Hypoglycaemic effects of fermented mycelium of Paecilomyces farinosus (G30801) on high-fat fed rats with streptozotocin-induced diabetes

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From: Indian Journal of Medical Research(Vol. 131, Issue 5)
Publisher: Medknow Publications and Media Pvt. Ltd.
Document Type: Report
Length: 3,070 words
Lexile Measure: 1420L

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Abstract :

Background & objectives: Paceilomyces farinosus is an entomogenous fungus with a powerful insecticidal activity against the larvae of Lipidoptera, Coleoptera and Hymenoptera. However, the hypoglycaemic activity of P. farinosus extract has not been studied. This study was undertaken to investigate the hypoglycaemic and anti-diabetic effects of P. farinosus (G30801) in rats with streptozotocin (STZ)-induced diabetes given a high-fat and compared with normal rats. Methods: Rats fed with high fat diet for 2 months and injected with (30 or 50 mg STZ/kg bw) showed raised level of plasma triglyceride (TG), cholesterol, D-glucose concentration and glycosylated haemoglobin (HbA1C) %. The STZ-induced type 1 (T1DM) and type 2 diabetes (T2DM) in rats was further confirmed using glucose tolerance test and insulin-glucose tolerance test. P. farinosus (G30801) was fermented in different media [soybean (S), black bean (B), and rice (R)] and their extracts were tested for hypoglycaemic effect using T1DM and T2DM rats. Results: STZ (30 and 50 mg/kg bw) could successfully induce T2DM and T1DM in rats, respectively. No change in blood glucose levels were noted in P. farinosus (R medium) treated normal rats (P Interpretation & conclusions: Our findings showed hypoglycaemic effect of fermented P. farinosus (G30801) in experimental diabetes rat model fed with high fat diet. Key words Diabetes--high-fat--hypoglycaemia--insulin--Paecilomyces farinosus--streptozotocin

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Gale Document Number: GALE|A237135614