Hyperforin content of St John's wort products and drug interactions
Chrubasik-Hausman S, Vlachojannis J, McLachlan A. Understanding drug interactions with St John's wort (Hypericum perforatum L.): impact of hyperforin content. J Pharm Pharmacol 2018. Available online: doi:10/1111/jphp.12858
St John's wort (Hypericum perforatum) (SJW) is one of the most commonly used herbal medicines worldwide. Co-administration of SJW preparations is known to be associated with significant interactions with a range of medicines. SJW acts as an inducer of drug-metabolising enzymes and transporters, leading to reduced systemic exposure and risk of therapeutic failure; however, the extent of interactions are highly variable with interactions difficult to predict based on SJW dose alone.
Previous research has suggested that the interactions of SJW are likely to be related to the...
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