Design, Synthesis, and Spectroscopic Study of 7-Azaindolyl Hydrazones with Anti-Breast Cancer Activity

Citation metadata

Authors: Sakharam B. Dongare, Babasaheb. P. Bandgar, Pravin S. Bhale, Sadanand N. Shringare and Hemant V. Chavan
Date: Jan. 2019
From: Croatica Chemica Acta(Vol. 92, Issue 1)
Publisher: Croatica Chemica Acta
Document Type: Article
Length: 5,596 words

Main content

Abstract :

A series of 7-azaindolyl hydrazones were prepared by reacting of hydrazides of 7-azaindole-3-acetic acids with aromatic aldehydes and N-substituted indolyl-3-carboxyaldehydes. Structure of all the synthesized compounds were satisfactorily correlated by IR, [.sup.1]H NMR, [.sup.13]C NMR and mass spectroscopic evidences. The synthesized compounds were evaluated for their possible anticancer potential against MCF-7 induced breast carcinoma. It is worth mentioning that most of the compounds were considerably active against MCF-7 cell line with [GI.sub.50] values ranging from 22.3-81.0 [micro]M. The hydrazones of N-1-substituted indole-3-carboxyaldehydes 9f, 9g, 9h, 9c, and 9j were active against MCF-7 cell line with [GI.sub.50] values less than 40 [micro]M ([GI.sub.50] = 22.3 and 24.9, 29.6, 30.2 and 37.8 [micro]M respectively) with moderate TGI values (TGI = 56.6, 59.5, 65.5, 70.7 and 94.6 [micro]M respectively). The active compounds were also screened against the normal Vero monkey cell line, which showed moderate selectivity against inhibition of cancer cells. Keywords: 7-azaindole, hydrazone, breast carcinoma.

Source Citation

Source Citation
Dongare, Sakharam B., et al. "Design, Synthesis, and Spectroscopic Study of 7-Azaindolyl Hydrazones with Anti-Breast Cancer Activity." Croatica Chemica Acta, vol. 92, no. 1, 2019, p. 1+. Accessed 10 Apr. 2021.
  

Gale Document Number: GALE|A596849555