Hyperforin content of St John's wort products and drug interactions

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Author: Jodie Tester
Date: June 2018
From: Australian Journal of Herbal and Naturopathic Medicine(Vol. 30, Issue 2)
Publisher: National Herbalists Association of Australia
Document Type: Article
Length: 498 words

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Hyperforin content of St John's wort products and drug interactions

Chrubasik-Hausman S, Vlachojannis J, McLachlan A. Understanding drug interactions with St John's wort (Hypericum perforatum L.): impact of hyperforin content. J Pharm Pharmacol 2018. Available online: doi:10/1111/jphp.12858

St John's wort (Hypericum perforatum) (SJW) is one of the most commonly used herbal medicines worldwide. Co-administration of SJW preparations is known to be associated with significant interactions with a range of medicines. SJW acts as an inducer of drug-metabolising enzymes and transporters, leading to reduced systemic exposure and risk of therapeutic failure; however, the extent of interactions are highly variable with interactions difficult to predict based on SJW dose alone.

Previous research has suggested that the interactions of SJW are likely to be related to the...

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Source Citation
Tester, Jodie. "Hyperforin content of St John's wort products and drug interactions." Australian Journal of Herbal and Naturopathic Medicine, vol. 30, no. 2, 2018, p. 89+. Accessed 10 Apr. 2021.
  

Gale Document Number: GALE|A582622171