördür. Primer tedavinin 5. ayinda gelisen skuamöz hücreli kanserin çok nadir görülen vulvar ve umbilikal metastaz olgularindan ikisini sunuyoruz. Olgularimizin ikisi de primer tedavi sonrasi 11 ay yasadilar. Sunmus oldugumuz ilk hasta uygun medikal ve cerrahi sonrasinda serviks kanserinin Ingilizce literatürdeki en erken vulvar rekürrensi olan olgudur.
Anahtar Kelimeler: Skuamöz hücreli serviks kanseri, umbilikal metastaz, vulvar metastaz
Cervical cancer recurrence depends on the cancer's clinical stage and may manifest as local or distant metastasis in different organs. Recurrence occurs most commonly in the pelvis, which includes the parametrium or lymph nodes, and in the vagina. Recurrence can rarely occur in the skin, ranging between 0.1-1.3%. In most cases, they manifest as an asymptomatic dermal/subcutaneous plaque, ulcer or nodule (1).
We report two unusual presentations of cervical squamous cell carcinoma with early vulvar and umbilical metastasis.
A woman aged 41 years was admitted to a state hospital with pelvic pain, urinary burning, and vaginal bleeding. The patient was referred to our hospital after a cervical biopsy revealed cervical squamous cell carcinoma. On our physical examination, we observed an exophytic necrotic mass measuring 8X9 cm confined to the cervix with no parametrial invasion. According to the International Federation of Gynecology and Obstetrics classification, we established the diagnosis as stage 1b-2 cervical cancer. We excised the mass through the vagina route and performed a type 3 radical hysterectomy (Wertheim) with pelvic-paraaortic lymph node dissection followed by radiotherapy. In the fifth month after surgical treatment, we observed a 2X3-cm ulcerated nodular vulvar lesion (Figure 1). The lesion in the vulva was excised following abdominopelvic computerized tomography (CT) imaging, which revealed no significant pathology. The biopsy specimen showed squamous cell carcinoma (Figure 2). A paclitaxel and carboplatin combined chemotherapy protocol was used. Following 2 cycles of chemotherapy, positron emission tomography-CT revealed diffuse metastases in the abdominopelvic...
This is a preview. Get the full text through your school or public library.