Pittler MH, Ernst E. Horse-chestnut seed extract for chronic venous insufficiency. Arch Dermatol 1998; 134:1356-60.
Clinical question Does horse-chestnut seed extract (HCSE) reduce symptoms of chronic venous insufficiency?
Background Chronic venous insufficiency (CVI) is a common medical problem that occurs in 10% to 15% of men and 20% to 25% of women. At least two thirds of leg ulcers have evidence of venous disease in the affected limb. The current standard medical therapy is the use of compression stockings, but patient compliance is often poor. HCSE is an oral herbal remedy commonly used for the treatment of CVI. The active component of HCSE is escin, which is believed to prevent leukocyte activation, one mechanism in the development of CVI.
Population studied This is a systematic review of 13 studies with 1083 total patients.
Study design and validity The reviewers systematically and comprehensively searched...