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From:Journal of Clinical Investigation (Vol. 120, Issue 5) Peer-ReviewedRegulation of sodium balance is a critical factor in the maintenance of euvolemia, and dysregulation of renal sodium excretion results in disorders of altered intravascular volume, such as hypertension. The...
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From:LC-GC North America (Vol. 20, Issue 2) Peer-ReviewedIon chromatography eluent generation and anion-exchange columns with 5-[micro]m particle size can be used to determine sub-[micro]g/L anions in high purity water by large-loop injection. ********** This document...
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From:Pharmacogenomics (Vol. 12, Issue 5) Peer-ReviewedAuthor(s): Kaixin Zhou 1 , Ewan R Pearson [[dagger]â ] 2 Metformin is recommended by all guidelines as the first-line oral therapy in the treatment of Type 2 diabetes, and it is currently used by over 100 million...
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From:LC-GC North America (Vol. 20, Issue 2) Peer-ReviewedHamilton Company is best known for manufacturing precision fluid-measuring products, including syringes for HPLC and GC. Unknown to most people, for the last 25 years Hamilton Company has manufactured HPLC resins and...
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From:Crop Science (Vol. 42, Issue 4) Peer-ReviewedAnion exchange membranes (AEMs) are a potential method for determining the plant available N status of soils; however, their capacity for use with turfgrass has not been researched extensively. The main objective of...
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From:Archives of Industrial Hygiene and Toxicology (Vol. 66, Issue 3) Peer-ReviewedCFEX (chloride/formate exchanger; Slc26a6) is an important anion exchanger of chloride, bicarbonate, oxalate (OX), formate, and hydroxyl ions in kidneys, liver, and the small intestine. Studies on CFEX-knockout mice...
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From:Forensic Science International (Vol. 146, Issue 1) Peer-ReviewedAbstract The aim of the study was to test combinations of commercially available carbohydrate-deficient transferrin (CDT) assays for their usefulness as screening and confirmatory CDT analysis systems. A set of 292...
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From:Nature (Vol. 499, Issue 7456) Peer-ReviewedEukaryotic [Ca.sup.2+] regulation involves sequestration into intracellular organelles, and expeditious [Ca.sup.2+] release into the cytosol is a hallmark of key signalling transduction pathways. Bulk removal of...
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From:Biochemistry and Cell Biology (Vol. 88, Issue 2) Peer-Reviewed
Cell surface rescue of kidney anion exchanger 1 mutants through disruption of chaperone interactions
Mutations in the human kidney anion exchanger 1 (kAE1) membrane glycoprotein cause impaired urine acidification in the disease distal renal tubular acidosis (dRTA). Dominant and recessive mutants of kAE1 exhibit... -
From:Journal of Clinical Investigation (Vol. 120, Issue 6) Peer-ReviewedAmmonia absorption by the medullary thick ascending limb of Henle's loop (MTALH) is thought to be a critical step in renal ammonia handling and excretion in urine, in which it is the main acid component. Basolateral...
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From:Biochemistry and Cell Biology (Vol. 89, Issue 2) Peer-ReviewedWe recently published the three-dimensional structure of the membrane domain of human erythrocyte anion exchanger 1 (AE1) at 7.5 A resolution, solved by electron crystallography. The structure exhibited distinctive...