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From:Diabetes (Vol. 62, Issue 2) Peer-ReviewedReceptor for advanced glycation end products (RAGE) has been shown to be involved in adiposity as well as atherosclerosis even in nondiabetic conditions. In this study, we examined mechanisms underlying how RAGE...
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From:Pediatrics (Vol. 102, Issue 2) Peer-ReviewedA teenage boy developed an abnormal accumulation of abdominal fat following more than two years of abdominal subcutaneous injections of growth hormone to treat short stature. His parents were instructed to inject the...
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From:Diabetes (Vol. 59, Issue 10) Peer-ReviewedOBJECTIVE--Growth of white adipose tissue takes place in normal development and in obesity. A pool of adipose progenitors is responsible for the formation of new adipocytes and for the potential of this tissue to expand...
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From:Nature (Vol. 488, Issue 7411) Peer-ReviewedIn humans as in other mammals, fat is stored in white fat cells, whereas brown fat cells burn fat to generate heat. However, it seems that not everything is white or brown. Writing in Cell, Wu et al. (1) present...
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From:Diabetes (Vol. 50, Issue 6) Peer-ReviewedProtease inhibitors used in the treatment of HIV infection have been causally associated with lipodystrophy and insulin resistance and were shown to alter adipocyte differentiation in cultured cells. We aimed to...
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From:Stem Cell Research & Therapy (Vol. 10, Issue 1) Peer-ReviewedObjective Although adipocytes are the most abundant stromal cell component in breast cancer tissues, their interaction with breast cancer cells has been less investigated compared to cancer-associated fibroblasts or...
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From:Diabetes (Vol. 57, Issue 5) Peer-ReviewedOBJECTIVE--Oxidative stress is associated with insulin resistance and is thought to contribute to progression toward type 2 diabetes. Oxidation induces cellular damages through increased amounts of reactive aldehydes...
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From:PLoS ONE (Vol. 14, Issue 5) Peer-ReviewedLipid droplets are lipid-storage organelles with a key role in lipid accumulation pathologies such as diabetes, obesity and atherosclerosis. Despite their important functions many aspects of lipid droplets biology are...
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From:Journal of Animal Science and Technology (Vol. 59, Issue 1) Peer-ReviewedBackground Intrauterine environment plays a pivotal role in the origin of fatal diseases such as the metabolic syndrome. Diabetes is associated with low-grade inflammatory state and dysregulated adipokines...
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From:PLoS ONE (Vol. 12, Issue 2) Peer-ReviewedLong noncoding RNAs (lncRNAs) regulate metabolic tissue development and function, including adipogenesis. However, little is known about the function and profile of lncRNAs in intramuscular preadipocyte differentiation...
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From:The Scientist (Vol. 14, Issue 17) Peer-ReviewedUnderstanding the pathway for fat cell development could help scientists learn how and why obesity occurs. Taking a step toward this goal, Ormond MacDougald, assistant professor of physiology at the University of...
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From:Phytomedicine: International Journal of Phytotherapy & Phytopharmacology (Vol. 16, Issue 9) Peer-ReviewedAbstract It is known that a number of transcription factors are key regulators in the complex process of adipocyte differentiation including peroxisome proliferator activated receptor [gamma] (PPAR[gamma]) and the...
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From:Diabetes (Vol. 53, Issue 5) Peer-ReviewedRecently, it was shown that caveolin-1 can be redirected from the cell surface to intracellular lipid droplets in a variety of cell types. Here, we directly address the role of caveolin-1 in lipid droplet formation and...
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From:Diabetes (Vol. 53, Issue 9) Peer-ReviewedAMP-activated protein kinase (AMPK) is considered as a cellular energy sensor that regulates glucose and lipid metabolism by phosphorylating key regulatory enzymes. Despite the major role of adipose tissue in regulating...
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From:European Journal of Clinical Nutrition (Vol. 72, Issue 10) Peer-ReviewedAuthor(s): Thorkild I. A. Sørensen 1 2 Author Affiliations: (1) Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, University of Copenhagen, Copenhagen, Denmark (2)...
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From:Diabetes (Vol. 48, Issue 4) Peer-ReviewedPeroxisome proliferator-activated receptor (PPAR)-[Gamma] is one of the key actors of adipocyte differentiation. This study demonstrates 1) that PPAR-[Gamma] mRNA expression is not altered in subcutaneous adipose tissue...
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From:Diabetes Care (Vol. 26, Issue 8) Peer-ReviewedRecent research has shown that adipose tissue is not simply an inert storage depot for lipids but is also an important endocrine organ that plays a key role in the integration of endocrine, metabolic, and inflammatory...
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From:Phytomedicine: International Journal of Phytotherapy & Phytopharmacology (Vol. 22, Issue 6) Peer-ReviewedABSTRACT Background: Currently, more than one-third of the global population is overweight or obese, which is a risk factor for major causes of death including cardiovascular disease, numerous cancers, and diabetes....
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From:Environmental Health Perspectives (Vol. 116, Issue 6) Peer-ReviewedBACKGROUND: Obesity, an inflammatory condition linked to cardiovascular disease, is associated with expansion of adipose tissue. Highly prevalent coplanar polychlorinated biphenyls (PCBs) such as 3,3',...
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From:Diabetes (Vol. 55, Issue 12) Peer-ReviewedAdipose tissue secretes factors that control various physiological systems. The fall in leptin during fasting mediates hyperphagia and suppresses thermogenesis, thyroid and reproductive hormones, and immune system. On...