Incidental Finding of Papillary Thyroid Carcinoma in the Patients with Primary Hyperparathyroidism/Primer Hiperparatiroidi Hastalarinda insidental Papiller Tiroid Karsinomu Riski
From: The Eurasian Journal of Medicine(Vol. 47, Issue 3)
Document Type: Report
Length: 2,734 words
Objective: The relationship between primary hyperparathyroidism (pHPT) and papillary thyroid cancer (PTC) still remains unclear. We aimed to investigate the incidence of the co-existence of pHPT and PTC. Materials and Methods: Between 2010 and 2013, all patients with pHPT were retrospectively reviewed and those undergoing concomitant thyroid surgery were recorded. Of these, patients with a pathological result showing papillary or micro-papillary thyroid cancer were included into the study. A chart review of 228 patients who underwent surgery for pHPT revealed 86 (37.7%) patients with concurrent thyroid disease requiring surgical treatment. Results: Thyroid cancer was noted in six female patients (6.9%) undergoing thyroid resection, and 2.6% of all patients with pHPT. Four patients underwent total thyroidectomy while lobectomy was applied in the remaining two. None of the cases with lobectomy required a completion thyroidectomy. Conclusion: We demonstrated the concurrence of PTC and pHPT at a rate of 2.6% which appeared as a coincidental pathology; however, thyroid disorders, seen in one of three patients with pHPT, were not uncommon. Further research is still needed to develop a reliable explanation for relationship between pHPT and non-medullary thyroid cancer. Keywords: Primary hyperparathyroidism, thyroid disorders, surgical treatment, papillary thyroid cancer Amac: Her ne kadar primer hiperparatiroidi (pHPT) ile meduller tiroid kanser iliskisi bilinse de papiller tiroid kanseri ile iliskisi halen net degildir. Biz bu calismada pHPT tanisi nedeniyle opere ettigimiz hastalardaki papiller tiroid kanser sikligini incelemeyi amacladik. Gerec ve Yontem: Primer HPT tanisi ile 2010 ve 2013 yillari arasinda es zamanli tiroid cerrahisi uygulanan hastalar retrospektif olarak incelendi. Bu hastalardan patoloji sonucunda papiller veya mikropapiller trioid kanseri tanisi alan hastalar calismaya dahil edildi. Calisma surecinde pHPT tanisi ile cerrahi tedavi uygulanan 228 hastadan 86'sinda (%37,7) ek tiroid cerrahisi uygulandigi saptandi. Bulgular: Ek tiroid cerrahisi uygulanan 6 kadin hastada (%6,9)-pHPT hastalarinin %2,6'si tiroid kanseri saptandi. Dort hastada total tiroidektomi papiller diger 2 hastada lobektomi yapildi. Hastalarin hicbirinde tamamlayici tiroidektomiye ihtiyac duyulmadi. Sonuc: Primer HPT hastalarinda %30 oraninda tiroid patolojisi izlenmesine ragmen %2,6 gibi dusuk bir orandaki tiroid kanser birlikteligi tesadufi olarak iliskilendirilebilir. Fakat meduller olmayan tiroid kanseri ile pHPT arasindaki baga daha guvenilir bir aciklama getirebilmek icin ileri calismalar gerekmektedir. Anahtar Kelimeler: Primer hiperparatiroidi, tiroid bezi hastaliklari, cerrahi tedavi, papiller tiroid kanseri
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