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Academic Journals
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From:Diabetes (Vol. 54, Issue 11) Peer-ReviewedIn 15-month-old db/db mice, signs of diabetic retinopathy, including blood-retinal barrier breakdown, loss of pericytes, neuro-retinal apoptosis, glial reactivation, and proliferation of blood vessels, were evident....
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From:Oxidative Medicine and Cellular Longevity (Vol. 2015) Peer-ReviewedBased on the crucial roles of oxidative stress and aldose reductase on diabetic complications and the protective effect against diabetic eye complication of purple waxy corn and ginger (PWCG) together with the...
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From:Diabetes (Vol. 49, Issue 5) Peer-ReviewedReports indicate that effects of aldose reductase inhibitors (ARIs) and antioxidants in experimental diabetic neuropathy are unidirectional i.e. both agents correct vascular dysfunction, conduction deficits, metabolic...
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From:Phytomedicine: International Journal of Phytotherapy & Phytopharmacology (Vol. 14, Issue 7-8) Peer-ReviewedAbstract Two dihydroflavonol glycosides, engeletin and astilbin, were isolated from an EtOAc extract of the leaves of Stelechocarpus cauliflorus R.E. Fr. (Annonaceae). The inhibitory activity of engeletin against a...
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From:Diabetes (Vol. 46, Issue 2) Peer-ReviewedDiabetes increases the incidence of cardiovascular disease as well as the complications of myocardial infarction. Studies using animal models of diabetes have demonstrated that the metabolic alterations occurring at the...
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From:Journal of Diabetes Research (Vol. 2016) Peer-ReviewedDetermining the liver changes during the early stages of diabetes is critical to understand the nature of the disease and development of novel treatments for it. Advances in the use of animal models and next-generation...
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From:Journal of Diabetes Research (Vol. 2016) Peer-ReviewedThis study investigated the effects of the new aldose reductase inhibitor benzofuroxane derivative 5(6)-(benzo[d]thiazol-2-ylmethoxy)benzofuroxane (BF-5m) on the prolongation of cardiac QT interval and increase of...
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From:Diabetes (Vol. 53, Issue 11) Peer-ReviewedThe expression of nephropathy in type 2 diabetes has several levels of abnormalities. To define the primary abnormalities of diabetic nephropathy, we conducted an autopsy study of 186 consecutive patients with type 2...
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From:Oxidative Medicine and Cellular Longevity (Vol. 2015) Peer-Reviewed[NAD.sup.+] is important for oxidative metabolism by serving as an electron transporter. Hyperglycemia decreases [NAD.sup.+] levels by activation of the polyol pathway and by overactivation of...
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From:Diabetes Forecast (Vol. 42, Issue 5)Aldose Reductase Inhibitors & Diabetic Neuropathy The newspaper headline was an eye-catcher: "New Cure For Neuropathy, Retinopathy, and Kidney Failure." The researchers quoted compared their work to the discovery of...
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From:PLoS ONE (Vol. 7, Issue 12) Peer-ReviewedAuthor(s): Peter F. Kador 1 , 2 , * , Peng Zhang 1 , Jun Makita 1 , Zifeng Zhang 1 , Changmei Guo 1 , James Randazzo 1 , Hiroyoshi Kawada 1 , Neena Haider 2 , 3 , Karen Blessing 1 Introduction Diabetic Retinopathy...
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From:Diabetes (Vol. 48, Issue 6) Peer-ReviewedA [(CA).sub.n] dinucleotide repeat sequence -2.1 kb upstream of the transcription start site of the aldose reductase gene has been found to be strongly associated with human diabetic nephropathy and retinopathy (1,2)...
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From:Diabetes (Vol. 38, Issue 11) Peer-ReviewedNerve water content and the permeability-surface area product (PA) to [H]- or [14C]sucrose at the blood-nerve barrier were determined in unanesthetized control rats fed a normal diet and in rats fed galactose with or...
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From:Diabetes (Vol. 42, Issue 6) Peer-ReviewedTo investigate a possible role of excessive polyol production in the pathogenesis of diabetic retinopathy, 16 ALX-induced diabetic dogs and 20 experimentally galactosemic dogs were randomly assigned to 5 yr of treatment...
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From:Diabetes Forecast (Vol. 46, Issue 3)This past summer, Larry DeLucas spent 14 days up in the space shuttle Columbia to do his bit to prevent diabetes-related complications. DeLucas isn't an astronaut; he's a crystallographer. He grows delicate crystals...
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From:Journal of Research in Medical Sciences (Vol. 26, Issue 1) Peer-ReviewedByline: Diala. Abu-Hassan, Muawyah. Al-Bdour, Ibraheem. Saleh, Mona. Freihat, Mohammed. El-Khateeb Background: Hyperglycemia over-activates glucose reduction to sorbitol by aldose reductase (ALR) leading to...
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From:Veterinary World (Vol. 15, Issue 7)Background and Aim: The oviduct environment is of particular importance because it is the site of fertilization and early embryo development. The oviduct, as a component of the reproductive system, responds to ovarian...
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From:Diabetes (Vol. 49, Issue 5) Peer-ReviewedPrevious studies have shown that increased flux through the polyol pathway is intricately involved in the pathogenesis of diabetic nephropathy and other microvascular complications. Aldose reductase (ALR2) is the first...
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From:Journal of Diabetes Research (Vol. 2017) Peer-ReviewedWe have shown earlier that pretreatment of cultured cells with aldose reductase (AR) inhibitors prevents hyperglycemia-induced mitogenic and proinflammatory responses. However, the effects of AR inhibitors on...
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From:PeerJ (Vol. 5) Peer-ReviewedBackground The wood frog, Rana sylvatica, tolerates freezing as a means of winter survival. Freezing is considered to be an ischemic/anoxic event in which oxygen delivery is significantly impaired. In addition,...