A series of 7-azaindolyl hydrazones were prepared by reacting of hydrazides of 7-azaindole-3-acetic acids with aromatic aldehydes and N-substituted indolyl-3-carboxyaldehydes. Structure of all the synthesized compounds were satisfactorily correlated by IR, [.sup.1]H NMR, [.sup.13]C NMR and mass spectroscopic evidences. The synthesized compounds were evaluated for their possible anticancer potential against MCF-7 induced breast carcinoma. It is worth mentioning that most of the compounds were considerably active against MCF-7 cell line with [GI.sub.50] values ranging from 22.3-81.0 [micro]M. The hydrazones of N-1-substituted indole-3-carboxyaldehydes 9f, 9g, 9h, 9c, and 9j were active against MCF-7 cell line with [GI.sub.50] values less than 40 [micro]M ([GI.sub.50] = 22.3 and 24.9, 29.6, 30.2 and 37.8 [micro]M respectively) with moderate TGI values (TGI = 56.6, 59.5, 65.5, 70.7 and 94.6 [micro]M respectively). The active compounds were also screened against the normal Vero monkey cell line, which showed moderate selectivity against inhibition of cancer cells. Keywords: 7-azaindole, hydrazone, breast carcinoma.
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