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    Academic Journals

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• Structure, function, and assembly of membrane proteins

  Author:Efraim RackerFrom:Science (Vol. 235) Peer-Reviewed

  Feb. 27, 19873,210 words Article I have recently had the opportunity to canvass the work and views of a group of scientists who attended a Nobel symposium on "Membrane proteins: Structure, function and assembly," held in Kalskoga, Sweden, in beautiful...

• A monoclonal antibody to the alpha subunit of Gk blocks muscarinic activation of atrial K+ channels

  Authors:Atsuko Yatani, Heidi Hamm, Juan Codina, Maria R. Mazzoni, Lutz Birnbaumer, and Arthur M. BrownFrom:Science (Vol. 241, Issue 4867) Peer-Reviewed

  Aug. 12, 19881,814 words Article A Monoclonal Antibody to the & Subunit of G.sub.k Blocks Muscarinic Activation of Artial K.sub.+ Channels COUPLING BETWEEN THE ATRIAL muscarinic acetylcholine receptor and the potassium channel current...

• More Power to Your Arm

  Author:SMHFrom:Science (Vol. 293, Issue 5528) Peer-Reviewed

  July 13, 2001156 words Brief article At the neuromuscular junction, nerves and muscle interact and clusters of muscle acetylcholine receptors(AChRs) form in association with neuronal agrin. Using purified recombinant chick agrin derived either from muscle...

• Novel mutation in the muscle acetylcholine receptor a-subunit underlies a fast channel congenital myasthenic syndrome. (ABN Abstracts)

  Authors:R. Webster, A. Vincent, J. Newsom-Davis, and D. BeesonFrom:Journal of Neurology, Neurosurgery and Psychiatry (Vol. 73, Issue 2) Peer-Reviewed

  Aug. 2002214 words Abstract, Brief arti... Background: Congenital myasthenic syndromes (CMS) are frequently caused by mutations in the muscle acetylcholine receptor (AChR). The mutations may result in reduced receptor number and/or kinetic abnormalities that...

• Nonintubated video-assisted thoracoscopic surgery using regional anesthesia and targeted sedation in a myasthenia gravis patient

  Authors:Hou-Chuan Lai, Tsai-Wang Huang, Hung Chang, Nan-Kai Hung, Chen-Hwan Cherng, and Zhi-Fu WuFrom:Journal of Medical Sciences (Vol. 36, Issue 4) Peer-Reviewed

  July-August 20161,649 words Case study 1800LByline: Hou-Chuan. Lai, Tsai-Wang. Huang, Hung. Chang, Nan-Kai. Hung, Chen-Hwan. Cherng, Zhi-Fu. Wu Myasthenia gravis (MG) is a disease affecting the acetylcholine receptor in the neuromuscular junction. Symptoms of...

• Maintenance of acetylcholine receptor number by neuregulins at the neuromuscular junction in vivo

  Authors:Alfred W. Sandrock, Stuert E. Dryer, Kenneth M. Rosen, Shai N. Gozani, Rainer Kramer, Lars E. Theill, et al.From:Science (Vol. 276, Issue 5312) Peer-Reviewed

  Apr. 25, 19974,952 words Article ARIA (for acetylcholine receptor-inducing activity), a protein purified on the basis of its ability to stimulate acetylcholine receptor (AChR) synthesis in cultured myotubes, is a member of the neuregulin family and is...

• Nicotinic Receptor Alpha7 Expression Identifies a Novel Hematopoietic Progenitor Lineage

  Authors:Lorise C. Gahring, Elena Y. Enioutina, Elizabeth J. Myers, Gerald J. Spangrude, Olga V. Efimova, Todd W. Kelley, et al.From:PLoS ONE (Vol. 8, Issue 3) Peer-Reviewed

  Mar. 1, 20139,743 words Report 1520LAuthor(s): Lorise C. Gahring 1 , 2 , 3 , * , Elena Y. Enioutina 2 , 3 , Elizabeth J. Myers 2 , Gerald J. Spangrude 3 , 4 , Olga V. Efimova 3 , 5 , Todd W. Kelley 3 , 5 , Petr Tvrdik 6 , Mario R. Capecchi 6 , Scott W....

• Identification, expression and functional characterization of M.sub.4L, a muscarinic acetylcholine M.sub.4 receptor splice variant

  Authors:Douglas A. Schober, Carrie H. Croy, Cara L. Ruble, Ran Tao, and Christian C. FelderFrom:PLoS ONE (Vol. 12, Issue 12) Peer-Reviewed

  Dec. 6, 20175,584 words Report 1500LRodent genomic alignment sequences support a 2-exon model for muscarinic M4 receptor. Using this model a novel N-terminal extension was discovered in the human muscarinic acetylcholine M.sub.4 receptor. An open reading...

• Neuronal Nicotinic Acetylcholine Receptor Modulators Reduce Sugar Intake

  Authors:Masroor Shariff, Maryka Quik, Joan Holgate, Michael Morgan, Omkar L. Patkar, Vincent Tam, et al.From:PLoS ONE (Vol. 11, Issue 3) Peer-Reviewed

  Mar. 30, 20167,245 words Report 1500LExcess sugar consumption has been shown to contribute directly to weight gain, thus contributing to the growing worldwide obesity epidemic. Interestingly, increased sugar consumption has been shown to repeatedly elevate...

• Evidence that the M2 membrane-spanning region lines the ion channel pore of the nicotinic receptor

  Authors:Reid J. Leonard, Cesar G. Labarca, Pierre Charnet, Norman Davidson, and Henry A. LesterFrom:Science (Vol. 242, Issue 4885) Peer-Reviewed

  Dec. 16, 19882,128 words Article Evidence That the M2 Membrane-Spanning Region Lines the Ion Channel Pore of the Nicotinic Receptor THE NICOTINIC ACETYLCHOLINE REceptor (AChR) contains both binding sites for agonists and an aqueous cation-selective...

• Acetylcholine receptor channel structure probed in cysteine-substitution mutants

  Authors:Myles H. Akabas, David A. Stauffer, Ming Xu, and Arthur KarlinFrom:Science (Vol. 258, Issue 5080) Peer-Reviewed

  Oct. 9, 19923,136 words Article In order to understand the structural bases of ion conduction, ion selectivity, and gating in the nicotinic acetylcholine receptor, mutagenesis and covalent modification were combined to identify the amino acid residues...

• Rapid and Reversible Effects of Activity on Acetylcholine Receptor Density at the Neuromuscular Junction in Vivo

  Authors:Mohammed Akaaboune, Susan M. Culican, Stephen G. Turney, and Jeff W. LichtmanFrom:Science (Vol. 286, Issue 5439) Peer-Reviewed

  Oct. 15, 19993,764 words Article Quantitative fluorescence imaging was used to study the regulation of acetylcholine receptor (AChR) number and density at neuromuscular junctions in living adult mice. At fully functional synapses, AChRs have a...

• Association of Common Polymorphisms in the Nicotinic Acetylcholine Receptor Alpha4 Subunit Gene with an Electrophysiological Endophenotype in a Large Population-Based Sample

  Authors:A. Mobascher, A. Diaz-Lacava, M. Wagner, J. Gallinat, T. F. Wienker, D. Drichel, et al.From:PLoS ONE (Vol. 11, Issue 4) Peer-Reviewed

  Apr. 7, 20166,040 words Report 1460LVariation in genes coding for nicotinic acetylcholine receptor (nAChR) subunits affect cognitive processes and may contribute to the genetic architecture of neuropsychiatric disorders. Single nucleotide polymorphisms...

• Effects of Alpha-bungarotoxin on Development of the Sea Urchin Arbacia punctulata

  Authors:Blase Billack, Jeffrey D. Laskin, Michael A. Gallo, and Diane E. HeckFrom:The Biological Bulletin (Vol. 197, Issue 2) Peer-Reviewed

  Oct. 1999579 words Brief article Recent evidence suggests that the expression of acetylcholine receptors is important in regulating growth and development (1). Normally, as sea urchins develop and progress through the pluteus stage, the postoral arms...

• Inhibitory muscarinic acetylcholine receptors enhance aversive olfactory learning in adult Drosophila

  Authors:Noa Bielopolski, Hoger Amin, Anthi A Apostolopoulou, Eyal Rozenfeld, Hadas Lerner, Wolf Huetteroth, et al.From:eLife (Vol. 8) Peer-Reviewed

  June 19, 201920,152 words Report 1450LOlfactory associative learning in Drosophila is mediated by synaptic plasticity between the Kenyon cells of the mushroom body and their output neurons. Both Kenyon cells and their inputs from projection neurons are...

• Component of nicotine-induced intracellular calcium elevation mediated through [alpha]3- and [alpha]5-containing nicotinic acetylcholine receptors are regulated by cyclic AMP in SH-SY 5Y cells.

  Authors:Tamayo Takahashi, Takayuki Yoshida, Kana Harada, Tatsuhiko Miyagi, Kouichi Hashimoto, Izumi Hide, et al.From:PLoS ONE (Vol. 15, Issue 11) Peer-Reviewed

  Nov. 30, 20207,216 words Report 1390LThe pathway from the medial habenular nucleus to the interpeduncular nucleus, in which nicotinic acetylcholine receptor (nAChR) including the [alpha]3 and [alpha]5 subunits ([alpha]3 * and [alpha]5 * nAChRs) are...

• Alpha7 acetylcholine receptor autoantibodies are rare in sera of patients diagnosed with schizophrenia or bipolar disorder

  Authors:Carolin Hoffmann, Jo Stevens, Shenghua Zong, Daan van Kruining, Abhishek Saxena, Cem Ismail Kucukali, et al.From:PLoS ONE (Vol. 13, Issue 12) Peer-Reviewed

  Dec. 6, 20185,804 words Report 1490LThe [alpha]7 acetylcholine receptor (AChR) has been linked with the onset of psychotic symptoms and we hypothesized therefore that it might also be an autoimmune target. Here, we describe a new radioimmunoassay (RIA)...

• Resolution of complex fluorescence spectra of lipids and nicotinic acetylcholine receptor by multivariate analysis reveals protein-mediated effects on the receptor's immediate lipid microenvironment

  Authors:Jorge J. Wenz and Francisco J. BarrantesFrom:PMC Biophysics (Vol. 1, Issue 6) Peer-Reviewed

  Dec. 18, 20087,097 words Article Analysis of fluorescent spectra from complex biological systems containing various fluorescent probes with overlapping emission bands is a challenging task. Valuable information can be extracted from the full spectra,...

• Multiple-dose pharmacokinetics of the selective nicotinic receptor partial agonist, varenicline, in healthy smokers

  Authors:Helene M. Faessel, Megan A. Gibbs, David J. Clark, Kevin Rohrbacher, Marilyn Stolar, and Aaron H. BursteinFrom:Journal of Clinical Pharmacology (Vol. 46, Issue 12) Peer-Reviewed

  Dec. 20065,154 words Clinical report 1810LVarenicline is a novel and selective [alpha]4[beta]2 nicotinic acetylcholine receptor partial agonist developed for smoking cessation. The primary objectives of this double-blind, placebo-controlled, dose-escalation...

• Nicotine improves the functional activity of late endothelial progenitor cells via nicotinic acetylcholine receptors

  Authors:Min Yu, Qian Liu, Jing Sun, Kaihong Yi, Libiao Wu, and Xuerui TanFrom:Biochemistry and Cell Biology (Vol. 89, Issue 4) Peer-Reviewed

  Aug. 20113,544 words Report 1360LThe aim of this study is to investigate whether nicotinic acetylcholine receptors (nAChRs) are involved in the modulation of functional activity of late endothelial progenitor cells (EPCs) induced by nicotine. Total...