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Academic Journals
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From:Gene Therapy (Vol. 12, Issue 12) Peer-ReviewedAuthor(s): P E Nielsen [1] Recent successes in effectively delivering new siRNA antisense agents systemically to produce therapeutic outcomes in mice[1, 2] have been extremely impressive, but how close are we to...
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From:PLoS ONE (Vol. 7, Issue 1) Peer-ReviewedAuthor(s): Huei-Mei Chen **b , Adam P. Rosebrock **a , Sohail R. Khan, Bruce Futcher * , Janet K. Leatherwood * Introduction In a simple case of gene expression only the sense DNA strand of a protein-coding region...
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From:PLoS ONE (Vol. 8, Issue 5) Peer-ReviewedAuthor(s): Stephan Wiegand, Christian Hammann * Introduction Double stranded RNA is the central nucleic acid entity in the gene regulatory mechanism RNA interference (RNAi) [1] that acts in many eukaryotes....
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From:Stem Cells InternationalPeer-ReviewedLong noncoding RNAs (lncRNA) have been recognized as important regulators in diverse biological processes, such as transcriptional regulation, stem cell proliferation, and differentiation. Previous study has...
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From:BioMed Research InternationalPeer-ReviewedRecent study shows that long noncoding RNAs (lncRNAs) are participating in diverse biological processes and complex diseases. However, at present the functions of lncRNAs are still rarely known. In this study, we...
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From:BioMed Research International (Vol. 2017) Peer-ReviewedRecent researches have demonstrated that long noncoding RNA linc00152 was aberrantly upregulated in multiple tumor types. High expression of linc00152 was associated with poor outcomes in cancer patients. Therefore, we...
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From:Stem Cell Research & Therapy (Vol. 10, Issue 1) Peer-ReviewedBackground Human naïve pluripotency state cells can be derived from direct isolation of inner cell mass or primed-to-naïve resetting of human embryonic stem cells (hESCs) through different combinations of transcription...
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From:PeerJ (Vol. 8) Peer-ReviewedPurpose Recent studies have determined that long non-coding RNAs (lncRNAs) are potential prognostic biomarkers for non-small cell lung cancers (NSCLCs). The purpose of this study was to analyze the function and...
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From:PLoS ONE (Vol. 10, Issue 8) Peer-ReviewedCCCTC binding factor (CTCF) is involved in organizing chromosomes into mega base-sized, topologically associated domains (TADs) along with other factors that define sub-TAD organization. CTCF-Cohesin interactions have...
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From:PLoS ONE (Vol. 11, Issue 7) Peer-ReviewedGonadotropin-releasing hormone (GnRH), a neuropeptide released from a small population of neurons in the hypothalamus, is the central mediator of the hypothalamic-pituitary-gonadal axis, and is required for normal...
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From:PLoS ONE (Vol. 15, Issue 1) Peer-ReviewedRecent studies have demonstrated the implication of long noncoding RNAs (lncRNAs) in a variety of physiological and pathological processes. However, the majority of lncRNAs are functionally unknown. The current study...
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From:Journal of Experimental & Clinical Cancer Research (Vol. 34, Issue 1) Peer-ReviewedBackground Accumulating evidence suggests the pro-inflammatory cytokine interleukin-6 (IL-6) in tumor microenvironment may promote the development of hepatocellular carcinoma (HCC). However, the underlying mechanism...
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From:Journal of Oncology (Vol. 2022) Peer-ReviewedBackground. Molecular features have been included in the categorization of gliomas because they may be excellent predictors of tumor prognosis. Lower-grade glioma (LGGs, which comprise grade 2 and grade 3 gliomas)...
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From:Journal of Biomolecular Screening (Vol. 12, Issue 6) Peer-ReviewedHigh-content imaging (HCI) provides researchers with a powerful tool for understanding cellular processes. Although phenotypic analysis generated through HCI is a potent technique to determine the overall cellular...
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From:Stem Cell Research & Therapy (Vol. 11, Issue 1) Peer-ReviewedBackground MEG3 downregulated the expression in several tumors and inhibits human tumorigenesis. But so far, the mechanism of MEG3 in tumorigenesis is still unclear. Methods In gene infection, cellular and...
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From:BioMed Research International (Vol. 2018) Peer-ReviewedObjective. To investigate the expression of HOX transcript antisense RNA (HOTAIR) in cardiac tissues and plasma of patients with congenital heart diseases (CHDs). Methods. qRT-PCR was used to detect the expression of...
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From:BioMed Research International (Vol. 2020) Peer-ReviewedThe aim of this study was to explore whether the long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1)/miR-34a/Snail1 and NEAT1/miR-204/Zeb1 pathways are involved in epithelial-mesenchymal transition (EMT)...
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From:Journal of Hematology & Oncology (Vol. 11, Issue 1) Peer-ReviewedEsophageal cancer (EC) is the sixth leading cause of cancer-related death worldwide. The lack of early diagnostic biomarkers and effective prognostic indicators for metastasis and recurrence has resulted in the poor...
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From:Journal of Experimental & Clinical Cancer Research (Vol. 34, Issue 1) Peer-ReviewedBackground Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) has been demonstrated to be an important player in various human malignancies; it is thought to promote tumor growth by cell cycle...
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From:Stem Cells International (Vol. 2022) Peer-ReviewedStem cells from human exfoliated deciduous teeth (SHED) are attractive seed cells for dental tissue engineering. Epigenetics refers to heritable changes in gene expression patterns that do not alter DNA sequences. Long...