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Academic Journals
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From:Oxidative Medicine and Cellular Longevity (Vol. 2018) Peer-ReviewedHyperglycaemia-induced oxidative stress appears to be involved in the aetiology of diabetic retinopathy (DR), a major public health issue, via altering DNA methylation process. We investigated the effect of...
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From:BioMed Research International (Vol. 2018) Peer-ReviewedObjective. The aim of this study was to evaluate the influence of adalimumab on expression profile of genes associated with the histaminergic system in Normal Human Dermal Fibroblast (NHDF) cells stimulated with 8.00...
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From:PLoS ONE (Vol. 15, Issue 4) Peer-ReviewedMyocardial fibrosis is often associated with cardiac hypertrophy; indeed, fibrosis is one of the most critical factors affecting prognosis. We aimed to identify the molecules involved in promoting fibrosis under...
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From:ALTEX: Alternatives to Animal Experimentation (Vol. 37, Issue 1) Peer-ReviewedLifestyle and genetic factors can lead to the development of atherosclerosis and, ultimately, cardiovascular adverse events. Rodent models are commonly used to investigate mechanism(s) of atherogenesis. However, the 3R...
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From:PLoS ONE (Vol. 14, Issue 12) Peer-ReviewedLeptospira genus contains species that affect human health with varying degrees of pathogenicity. In this context, we aimed to evaluate the differences in the modulation of host gene expression by strains of Leptospira...
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From:BioMed Research International (Vol. 2020) Peer-ReviewedThe peroxiredoxin (PRDX) gene family has been reported to participate in regulating occurrence and development of cancerous diseases, but its exact prognostic values in gastric cancer (GC) remain largely elusive. In the...
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From:Stem Cell Research & Therapy (Vol. 11, Issue 1) Peer-ReviewedBackground Retinal degeneration is a leading cause of blindness in the world; its etiology is complex and involves genetic defects and stress-associated aging. In addition to gene therapies for known genetically...
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From:BioMed Research International (Vol. 2018) Peer-ReviewedObjective. Icariin plays a pivotal role in ameliorating atherosclerosis for animal models although its comprehensive biological role remains largely unexplored. This study aimed to fully understand the effects of icariin...
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From:BioMed Research InternationalPeer-ReviewedBackground. Idiopathic pulmonary fibrosis (IPF), the most common interstitial lung disease, arises from transforming growth factor beta 1- (TGF[beta]1-) induced aberrant fibroproliferation in response to epithelial...
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From:PLoS ONE (Vol. 14, Issue 12) Peer-ReviewedVisceral Leishmaniasis is a chronic zoonosis and, if left untreated, can be fatal. Infected dogs have decreased cellular immunity (Th1) and develop a potent humoral response (Th2), which is not effective for elimination...
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From:Journal of Immunology Research (Vol. 2021) Peer-ReviewedBackground. Diffuse large B cell lymphoma (DLBCL) is a life-threatening malignant tumor characterized by heterogeneous clinical, phenotypic, and molecular manifestations. Given the association between immunity and...
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From:Journal of Immunology Research (Vol. 2019) Peer-ReviewedAdult-onset Still's disease (AOSD) is a rare and inflammatory disorder characterized by spiking fever, rash, arthritis, and multisystemic involvement. HLA has been shown to be associated with AOSD; however, it could not...
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From:Genetics Selection Evolution (Vol. 51, Issue 1) Peer-ReviewedBackground The main aim of single-step genomic predictions was to facilitate optimal selection in populations consisting of both genotyped and non-genotyped individuals. However, in spite of intensive research, biases...
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From:eLife (Vol. 9) Peer-ReviewedStaphylococcus aureus (S. aureus) is a common colonizer of healthy skin and mucous membranes. At the same time, S. aureus is the most frequent cause of skin and soft tissue infections. Dermal macrophages (M[phi]) are...
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From:BioMed Research International (Vol. 2018) Peer-ReviewedBackground. In the pathogenesis of atherosclerosis, a central role is represented by endothelial inflammation with influx of chemokine-mediated leukocytes in the vascular wall. Aim of this study was to analyze the effect...
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From:International Journal of Retina and Vitreous (Vol. 7, Issue 1) Peer-ReviewedBackground Patients with 13q-syndrome are at risk of retinoblastoma when the RB1 gene, located in the chromosomal band 13q14.2, is deleted. This syndrome is frequently associated with congenital malformations and...
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From:Journal of Oncology (Vol. 2020) Peer-ReviewedBackground. Pancreatic cancer is a devastating disease; its lethality is related to rapid growth and tendency to invade adjacent organs and metastasize at an early stage. Objective. The aim of this study was to identify...
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From:PLoS ONE (Vol. 17, Issue 5) Peer-ReviewedBackground Although gene-expression (GE) and protein levels are typically strongly genetically regulated, their correlation is known to be low. Here we investigate this phenomenon by focusing on the genetic background...
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From:Brazilian Journal of Medical and Biological Research (Vol. 54, Issue 8) Peer-ReviewedEsophageal squamous cell carcinoma (ESCC) is among the ten most frequent and deadly cancers, without effective therapies for most patients. More recently, drugs targeting deregulated growth factor signaling receptors...
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From:BioMed Research InternationalPeer-ReviewedBreast cancer is the most common cancer observed in adult females, worldwide. Due to the heterogeneity and varied molecular subtypes of breast cancer, the molecular mechanisms underlying carcinogenesis in different...