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    Academic Journals

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• Tumor-targeting nanosystems for the delivery of siRNA

  Author:Achim AignerFrom:Nanomedicine (Vol. 2, Issue 4) Peer-Reviewed

  Aug. 20072,459 words Article Author(s): Achim Aigner 1 Keywords: HER-2; in vivo; nanoimmunoliposome; RNA interference; siRNA delivery RNA interference (RNAi), although discovered only a few years ago, is already well established for the...

• Systemic delivery: The last hurdle?

  Author:P E NielsenFrom:Gene Therapy (Vol. 12, Issue 12) Peer-Reviewed

  June 20051,545 words Article 1690LAuthor(s): P E Nielsen [1] Recent successes in effectively delivering new siRNA antisense agents systemically to produce therapeutic outcomes in mice[1, 2] have been extremely impressive, but how close are we to...

• Repression of Meiotic Genes by Antisense Transcription and by Fkh2 Transcription Factor in Schizosaccharomyces pombe

  Authors:Huei-Mei Chen, Adam P. Rosebrock, Sohail R. Khan, Bruce Futcher, and Janet K. LeatherwoodFrom:PLoS ONE (Vol. 7, Issue 1) Peer-Reviewed

  Jan. 6, 201212,497 words Article 1400LAuthor(s): Huei-Mei Chen **b , Adam P. Rosebrock **a , Sohail R. Khan, Bruce Futcher * , Janet K. Leatherwood * Introduction In a simple case of gene expression only the sense DNA strand of a protein-coding region...

• The 5' Spreading of Small RNAs in Dictyostelium discoideum Depends on the RNA-Dependent RNA Polymerase RrpC and on the Dicer-Related Nuclease DrnB

  Authors:Stephan Wiegand and Christian HammannFrom:PLoS ONE (Vol. 8, Issue 5) Peer-Reviewed

  May 20, 20136,922 words Article 1560LAuthor(s): Stephan Wiegand, Christian Hammann * Introduction Double stranded RNA is the central nucleic acid entity in the gene regulatory mechanism RNA interference (RNAi) [1] that acts in many eukaryotes....

• The Regulatory Effects of Long Noncoding RNA-ANCR on Dental Tissue-Derived Stem Cells

  Authors:Qian Jia, Xiaolin Chen, Wenkai Jiang, Wei Wang, Bin Guo, and Longxing NiFrom:Stem Cells InternationalPeer-Reviewed

  Annual 20166,084 words Article 1310LLong noncoding RNAs (lncRNA) have been recognized as important regulators in diverse biological processes, such as transcriptional regulation, stem cell proliferation, and differentiation. Previous study has...

• Repertoire of noncoding RNAs in corpus luteum of early pregnancy in buffalo (Bubalus bubalis)

  Authors:A. Jerome, S.M.K. Thirumaran, and S.N. KalaFrom:Veterinary World (Vol. 10, Issue 9)

  Sept. 20173,046 words Article 1390LAim: The present study was designed to identify other noncoding RNAs (ncRNAs) in the corpus luteum (CL) during early pregnancy in buffalo. Materials and Methods: For this study, CL (n=2) from two buffalo gravid...

• Predicting Long Noncoding RNA and Protein Interactions Using Heterogeneous Network Model

  Authors:Ao Li, Mengqu Ge, Yao Zhang, Chen Peng, and Minghui WangFrom:BioMed Research InternationalPeer-Reviewed

  Annual 20165,689 words Article 1430LRecent study shows that long noncoding RNAs (lncRNAs) are participating in diverse biological processes and complex diseases. However, at present the functions of lncRNAs are still rarely known. In this study, we...

• Clinicopathological and Prognostic Role of Long Noncoding RNA Linc00152 in Various Human Neoplasms: Evidence from Meta-Analysis

  Authors:Chenkui Miao, Kai Zhao, Jundong Zhu, Chao Liang, Aiming Xu, Yibo Hua, et al.From:BioMed Research International (Vol. 2017) Peer-Reviewed

  Annual 20174,395 words Report 1360LRecent researches have demonstrated that long noncoding RNA linc00152 was aberrantly upregulated in multiple tumor types. High expression of linc00152 was associated with poor outcomes in cancer patients. Therefore, we...

• Small ncRNA-Seq Results of Human Tissues: Variations Depending on Sample Integrity

  Authors:Nicole Ludwig, Tobias Fehlmann, Valentina Galata, Andre Franke, Christina Backes, Eckart Meese, et al.From:Clinical Chemistry (Vol. 64, Issue 7) Peer-Reviewed

  July 20185,456 words Article 1480LBACKGROUND: Although mature miRNAs are relatively stable in vivo, RNA degradation can have a substantial influence on small noncoding RNA (sncRNA) profiles. METHODS: Using different tissue storage conditions and RNA...

• Long noncoding RNA CCDC144NL-AS1 knockdown induces naïve-like state conversion of human pluripotent stem cells.

  Authors:Yingying Wang, Baosen Guo, Zengrong Xiao, Haijun Lin, Xi Zhang, Yueqiang Song, et al.From:Stem Cell Research & Therapy (Vol. 10, Issue 1) Peer-Reviewed

  July 29, 201911,144 words Report 1530LBackground Human naïve pluripotency state cells can be derived from direct isolation of inner cell mass or primed-to-naïve resetting of human embryonic stem cells (hESCs) through different combinations of transcription...

• HOTAIR Is a Potential Novel Biomarker in Patients with Congenital Heart Diseases.

  Authors:Yu Jiang, Hongdan Mo, Jing Luo, Suhong Zhao, Shuang Liang, Maomao Zhang, et al.From:BioMed Research International (Vol. 2018) Peer-Reviewed

  Annual 20184,136 words Article 1410LObjective. To investigate the expression of HOX transcript antisense RNA (HOTAIR) in cardiac tissues and plasma of patients with congenital heart diseases (CHDs). Methods. qRT-PCR was used to detect the expression of...

• The long-noncoding RNA MALAT1 regulates TGF-[beta]/Smad signaling through formation of a lncRNA-protein complex with Smads, SETD2 and PPM1A in hepatic cells.

  Authors:Jinqiang Zhang, Chang Han, Kyoungsub Song, Weina Chen, Nathan Ungerleider, Lu Yao, et al.From:PLoS ONE (Vol. 15, Issue 1) Peer-Reviewed

  Jan. 29, 20206,394 words Article 1480LRecent studies have demonstrated the implication of long noncoding RNAs (lncRNAs) in a variety of physiological and pathological processes. However, the majority of lncRNAs are functionally unknown. The current study...

• Long Noncoding RNA NEAT1 Regulates TGF-[beta]2-Induced Epithelial-Mesenchymal Transition of Lens Epithelial Cells through the miR-34a/Snail1 and miR-204/Zeb1 Pathways.

  Author:Ning DongFrom:BioMed Research International (Vol. 2020) Peer-Reviewed

  June 30, 20206,587 words Article 1340LThe aim of this study was to explore whether the long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1)/miR-34a/Snail1 and NEAT1/miR-204/Zeb1 pathways are involved in epithelial-mesenchymal transition (EMT)...

• ZFPM2-AS1 promotes the proliferation, migration, and invasion of human non-small cell lung cancer cells involving the JAK-STAT and AKT pathways.

  Authors:Xiwen Wang, Jun Tang, Jungang Zhao, Bin Lou, and Li LiFrom:PeerJ (Vol. 8) Peer-Reviewed

  Oct. 26, 20205,767 words Article 1320LPurpose Recent studies have determined that long non-coding RNAs (lncRNAs) are potential prognostic biomarkers for non-small cell lung cancers (NSCLCs). The purpose of this study was to analyze the function and...

• Long noncoding RNA MEG3 blocks telomerase activity in human liver cancer stem cells epigenetically.

  Authors:Xiaoxue Jiang, Liyan Wang, Sijie Xie, Yingjie Chen, Shuting Song, Yanan Lu, et al.From:Stem Cell Research & Therapy (Vol. 11, Issue 1) Peer-Reviewed

  Nov. 30, 20209,801 words Article 1480LBackground MEG3 downregulated the expression in several tumors and inhibits human tumorigenesis. But so far, the mechanism of MEG3 in tumorigenesis is still unclear. Methods In gene infection, cellular and...

• Long non-coding RNAs in esophageal cancer: molecular mechanisms, functions, and potential applications

  Authors:Min Su, Yuhang Xiao, Junliang Ma, Deliang Cao, Yong Zhou, Hui Wang, et al.From:Journal of Hematology & Oncology (Vol. 11, Issue 1) Peer-Reviewed

  Sept. 17, 20188,588 words Report 1430LEsophageal cancer (EC) is the sixth leading cause of cancer-related death worldwide. The lack of early diagnostic biomarkers and effective prognostic indicators for metastasis and recurrence has resulted in the poor...

• Up-regulation of long noncoding RNA MALAT1 contributes to proliferation and metastasis in esophageal squamous cell carcinoma

  Authors:Liwen Hu, Yuanyuan Wu, Deli Tan, Hui Meng, Kai Wang, Yun Bai, et al.From:Journal of Experimental & Clinical Cancer Research (Vol. 34, Issue 1) Peer-Reviewed

  Jan. 22, 20157,687 words Article 1470LBackground Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) has been demonstrated to be an important player in various human malignancies; it is thought to promote tumor growth by cell cycle...

• Boundary Associated Long Noncoding RNA Mediates Long-Range Chromosomal Interactions

  Authors:Ifeoma Jane Nwigwe, Yoon Jung Kim, David A. Wacker, and Tae Hoon KimFrom:PLoS ONE (Vol. 10, Issue 8) Peer-Reviewed

  Aug. 24, 20157,664 words Report 1360LCCCTC binding factor (CTCF) is involved in organizing chromosomes into mega base-sized, topologically associated domains (TADs) along with other factors that define sub-TAD organization. CTCF-Cohesin interactions have...

• Long noncoding RNA lncTCF7, induced by IL-6/STAT3 transactivation, promotes hepatocellular carcinoma aggressiveness through epithelial-mesenchymal transition

  Authors:Jun Wu, Jun Zhang, Bin Shen, Kai Yin, Jianwei Xu, Wencan Gao, et al.From:Journal of Experimental & Clinical Cancer Research (Vol. 34, Issue 1) Peer-Reviewed

  Oct. 9, 20155,226 words Article 1620LBackground Accumulating evidence suggests the pro-inflammatory cytokine interleukin-6 (IL-6) in tumor microenvironment may promote the development of hepatocellular carcinoma (HCC). However, the underlying mechanism...

• A Novel Gonadotropin-Releasing Hormone 1 (Gnrh1) Enhancer-Derived Noncoding RNA Regulates Gnrh1 Gene Expression in GnRH Neuronal Cell Models

  Authors:Polly P. Huang, Liza E. Brusman, Anita K. Iyer, Nicholas J. G. Webster, and Pamela L. MellonFrom:PLoS ONE (Vol. 11, Issue 7) Peer-Reviewed

  July 7, 201611,529 words Report 1580LGonadotropin-releasing hormone (GnRH), a neuropeptide released from a small population of neurons in the hypothalamus, is the central mediator of the hypothalamic-pituitary-gonadal axis, and is required for normal...