Pouwels MJ, Tack CJ, Hermus AR, Lutterman JA: Treatment with intravenous insulin followed by continuous subcutaneous insulin infusion improves glycaemic control in severely resistant type 2 diabetic patients. Diabet Med 20:76-79, 2003
Findings. This study tested the hypothesis that subcutaneous insulin infusion (CSII) would ameliorate the deleterious effects of hyperglycemia on insulin sensitivity ("glucose toxicity") and result in sustained, improved metabolic control. This was a prospective observational study in eight type 2 diabetic patients with insulin resistance (defined as an insulin dose 1.92 [+ or -] 0.66 units * [kg.sup.-1] * [day.sup.-1] [mean [+ or -] SD]) and poor metabolic control ([HbA.sub.1c] 12.0 [+ or -] 1.7%). They were treated...