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    Academic Journals

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• What is the ideal dose of protein substitute in phenylketonuria (PKU)?

  Authors:A. MacDonald, A. Daly, A. Chakrapani, G. Rylance, D. Asplin, S.K. Hall, et al.From:Archives of Disease in Childhood (Vol. 89, Issue 4) Peer-Reviewed

  Apr. 2004314 words Brief article Introduction: The optimal dosage of protein substitute (PS) has not been determined in PKU and there is much international disagreement. Aim: To determine if a lower dose of PS could achieve the same or better level...

• Loss of potentiating effect of hypoglycemia on the glucagon response to hyperaminoacidemia in IDDM

  Authors:Sonia Caprio, William V. Tamborlane, Kathleen Zych, Karen Gerow, and Robert S. SherwinFrom:Diabetes (Vol. 42, Issue 4) Peer-Reviewed

  Apr. 19933,314 words Article IDDM subjects lose the ability to release glucagon during hypoglycemia. Because replacement of basal levels of amino acids enhances the glucagon response to hypoglycemia in healthy subjects, we tested whether raising...

• Adipose Tissue Dysfunction and Altered Systemic Amino Acid Metabolism Are Associated with Non-Alcoholic Fatty Liver Disease

  Authors:Sulin Cheng, Petri Wiklund, Reija Autio, Ronald Borra, Xiaowei Ojanen, Leiting Xu, et al.From:PLoS ONE (Vol. 10, Issue 10) Peer-Reviewed

  Oct. 6, 20158,210 words Report 1430LBackground Fatty liver is a major cause of obesity-related morbidity and mortality. The aim of this study was to identify early metabolic alterations associated with liver fat accumulation in 50- to 55-year-old men...

• The catalytic machinery of a key enzyme in amino acid biosynthesis

  Authors:Ronald E. Viola, Christopher R. Faehnle, Julio Blanco, Roger A. Moore, Xuying Liu, Buenafe T. Arachea, et al.From:Journal of Amino AcidsPeer-Reviewed

  Annual 20116,788 words Report 1560LThe aspartate pathway of amino acid biosynthesis is essential for all microbial life but is absent in mammals. Characterizing the enzyme-catalyzed reactions in this pathway can identify new protein targets for the...

• Arsenic deprivation affects homocysteine remethylation in rats fed homocystine and choline. (Professional Communications)

  Author:Eric O. UthusFrom:Proceedings of the North Dakota Academy of SciencePeer-Reviewed

  Apr. 2001392 words Brief article Dietary arsenic (As) is thought to have a physiological role in methionine (Meth) metabolism (1). Some findings suggest that arsenic may be important in the remethylation of homocysteine to methionine. There are two...

• Elevated levels of kynurenic acid in the cerebrospinal fluid of patients with bipolar disorder

  Authors:Sara K. Olsson, Martin Samuelsson, Peter Saetre, Leif Lindstrom, Erik G. Jonsson, Conny Nordin, et al.From:Journal of Psychiatry and Neuroscience (Vol. 35, Issue 3) Peer-Reviewed

  May 20103,890 words Report Background: Patients with schizophrenia show elevated brain levels of the neuroactive tryptophan metabolite kynurenic acid (KYNA). This astrocyte-derived mediator acts as a neuroprotectant and modulates sensory gating...

• Pharmacological manipulation of kynurenic acid: potential in the treatment of psychiatric disorders

  Authors:Sophie Erhardt, Sara K. Olsson, and Goran EngbergFrom:CNS Drugs (Vol. 23, Issue 2) Peer-Reviewed

  Feb. 20097,286 words Report 2110LThe kynurenine pathway constitutes the main route of tryptophan degradation and generates the production of several neuroactive compounds; quinolinic acid is an excitotoxic NMDA receptor agonist, 3-hydroxykynurenine is...

• Whitefly Genome Expression Reveals Host-Symbiont Interaction in Amino Acid Biosynthesis

  Authors:Santosh Kumar Upadhyay, Shailesh Sharma, Harpal Singh, Sameer Dixit, Jitesh Kumar, Praveen C Verma, et al.From:PLoS ONE (Vol. 10, Issue 5) Peer-Reviewed

  May 22, 20156,437 words Report 1420LBackground Whitefly (Bemisia tabaci) complex is a serious insect pest of several crop plants worldwide. It comprises several morphologically indistinguishable species, however very little is known about their genetic...

• The .sup.15N-leucine single-injection method allows for determining endogenous losses and true digestibility of amino acids in cecectomized roosters

  Authors:Rujiu Hu, Jing Li, Rab Nawaz Soomro, Fei Wang, Yan Feng, Xiaojun Yang, et al.From:PLoS ONE (Vol. 12, Issue 11) Peer-Reviewed

  Nov. 22, 20175,135 words Report 1480LThis study was conducted to assess the influence of dietary protein content in poultry when using the .sup.15 N-leucine single-injection method to determine endogenous amino acid losses (EAALs) in poultry. Forty-eight...

• HPN-100

  From:Formulary (Vol. 46, Issue 1) Peer-Reviewed

  Jan. 201116 words Brief article 1260LGlycerol phenylbutyrate (HPN-100, Hyperion Therapeutics) as adjunctive therapy for the chronic management of urea cycle disorders....

• Implication of the polyamine system in mental disorders

  Authors:Laura M. Fiori and Gustavo TureckiFrom:Journal of Psychiatry and Neuroscience (Vol. 33, Issue 2) Peer-Reviewed

  Mar. 20085,760 words Clinical report 2210LThe polyamine pathway has an essential role in many cellular functions and has been implicated in several pathological conditions. Accumulating evidence suggests that the polyamine system also plays a role in the...

• Homocysteine in cardiovascular disease: A culprit or an innocent bystander?

  Author:Mudgal KothekarFrom:Indian Journal of Medical Sciences (Vol. 61, Issue 6) Peer-Reviewed

  June 20074,566 words Article 1530LByline: Mudgal. Kothekar Whether hyperhomocysteinemia is a cardiovascular risk factor or is just an epiphenomenon is a subject of debate. More than 20 prospective and 30 retrospective studies on the topic have been...

• Extracting copper. (Biochemistry)

  From:Science (Vol. 296, Issue 5568) Peer-Reviewed

  Apr. 26, 2002212 words Brief article In Enterococcus hirae, the cop operon encodes the copper chaperone CopZ and the transcription factor CopY. At low ambient copper, CopY binds Zn(II) and blocks expression of the entire operon; when copper is present,...

• Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes

  Authors:Weijia Xie, Andrew R. Wood, Valeriya Lyssenko, Michael N. Weedon, Joshua W. Knowles, Sami Alkayyali, et al.From:Diabetes (Vol. 62, Issue 6) Peer-Reviewed

  June 20136,149 words Report 1390LCirculating metabolites associated with insulin sensitivity may represent useful biomarkers, but their causal role in insulin sensitivity and diabetes is less certain. We previously identified novel metabolites...

• Protein: what's on in research on clinical nutrition

  Author:Daniel TomeFrom:European Journal of Clinical Nutrition (Vol. 72, Issue 9) Peer-Reviewed

  Sept. 20185,300 words Report 1760LAuthor(s): Daniel Tomé 1 Author Affiliations: (1) PNCA, INRA, AgroParisTech, Université Paris-Saclay, Paris, France Introduction Proteins are dietary components indispensable for maintenance and survival....

• Oxytocin-induced increase in N,N-dimethylglycine and time course of changes in oxytocin efficacy for autism social core symptoms.

  Authors:Yasuhiko Kato, Hitoshi Kuwabara, Takashi Okada, Toshio Munesue, Seico Benner, Miho Kuroda, et al.From:Molecular Autism (Vol. 12, Issue 1) Peer-Reviewed

  Feb. 23, 20217,324 words Report 1620LBackground Oxytocin is expected as a novel therapeutic agent for autism spectrum disorder (ASD) core symptoms. However, previous results on the efficacy of repeated administrations of oxytocin are controversial....

• The nutri-genomic impact on histamine metabolism

  Author:Brett WisniewskiFrom:Original Internist (Vol. 22, Issue 3) Peer-Reviewed

  Sept. 20152,256 words Article 1270LHistamine is a 5-carbon nitrogenous substance that has an immune-modulatory role most known for the "allergic reaction." Histamine is well documented in other conditions such as Meniere's disease, irritable bowel...

• Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced [beta]-cell mass

  Authors:Simone Renner, Werner Romisch-Margl, Cornelia Prehn, Stefan Krebs, Jerzy Adamski, Burkhard Goke, et al.From:Diabetes (Vol. 61, Issue 8) Peer-Reviewed

  Aug. 20126,151 words Report 1550LDiabetes is generally diagnosed too late. Therefore, biomarkers indicating early stages of [beta]-cell dysfunction and mass reduction would facilitate timely counteraction. Transgenic pigs expressing a dominant-negative...

• BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1

  Authors:Martje Tonjes, Sebastian Barbus, Yoon Jung Park, Wei Wang, Magdalena Schlotter, Anders M. Lindroth, et al.From:Nature Medicine (Vol. 19, Issue 7) Peer-Reviewed

  July 20138,807 words Report 1520LHere we show that glioblastoma express high levels of branched-chain amino acid transaminase 1 (BCAT1), the enzyme that initiates the catabolism of branched-chain amino acids (BCAAs). Expression of BCAT1 was exclusive...

• Methionine Biosynthesis is Essential for Infection in the Rice Blast Fungus Magnaporthe oryzae

  Authors:Marie Emmanuelle Saint-Macary, Crystel Barbisan, Marie Josephe Gagey, Oceane Frelin, Roland Beffa, Marc Henri Lebrun, et al.From:PLoS ONE (Vol. 10, Issue 4) Peer-Reviewed

  Apr. 9, 201510,259 words Report 1470LMethionine is a sulfur amino acid standing at the crossroads of several biosynthetic pathways. In fungi, the last step of methionine biosynthesis is catalyzed by a cobalamine-independent methionine synthase (Met6, EC...