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    Academic Journals

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• Somatic mutations reveal asymmetric cellular dynamics in the early human embryo

  Authors:Young Seok Ju, Inigo Martincorena, Moritz Gerstung, Mia Petljak, Ludmil B. Alexandrov, Raheleh Rahbari, et al.From:Nature (Vol. 543, Issue 7647) Peer-Reviewed

  Mar. 30, 201711,330 words Report 1600LAuthor(s): Young Seok Ju [1, 2]; Inigo Martincorena [1]; Moritz Gerstung [1, 3]; Mia Petljak [1]; Ludmil B. Alexandrov [1, 4]; Raheleh Rahbari [5]; David C. Wedge [1, 6]; Helen R. Davies [1]; Manasa Ramakrishna [1];...

• Somatic freeshift mutations in the BAX gene in colon cancers of the microsatellite mutator phenotype

  Authors:Nicholas Rampino, Hiroyuki Yamamoto, Yurij Ionov, Yan Li, Hisako Sawai, John C. Reed, et al.From:Science (Vol. 275, Issue 5302) Peer-Reviewed

  Feb. 14, 19972,341 words Article Cancers of the microsatellite mutator phenotype (MMP) show exaggerated genomic instability at simple repeat sequences. More than 50 percent (21 out of 41) of human [MMP.sup.+] colon adenocarcinomas examined were found to...

• RNA Editing AIDs Antibody Diversification?

  Authors:Michael S. Neuberger and James ScottFrom:Science (Vol. 289, Issue 5485) Peer-Reviewed

  Sept. 8, 2000979 words Brief article The B lymphocytes of the immune system use multiple genetic mechanisms--gene rearrangement, somatic hypermutation, and gene conversion--to drive the generation of antibody diversity. Now, Honjo and colleagues (1) and...

• Antibody and immunoglobulin diversity

  Authors:Gary W. Litman, Chris T. Amemiya, Robert N. Haire, and Michael J. ShamblottFrom:BioScience (Vol. 40, Issue 10) Peer-Reviewed

  Nov. 19904,855 words Article Antibody and Immunoglobulin Diversity Immunoglobulin (antibody) genes have been identified in extant species that are representative of critical points in the evolutionary radiations of vertebrates. The role of...

• The product of the human c-erbB-2 gene; a 185-kilodation glycoprotein with tyrosine kinase activity

  Authors:Tetsu Akiyama, Chie Sudo, Hiroshi Ogawara, Kumao Toyoshima, and Tadashi YamamotoFrom:Science (Vol. 232) Peer-Reviewed

  June 27, 19861,102 words Article The Product of the Human c-erbB-2 Gene: A 185-Kilodalton Glycoprotein with Tyrosine Kinase Activity THE V-ERBB GENE IS AN ONCOGENE of avian erythroblastosis virus, which induces erythroblastosis and sarcomas in...

• High-mobility group A1 inhibits p53 by cytoplasmic relocalization of its proapoptotic activator HIPK2

  Authors:Giovanna Maria Pierantoni, Cinzia Rinaldo, Marcella Mottolese, Anna Di Benedetto, Francesco Esposito, Silvia Soddu, et al.From:Journal of Clinical Investigation (Vol. 117, Issue 3) Peer-Reviewed

  Mar. 20076,022 words Article 1440LHigh-mobility group A1 (HMGA1) overexpression and gene rearrangement are frequent events in human cancer, but the molecular basis of HMGA1 oncogenic activity remains unclear. Here we describe a mechanism through which...

• Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi

  Authors:Catherine D. Van Raamsdonk, Vladimir Bezrookove, Gary Green, Jurgen Bauer, Lona Gaugler, Joan M. O'Brien, et al.From:Nature (Vol. 457, Issue 7229) Peer-Reviewed

  Jan. 29, 20093,742 words Report 1440LBRAF and NRAS are common targets for somatic mutations in benign and malignant neoplasms that arise from melanocytes situated in epithelial structures, and lead to constitutive activation of the mitogen-activated...

• Unusual immunoglobulin gene rearrangement leads to replacement of recombinational signal sequences

  Authors:Ewa Morzycka-Wroblewska, F. Eun Hyung Lee, and Stephen V. DesiderioFrom:Science (Vol. 242, Issue 4876) Peer-Reviewed

  Oct. 14, 19881,433 words Article Unusual Immunoglobulin Gene Rearrangement Leads to Replacement of Recombinational Signal Sequences THE VARIABLE REGIONS OF IMMUNOGLOBULIN (Ig) heavy chains are encoded in three separate DNA segments, V.sub.H., D, and...

• Germ-line transmission of a c-abl mutation produced by targeted gene disruption in ES cells

  Authors:Pamela L. Schwartzberg, Stephen P. Goff, and Elizabeth J. RobertsonFrom:Science (Vol. 246, Issue 4931) Peer-Reviewed

  Nov. 10, 19894,433 words Article Germ-Line Transmission of a c-abl Mutation Produced by Targeted Gene Disruption in ES Cells THE INTRODUCTION OF MUTATIONS into the germ line of an organism is one of the most powerful genetic methods for determining...

• The diverse and dynamic structure of bacterial genomes

  Author:Sherwood CasjensFrom:Annual Review of Genetics (Vol. 32) Peer-Reviewed

  Annual 199813,503 words Article Structural variations among bacterial genomes have been investigated at inter- and intraspecies levels. Specifically, plasticity in structure of bacterial genomes as well as diversity in genome size, chromosome number...

• Evidence for increased somatic cell mutations at the glycophorin A locus in atomic bomb survivors

  Authors:Richard G. Langlois, William L. Bigbee, Seishi Kyoizumi, Nori Nakamura, Michael A. Bean, Mitoshi Akiyama, et al.From:Science (Vol. 236) Peer-Reviewed

  Apr. 24, 19873,380 words Article Evidence for Increased Somatic Cell Mutations at the Glycophorin A Locus in Atomic Bomb Survivors THERE IS CONTINUING INTEREST INevaluating the long-term health effects of human exposure to ionizing radiation (1) and...

• Somatic growth of a school-aged population from Mozambique: trend and biosocial meaning

  Authors:A. Prista, A.J.R. Maia, S. Saranga, L. Nhantumbo, A.T. Marques, and G. BeunenFrom:Human Biology (Vol. 77, Issue 4) Peer-Reviewed

  Aug. 20053,874 words Article A cross-sectional study of children and adolescents from Maputo, Mozambique, was carried out in order to (1) describe the current growth status of children and adolescents from Maputo, (2) evaluate the relative status...

• Mechanisms and therapeutic implications of hypermutation in gliomas.

  Authors:Mehdi Touat, Yvonne Y. Li, Adam N. Boynton, Liam F. Spurr, J. Bryan Iorgulescu, Craig L. Bohrson, et al.From:Nature (Vol. 580, Issue 7804) Peer-Reviewed

  Apr. 23, 202018,151 words Technical report 1580LA high tumour mutational burden (hypermutation) is observed in some gliomas.sup.1-5; however, the mechanisms by which hypermutation develops and whether it predicts the response to immunotherapy are poorly understood....

• Development of the primary antibody repertoire

  Authors:Frederick W. Alt, T. Keith Blackwell, and George D. YancopoulosFrom:Science (Vol. 238, Issue 4830) Peer-Reviewed

  Nov. 20, 198710,088 words Article Development of the Primary Antibody Repertoire HUMORAL IMMUNITY IN VERTEBRATES IS EFFECTED BY antigen-binding antibody [or immunoglobulin (Ig)] molecules that are secreted by cells of the B lymphocyte lineage. The...

• Reconstruction of 3D structures of MET antibodies from electron microscopy 2D class averages

  Authors:Qi Chen, Michal Vieth, David E. Timm, Christine Humblet, Dina Schneidman-Duhovny, Ilan E. Chemmama, et al.From:PLoS ONE (Vol. 12, Issue 4) Peer-Reviewed

  Apr. 13, 20176,539 words Report 1440LDynamics of three MET antibody constructs (IgG1, IgG2, and IgG4) and the IgG4-MET antigen complex was investigated by creating their atomic models with an integrative experimental and computational approach. In...

• B-Cell Pulmonary Lymphoma

  Authors:Bruno Philippe, Marie-Helene Delfau-Larue, Bernard Epardeau, Brigitte Autran, Jean-Pierre Clauvel, Jean-Pierre Farcet, et al.From:Chest (Vol. 115, Issue 5) Peer-Reviewed

  May 19992,979 words Article Gene Rearrangement Analysis of Bronchoalveolar Lymphocytes by Polymerase Chain Reaction Study objectives: Non-Hodgkin's lymphomas (NHLs) are clonal proliferation of B or T lymphocytes. Assessment of clonality in...

• T cell receptor gene trans-rearrangements: chimeric gamma-delta genes in normal lymphoid tissues

  Authors:Benjamin Tycko, James D. Palmer, and Jeffery SklarFrom:Science (Vol. 245, Issue 4923) Peer-Reviewed

  Sept. 15, 19893,126 words Article T Cell Receptor Gene Trans-Rearrangements: Chimeric [gamma]-[delta] Genes in Normal Lymphoid Tissues ANTIGEN RECEPTOR GENE REARRANGEMENT has generally been considered to occur during normal lymphocyte development...

• Benchmarking of T cell receptor repertoire profiling methods reveals large systematic biases.

  Authors:Pierre Barennes, Valentin Quiniou, Mikhail Shugay, Evgeniy S. Egorov, Alexey N. Davydov, Dmitriy M. Chudakov, et al.From:Nature Biotechnology (Vol. 39, Issue 2) Peer-Reviewed

  Feb. 20219,365 words Report 1450LMonitoring the T cell receptor (TCR) repertoire in health and disease can provide key insights into adaptive immune responses, but the accuracy of current TCR sequencing (TCRseq) methods is unclear. In this study, we...

• Codon-level co-occurrences of germline variants and somatic mutations in cancer are rare but often lead to incorrect variant annotation and underestimated impact prediction

  Authors:Amanda Koire, Young Won Kim, Jarey Wang, Panagiotis Katsonis, Haijing Jin, and Olivier LichtargeFrom:PLoS ONE (Vol. 12, Issue 3) Peer-Reviewed

  Mar. 28, 20175,586 words Report 1580LCancer cells explore a broad mutational landscape, bringing the possibility that tumor-specific somatic mutations could fall in the same codons as germline SNVs and leverage their presence to produce substitutions with...

• CD8+ cell somatic mutations in multiple sclerosis patients and controls-Enrichment of mutations in STAT3 and other genes implicated in hematological malignancies.

  Authors:Miko Valori, Lilja Jansson, and Pentti J. TienariFrom:PLoS ONE (Vol. 16, Issue 12) Peer-Reviewed

  Dec. 7, 20218,063 words Report 1560LSomatic mutations have a central role in cancer but their role in other diseases such as common autoimmune disorders is not clear. Previously we and others have demonstrated that especially CD8+ T cells in blood can...