Aim of the work- Non-steroidal anti-inflammatory drugs is the most common treatment for inflammatory diseases due to its effectiveness and its ability to relieve pain and fever. Arcoxia has possibility to cancer prevention and treatment of migraine and it used to treat osteoarthritis disease. Parsley has ability to remove toxins from the body and is used the therapy of diabetes, treat mouth ulcers, boils, wounds and cracks the skin by placing compresses on wounds or abscesses. It is useful in curing diseases and oversized spleen helps the descent of gravel and sand kidney, so the present study aims to investigate the protective effect of parsley oil t on the fetal lung kidney of pregnant rats. Material and methods--Forty pregnant albino rats were used and categorized after mating into four groups. Each group was consisted of 10 females. The animals were divided into the following groups: group 1: control group, group 2: pregnant rats treated with Arcoxia Drug (2mg/rat) by intraperitoneal injection for 7 days from the 8th day to the 14th day of pregnancy, group 3: pregnant rats treated with parsley oil (0.5mg/rat) by intraperitoneal injection for 7 days from the 8th day to the 14th day of pregnancy, group 4:pregnant rats treated with Arcoxia Drug (2mg/rat) then parsley oil (0.5mg/rat) by intraperitoneal injection for 7 consecutive days from the 8th day to the 14th day of pregnancy.Kidney samples of fetuses were taken for the histological and histopatholigical studies for ectopic and electronic microscope. Results- Histological and histopathological observations of fetal kidney tissue showed that the parsley oil succeeded to minimize the drastic changes which were observed in the fetal kidney of Arcoxia drug pregnant rats. Conclusion- It is recommended that the use of the parsley oil has the ability to minimize the adverse effects in the fetal kidney tissue of pregnant rats treated with Arcoxia drug. KEYWORDS: Pregnant rats, Arcoxia drug, parsley oil, fetus, kidney.