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    Academic Journals

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• Sequence Polymorphism, Segmental Recombination and Toggling Amino Acid Residues within the DBL3X Domain of the VAR2CSA Placental Malaria Antigen

  Authors:Eldin Talundzic, Sheel Shah, Ope Fawole, Simon Owino, Julie M. Moore, and David S. PetersonFrom:PLoS ONE (Vol. 7, Issue 2) Peer-Reviewed

  Feb. 9, 20127,764 words Article 1560LAuthor(s): Eldin Talundzic 1 , Sheel Shah 1 , Ope Fawole 1 , Simon Owino 1 , Julie M. Moore 1 , 2 , David S. Peterson 1 , 2 , * Introduction Malaria in pregnancy is a disease syndrome with devastating social and...

• Small, N-Terminal Tags Activate Parkin E3 Ubiquitin Ligase Activity by Disrupting Its Autoinhibited Conformation

  Authors:Lynn Burchell, Viduth K. Chaugule, and Helen WaldenFrom:PLoS ONE (Vol. 7, Issue 4) Peer-Reviewed

  Apr. 4, 20123,368 words Article 1440LAuthor(s): Lynn Burchell, Viduth K. Chaugule ** , Helen Walden * Introduction Parkin is a RING E3 ubiquitin ligase [1], [2], [3] which, in conjunction with a ubiquitin-activating enzyme (E1) and a...

• Immunogenic and Invasive Properties of Brucella melitensis 16M Outer Membrane Protein Vaccine Candidates Identified via a Reverse Vaccinology Approach

  Authors:Gabriel Gomez, Jianwu Pei, Waithaka Mwangi, L. Garry Adams, Allison Rice-Ficht, and Thomas A. FichtFrom:PLoS ONE (Vol. 8, Issue 3) Peer-Reviewed

  Mar. 22, 20137,509 words Article 1570LAuthor(s): Gabriel Gomez 1 , * , Jianwu Pei 1 , Waithaka Mwangi 1 , L. Garry Adams 1 , Allison Rice-Ficht 1 , 2 , Thomas A. Ficht 1 Introduction Brucellosis is a zoonotic, chronic and debilitating systemic disease...

• Selection of conserved epitopes from hepatitis C virus for pan-populational stimulation of T-cell responses

  Authors:Magdalena Molero-Abraham, Esther M. Lafuente, Darren R. Flower, and Pedro A. RecheFrom:Journal of Immunology Research (Vol. 2013) Peer-Reviewed

  Annual 20135,505 words Article 1500LThe hepatitis C virus (HCV) is able to persist as a chronic infection, which can lead to cirrhosis and liver cancer. There is evidence that clearance of HCV is linked to strong responses by CD8 cytotoxic T lymphocytes...

• Enhancement of specific T-lymphocyte responses by monocyte-derived dendritic cells pulsed with E2 protein of human papillomavirus 16 and human p16INK4A.

  Authors:Nuchsupha Sunthamala, Neeranuch Sankla, Jureeporn Chuerduangphui, Piyawut Swangphon, Wanchareeporn Boontun, Supakpong Ngaochaiyaphum, et al.From:PeerJ (Vol. 8) Peer-Reviewed

  May 20, 20207,049 words Article 1450LIntroduction Prophylactic vaccines are already available for prevention of human papillomavirus (HPV) infection. However, we still await development of therapeutic vaccines with high efficiency for stimulating specific...

• Immunoinformatics approach for predicting epitopes in HN and F proteins of Porcine rubulavirus

  Authors:Luis I. Sianez-Estrada, Jose F. Rivera-Benitez, Nora H. Rosas-Murrieta, Julio Reyes-Leyva, Gerardo Santos-Lopez, and Irma Herrera-CamachoFrom:PLoS ONE (Vol. 15, Issue 9) Peer-Reviewed

  Sept. 25, 20207,082 words Report 1350LPorcine rubulavirus (PRV), which belongs to the family Paramyxoviridae, causes blue eye disease in pigs, characterized by encephalitis and reproductive failure in newborn and adult pigs, respectively. There is no...

• A Vaccine Encoding Conserved Promiscuous HIV CD4 Epitopes Induces Broad T Cell Responses in Mice Transgenic to Multiple Common HLA Class II Molecules

  Authors:Susan Pereira Ribeiro, Daniela Santoro Rosa, Simone Goncalves Fonseca, Eliane Conti Mairena, Edilberto Postol, Sergio Costa Oliveira, et al.From:PLoS ONE (Vol. 5, Issue 6) Peer-Reviewed

  June 11, 20106,957 words Article 1580LCurrent HIV vaccine approaches are focused on immunogens encoding whole HIV antigenic proteins that mainly elicit cytotoxic CD8+ responses. Mounting evidence points toward a critical role for CD4+ T cells in the control...

• The Evolutionary Selective Advantage of HIV-1 Escape Variants and the Contribution of Escape to the HLA-Associated Risk of AIDS Progression

  Author:Becca AsquithFrom:PLoS ONE (Vol. 3, Issue 10) Peer-Reviewed

  Oct. 22, 20087,869 words Article 1630LHIV-1 escape from surveillance by cytotoxic T lymphocytes (CTL) is thought to cause at least transient weakening of immune control. However, the CTL response is highly adaptable and the long-term consequences of viral...

• Design and Pre-Clinical Evaluation of a Universal HIV-1 Vaccine

  Authors:Sven Letourneau, Eung-Jun Im, Tumelo Mashishi, Choechoe Brereton, Anne Bridgeman, Hongbing Yang, et al.From:PLoS ONE (Vol. 2, Issue 10) Peer-Reviewed

  Oct. 3, 20078,777 words Article 1630LBackground One of the big roadblocks in development of HIV-1/AIDS vaccines is the enormous diversity of HIV-1, which could limit the value of any HIV-1 vaccine candidate currently under test. Methodology and...

• Genetic Diversity and Natural Selection of the Plasmodium knowlesi Circumsporozoite Protein Nonrepeat Regions

  Authors:Mun Yik Fong, Md Atique Ahmed, Shen Siang Wong, Yee Ling Lau, and Frankie SitamFrom:PLoS ONE (Vol. 10, Issue 9) Peer-Reviewed

  Sept. 17, 20155,776 words Article 1370LBackground Plasmodium knowlesi is a simian malaria parasite that has been identified to cause malaria in humans. To date, several thousand cases of human knowlesi malaria have been reported around Southeast Asia....

• Implications of CTL-Mediated Killing of HIV-Infected Cells during the Non-Productive Stage of Infection

  Authors:Christian L. Althaus and Rob J. De BoerFrom:PLoS ONE (Vol. 6, Issue 2) Peer-Reviewed

  Feb. 7, 20118,126 words Article 1660LPatients infected with HIV exhibit orders of magnitude differences in their set-point levels of the plasma viral load. As to what extent this variation is due to differences in the efficacy of the cytotoxic T lymphocyte...

• T Cell Intrinsic NOD2 Is Dispensable for CD8 T Cell Immunity

  Authors:Gloria H. Y. Lin, Michael E. Wortzman, Stephen E. Girardin, Dana J. Philpott, and Tania H. WattsFrom:PLoS ONE (Vol. 8, Issue 2) Peer-Reviewed

  Feb. 6, 20134,569 words Article 1740LNOD2 is an intracellular pattern recognition receptor that provides innate sensing of bacterial muramyl dipeptide by host cells, such as dendritic cells, macrophages and epithelial cells. While NOD2's role as an innate...

• Tracking the Antigenic Evolution of Foot-and-Mouth Disease Virus

  Authors:Richard Reeve, Daryl W. Borley, Francois F. Maree, Sasmita Upadhyaya, Azwidowi Lukhwareni, Jan J. Esterhuysen, et al.From:PLoS ONE (Vol. 11, Issue 7) Peer-Reviewed

  July 22, 20169,420 words Report 1670LQuantifying and predicting the antigenic characteristics of a virus is something of a holy grail for infectious disease research because of its central importance to the emergence of new strains, the severity of...

• Epitope Tags beside the N-Terminal Cytoplasmic Tail of Human BST-2 Alter Its Intracellular Trafficking and HIV-1 Restriction

  Authors:Mingyu Lv, Jiawen Wang, Jingyao Zhang, Biao Zhang, Xiaodan Wang, Yingzi Zhu, et al.From:PLoS ONE (Vol. 9, Issue 10) Peer-Reviewed

  Oct. 27, 201410,811 words Article 1530LBST-2 blocks the particle release of various enveloped viruses including HIV-1, and this antiviral activity is dependent on the topological arrangement of its four structural domains. Several functions of the...

• Cell Cycle-Dependent Phosphorylation of Theileria annulata Schizont Surface Proteins

  Authors:Olga Wiens, Dong Xia, Conrad von Schubert, Jonathan M. Wastling, Dirk A. E. Dobbelaere, Volker T. Heussler, et al.From:PLoS ONE (Vol. 9, Issue 7) Peer-Reviewed

  July 31, 20148,717 words Article 1500LThe invasion of Theileria sporozoites into bovine leukocytes is rapidly followed by the destruction of the surrounding host cell membrane, allowing the parasite to establish its niche within the host cell cytoplasm....

• MHC class I antigen cross-presentation mediated by PapMV nanoparticles in human antigen-presenting cells is dependent on autophagy.

  Authors:David Possamaï, Laïla-Aïcha Hanafi, Angélique Bellemare-Pelletier, Katia Hamelin, Paméla Thébault, Marie-Josée Hébert, et al.From:PLoS ONE (Vol. 16, Issue 12) Peer-Reviewed

  Dec. 31, 20219,689 words Report 1400LNanoparticles made of the coat protein of papaya mosaic virus (PapMV) and a single-strand RNA were previously shown to be an efficient antigen presentation system for the trigger of cellular immunity. Engineering of...

• Lactobacilli producing bispecific llama-derived anti-rotavirus proteins in vivo for rotavirus-induced diarrhea

  Authors:Neha Pant, Harold Marcotte, Pim Hermans, Sandra Bezemer, Leon Frenken, Kari Johansen, et al.From:Future Microbiology (Vol. 6, Issue 5)

  May 20115,978 words Article 1530LAuthor(s): Neha Pant 1 , Harold Marcotte 1 , Pim Hermans 2 , Sandra Bezemer 2 , Leon Frenken 3 , Kari Johansen 4 , Lennart Hammarström [[dagger]] 5 Keywords * antibodies; diarrhea; lactobacilli; passive...

• Fibrotic Remodeling of the Extracellular Matrix through a Novel (Engineered, Dual-Function) Antibody Reactive to a Cryptic Epitope on the N-Terminal 30 kDa Fragment of Fibronectin

  Authors:Maryada Sharma, Anil Tiwari, Shweta Sharma, Preeti Bhoria, Vishali Gupta, Amod Gupta, et al.From:PLoS ONE (Vol. 8, Issue 7) Peer-Reviewed

  July 23, 20139,716 words Article 1480LAuthor(s): Maryada Sharma 1, Anil Tiwari 1, Shweta Sharma 1, Preeti Bhoria 2, Vishali Gupta 3, Amod Gupta 3, Manni Luthra-Guptasarma 1,* Introduction Persistent stimulus of chronic inflammation, in response to...

• Ebolavirus Nucleoprotein C-Termini Potently Attract Single Domain Antibodies Enabling Monoclonal Affinity Reagent Sandwich Assay (MARSA) Formulation

  Authors:Laura J. Sherwood and Andrew HayhurstFrom:PLoS ONE (Vol. 8, Issue 4) Peer-Reviewed

  Apr. 5, 201312,966 words Article 1800LAuthor(s): Laura J. Sherwood, Andrew Hayhurst * Introduction Viruses are usually experts in energetic economy, employing multiple copies of a relatively small repertoire of key architectural templates to assemble...

• A Selection Fit Mechanism in BMP Receptor IA as a Possible Source for BMP Ligand-Receptor Promiscuity

  Authors:Stefan Harth, Alexander Kotzsch, Junli Hu, Walter Sebald, and Thomas D. MuellerFrom:PLoS ONE (Vol. 5, Issue 9) Peer-Reviewed

  Sept. 28, 20109,528 words Article 1660LBackground Members of the TGF-[beta] superfamily are characterized by a highly promiscuous ligand-receptor interaction as is readily apparent from the numeral discrepancy of only seven type I and five type II...