Background: Plant flavonoid has emerged as the popular therapeutic nature drugs effective against a wide range of diseases including diabetes. Antidiabetic properties of extracted A. excelsa leaves have been proven in animal models. Therefore, the intention of this study was to explore other roles of A. excelsa and quercetin in preventing and managing diabetes complications. The purpose of this study was to evaluate the effect of A. excelsa on histology and insulin secretion changes in pancreas of diabetic rats induced with streptozotocin (STZ, 60 mg/kg b.wt). Methods: Five groups with six male Sprague-Dawley rats in each group were treated as follows: Group I Normal control (NC) saline; Group II Diabetic control (DC) saline; Group III Diabetic treated with metformin (DMET) (1000 mg/kg b.wt); Group IV Diabetic treated with A. excelsa (DAE) (250 mg/kg b.wt) and Group V Diabetic treated with quercetin (DQ) (40 mg/kg b.wt). All treatments were given once daily for 8 weeks. Subsequently, insulin resistance was assessed by using homeostasis assessment model of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI) and the insulin/triglyceride-derived McAuley index. The histological changes in the pancreas were observed on hematoxylin-eosin (H&E) stained tissue. Results: Both A. excelsa and quercetin were found to improve insulin level and promote [beta]-cells replenishment. Therefore, ethanolic extract of A. excelsa depicted a potential to ameliorate pancreas in diabetic rats better than the common drugs metformin. Conclusion: These results emphasize that both A. excelsa and quercetin could be the potential agent to attenuate pancreatic oxidative damage and advocate their therapeutic potential for treating DM. KEYWORDS: A. excelsa, Quercetin, Oxidative stress, Pancreas, HOMA-IR, QUICKI, McAuley index, Hematoxylin-eosin (H&E)
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