P27. KETOGENIC DIET BUT NOT KETONE BODIES INCREASES SOCIAL ACTIVITY IN YOUNG MALE RATS

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From: Acta Neurobiologiae Experimentalis(Vol. 77, Issue 2)
Publisher: Exeley Inc.
Document Type: Report
Length: 492 words
Lexile Measure: 1380L

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Highfat ketogenic diet (HFKD) is increasingly considered as an alternative or add-on therapy in Autism spectrum disorders (ASD). Given the beneficial effect of HFKD on epilepsy mitochondrial function, carbohydrate metabolism and inflammation, the treatment with HFKD has potential to reduce some of the ASD-associated symptoms including abnormal social interactions. It is not known whether HFKD influences social interactions by reducing the pathological processes underlying ASD or through some independent mechanism. The aim of our study was to evaluate the influence of HFKD on social activity in healthy young male rats.

Four weeks old male Long Evans rats were treated with HFKD or ketone bodies for following 4 weeks. Subsequently behavioral tests were performed in order to evaluate social interactions, locomotor activity working memory...

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Gale Document Number: GALE|A543992092