Isoflavones and cognition

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Author: Tori Hudson
Date: Oct. 2003
Publisher: The Townsend Letter Group
Document Type: Article
Length: 675 words

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Healthy postmenopausal women, aged 55 to 74 who had normal cognition, participated in a 6 month, double-blind, randomized, placebo-controlled clinical trial, called the Soy and Postmenopausal Health in Aging Study (SOPHIA). They were not on estrogen replacement therapy and were at least 2 years postmenopausal. Women were randomized into two groups, a placebo group and one who took 110 mg soy isoflavones in pills. Cognitive function tests were administered at baseline and follow-up using a standard questionnaire, the Beck Depression Inventory, the Mini-mental Status Examination (a screening test for dementia), Trails A and Trails B from the Halstead-Reitan Neuropsychological Test Battery (an instrument used to demonstrate differences among older individuals in cognitive function), Category Fluency (a test of verbal memory), and a memory and recall test from the Wechsler memory scale.

In this clinical trial, isoflavone supplementation significantly improved performance on category fluency and showed a nonsignificant pattern of improvement on other tests of verbal memory, visuomotor tracking and attention. Isoflavone supplementation in the older women in the...

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Gale Document Number: GALE|A109946573