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From:Nature (Vol. 465, Issue 7295) Peer-ReviewedScience 328, 753-756 (2010) Why do learning and memory deteriorate with age? Scientists have speculated that changes in gene expression are involved, but little is known about the mechanism. Andre Fischer at the...
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From:Diabetes (Vol. 62, Issue 3) Peer-ReviewedHistone deacetylase (HDAC) has emerged as a new molecular target in the control of obesity and type 2 diabetes. HDAC is an enzyme with well-known functions in the regulation of chromatin structure and gene transcription...
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From:Biochemistry and Cell Biology (Vol. 97, Issue 1) Peer-ReviewedLysine acetylation is a critical post-translation modification that can impact a protein's localization, stability, and function. Originally thought to only occur on histones, we now know thousands of nonhistone...
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From:eLife (Vol. 4) Peer-ReviewedThe re-assembly of chromatin following DNA replication is a critical event in the maintenance of genome integrity. Histone H3 acetylation at K56 and phosphorylation at T45 are two important chromatin modifications that...
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From:Biotechnology for Biofuels (Vol. 11, Issue 1) Peer-ReviewedBackground Softwood is a promising feedstock for lignocellulosic biorefineries, but as it contains galactoglucomannan efficient mannan-degrading enzymes are required to unlock its full potential. Results...
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From:BMC Research Notes (Vol. 11, Issue 1) Peer-Reviewed
Investigating the functionality of a ribosome-binding mutant of NAA15 using Saccharomyces cerevisiae
Objective N-terminal acetylation is a common protein modification that occurs preferentially co-translationally as the substrate N-terminus is emerging from the ribosome. The major N-terminal acetyltransferase... -
From:Nature Medicine (Vol. 15, Issue 12) Peer-ReviewedThe mammalian protein sirtuin-1 (SIRT1), the target of the age-defying molecule resveratrol, seems to operate in part through a protein known for its role in regulating lipid and glucose metabolism, the farnesoid X...
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From:Current Topics in Nutraceutical Research (Vol. 15, Issue 1) Peer-ReviewedAllium tuberosum is widely cultivated in Asian countries and has been reported to be effective for the prevention of certain diseases, including atherosclerosis. The current study was designed to evaluate the inhibitory...
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From:PLoS ONE (Vol. 13, Issue 7) Peer-Reviewed
pTSara-NatB, an improved N-terminal acetylation system for recombinant protein expression in E. coli
N-terminal acetylation is one of the most common co- and post-translational modifications of the eukaryotic proteome and regulates numerous aspects of cellular physiology, such as protein folding, localization and... -
From:Journal of Biomedicine and BiotechnologyPeer-ReviewedMyelodysplastic syndrome (MDS) represents a heterogeneous group of diseases with clonal proliferation, bone marrow failure and increasing risk of transformation into an acute myeloid leukaemia. Structured guidelines are...
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From:Journal of Biomedicine and BiotechnologyPeer-ReviewedReversible posttranslational modification of internal lysines in many cellular or viral proteins is now emerging as part of critical signalling processes controlling a variety of cellular functions beyond chromatin and...
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From:Neural Regeneration Research (Vol. 15, Issue 12) Peer-ReviewedByline: Xin. Wang, Zhao-Xiang. Meng, Ying-Zhu. Chen, Yu-Ping. Li, Hong-Yu. Zhou, Man. Yang, Ting-Ting. Zhao, Yu-Lai. Gong, Yi. Wu, Tao. Liu The mechanisms of age-associated memory impairment may be associated with...
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From:PLoS ONE (Vol. 11, Issue 4) Peer-ReviewedDysfunction of histone acetylation inhibits topoisomerase II[alpha] (Topo II[alpha]), which is implicated in benzene-induced hematotoxicity in patients with chronic benzene exposure. Whether histone deacetylase (HDAC)...
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From:PLoS ONE (Vol. 10, Issue 12) Peer-ReviewedPoly(ADP-ribosyl)ation (PARylation) is a posttranslational protein modification catalyzed by members of the poly(ADP-ribose) polymerase (PARP) enzyme family. PARylation regulates a wide variety of biological processes...
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From:Nature Medicine (Vol. 16, Issue 11) Peer-ReviewedThe microtubule-binding protein tau accumullates in many neurodegenerative conditions, leading to neuronal dysfunction. Sang-Won Min et al. now report that acetylation of tau enhances its stability by reducing its...
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From:Alcohol Research: Current Reviews (Vol. 35, Issue 1) Peer-ReviewedChronic alcohol exposure causes widespread changes in brain gene expression in humans and animal models. Many of these contribute to cellular adaptations that ultimately lead to behavioral tolerance and alcohol...
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From:PLoS ONE (Vol. 9, Issue 4) Peer-ReviewedPost-translational protein modifications such as acetylation have significant regulatory roles in metabolic processes, but their relationship to both variation in gene expression and DNA sequence is unclear. We address...
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From:Journal of Biomedicine and BiotechnologyPeer-ReviewedAcetylation of lysines is a prominent form of modification in mammalian proteins. Deacetylation of proteins is catalyzed by histone deacetylases, traditionally named after their role in histone deacetylation,...
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From:Pakistan Journal of Life and Social Sciences (Vol. 11, Issue 2)Byline: Sadaf Saleem Tahira Iqbal Amer Jamil and Faqir Hussain Khan ABSTRACTN-Acetyletransferase-1 (NAT1) is the phase II metabolizing enzyme renders for the detoxification of many drugs and arylamines present in...
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From:Proceedings of the Indiana Academy of Science (Vol. 118, Issue 2) Peer-Reviewed
Acetylation labeling mass spectrometry: a method for studying protein conformations and interactions
ABSTRACT. To support the ongoing effort to characterize and understand the specificity of phytopathogens for various crops, it has been necessary to develop a quick and robust method for observing the interactions of...