Side effects of conventional nonsteroidal anti-inflammatory drugs and celecoxib: more similarities than differences

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Date: Feb. 2004
From: Southern Medical Journal(Vol. 97, Issue 2)
Publisher: Southern Medical Association
Document Type: Letter to the editor
Length: 435 words

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To the Editor: Cyclooxygenase-2 (COX-2) inhibitors are a new class of nonsteroidal anti-inflammatory drugs (NSAIDs) with a reported benefit of less gastric and duodenal ulceration. Nevertheless, it has been shown that COX-2 inhibitors are not completely "ulcer-proof." (1) Whereas the gastrointestinal side effects of NSAIDs are a matter of concern and interest, the cardiovascular and renal side effects of these drugs are less well appreciated. NSAIDs, including both conventional and COX-2 inhibitors, inhibit the synthesis of prostaglandins. Pathophysiologically, NSAIDs may increase blood pressure by renal and extrarenal mechanisms such as the reninangiotensin pathway, alterations in sodium and water retention, inhibition of vasodilating prostaglandins, and production of various vasoconstricting...

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Gale Document Number: GALE|A114134744