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    Academic Journals

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• Evidence for the essentiality of arachidonic and docosahexaenoic acid in the postnatal maternal and infant diet for the development of the infant's immune system early in life

  Authors:Caroline Richard, Erin D. Lewis, and Catherine J. FieldFrom:Applied Physiology, Nutrition, and Metabolism (Vol. 41, Issue 5) Peer-Reviewed

  May 20169,123 words Report 1700LLong-chain polyunsaturated fatty acids (LCPUFA), especially the balance between arachidonic (AA) and docosahexaenoic (DHA) acids are known to have important immunomodulatory roles during the postnatal period when the...

• Water-soluble compounds in the herbal preparation Abana inhibit lipid biosynthesis and enhance cholesterol efflux in Hep[G.sub.2] cells

  Authors:Satyakumar Vidyashankar, Ashok Godavarthi, R. Sandeep Varma, and Krishna S. NandakumarFrom:Canadian Journal of Physiology and Pharmacology (Vol. 88, Issue 4) Peer-Reviewed

  Apr. 20105,189 words Report Higher concentrations of circulating lipids (cholesterol and triglycerides) and their decreased catabolism pose a major risk in the development of atherosclerosis and coronary heart disease (CHD). Although statins are...

• LRP1 Controls cPLA.sub.2 Phosphorylation, ABCA1 Expression and Cellular Cholesterol Export

  Authors:Li Zhou, Hong Y. Choi, Wei-Ping Li, Fang Xu, and Joachim HerzFrom:PLoS ONE (Vol. 4, Issue 8) Peer-Reviewed

  Aug. 31, 20097,809 words Article 1490LBackground ATP-binding cassette transporter A1 mediates apolipoprotein AI-dependent efflux of cholesterol and thereby removes cholesterol from peripheral tissues. ABCA1 expression is tightly regulated and deficiency...

• Inhibiting Delta-6 Desaturase Activity Suppresses Tumor Growth in Mice

  Authors:Chengwei He, Xiying Qu, Jianbo Wan, Rong Rong, Lili Huang, Chun Cai, et al.From:PLoS ONE (Vol. 7, Issue 10) Peer-Reviewed

  Oct. 24, 20126,942 words Article 1600LRecent studies have shown that a tumor-supportive microenvironment is characterized by high levels of pro-inflammatory and pro-angiogenic eicosanoids derived from omega-6 (n-6) arachidonic acid (AA). Although the...

• Glycerol-3-Phosphate Acyltransferase-2 Is Expressed in Spermatic Germ Cells and Incorporates Arachidonic Acid into Triacylglycerols

  Authors:Elizabeth R. Cattaneo, Magali Pellon-Maison, Martin E. Rabassa, Ezequiel Lacunza, Rosalind A. Coleman, and Maria R. Gonzalez-BaroFrom:PLoS ONE (Vol. 7, Issue 8) Peer-Reviewed

  Aug. 8, 20127,410 words Article 1440LBackground De novo glycerolipid synthesis begins with the acylation of glycerol-3 phosphate catalyzed by glycerol-3-phosphate acyltransferase (GPAT). In mammals, at least four GPAT isoforms have been described,...

• Phytother Res: The effect of fenugreek on the gene expression of arachidonic acid metabolizing enzymes

  Authors:T. Varjas, G. Nowrasteh, and F. BudanFrom:Alternative Medicine Review (Vol. 15, Issue 3) Peer-Reviewed

  Sept. 2010204 words Brief article, Clini... 1180LThe main bioactive compounds of Trigonella foenum graecum L. (fenugreek) seeds are protodioscin, trigoneoside, diosgenin and yamogenin, which have anticarcinogenic potency through inhibition of cell proliferation and...

• Potassium channels in cardiac cells activated by arachidonic acid and phospholipids

  Authors:Donghee Kim and David E. ClaphamFrom:Science (Vol. 244, Issue 4909) Peer-Reviewed

  June 9, 19891,433 words Article Potassium Channels in Cardiac Cells Activated by Arachidonic Acid and Phospholipids MANY K.sup.+ CHANNELS ARE MODULATED by intracellular second messengers. Most regulatory mechanisms described to date have involved...

• A Midgut Digestive Phospholipase [A.sub.2] in Larval Mosquitoes, Aedes albopictus and Culex quinquefasciatus

  Authors:Nor Aliza Abdul Rahim, Marlini Othman, Muna Sabri, and David W. StanleyFrom:Enzyme Research (Vol. 2018) Peer-Reviewed

  Annual 20185,077 words Article 1360LPhospholipase [A.sub.2] ([PLA.sub.2]) is a secretory digestive enzyme that hydrolyzes ester bond at sn-2 position of dietary phospholipids, creating free fatty acid and lysophospholipid. The free fatty acids...

• Eicosanoid Release Is Increased by Membrane Destabilization and CFTR Inhibition in Calu-3 Cells

  Authors:Florence Borot, Diane-Lore Vieu, Grazyna Faure, Janine Fritsch, Julien Colas, Sandra Moriceau, et al.From:PLoS ONE (Vol. 4, Issue 10) Peer-Reviewed

  Oct. 22, 200910,020 words Article 1480LAuthor(s): Florence Borot 1, Diane-Lore Vieu 1, Grazyna Faure 2, Janine Fritsch 1, Julien Colas 1, Sandra Moriceau 1, Maryvonne Baudouin-Legros 1, Franck Brouillard 1, Jesus Ayala-Sanmartin 3, Lhousseine Touqui 4, Marc...

• Differential Expression of Prostaglandin I2 Synthase Associated with Arachidonic Acid Pathway in the Oral Squamous Cell Carcinoma

  Authors:Anelise Russo, Patricia M. Biselli-Chicote, Rosa S. Kawasaki-Oyama, Marcia M.U. Castanhole-Nunes, Jose V. Maniglia, Dalisio de Santi Neto, et al.From:Journal of Oncology (Vol. 2018) Peer-Reviewed

  Annual 20187,965 words Article 1560LIntroduction. Differential expression of genes encoding cytochrome P450 (CYP) and other oxygenases enzymes involved in biotransformation mechanisms of endogenous and exogenous compounds can lead to oral tumor...

• Gallic Acid-L-Leucine Conjugate Protects Mice against LPS-Induced Inflammation and Sepsis via Correcting Proinflammatory Lipid Mediator Profiles and Oxidative Stress.

  Authors:Yuanyuan Cheng, Xuechen Li, Hung-Fat Tse, and Jianhui RongFrom:Oxidative Medicine and Cellular Longevity (Vol. 2018) Peer-Reviewed

  Annual 20187,946 words Article 1420LThe pathology of endotoxin LPS-induced sepsis is hallmarked by aberrant production of proinflammatory lipid mediators and nitric oxide (NO). The aim of the present study was to determine whether the new product gallic...

• Attenuation of Thrombosis by Crude Rice (Oryza sativa) Bran Policosanol Extract: Ex Vivo Platelet Aggregation and Serum Levels of Arachidonic Acid Metabolites.

  Authors:Wai-Teng Wong, Maznah Ismail, Eusni Rahayu Mohd TohiRasedee Abdullah, and Yi-Da ZhangFrom:Evidence - Based Complementary and Alternative MedicinePeer-Reviewed

  Annual 20164,580 words Article 1370LBackground. Vascular occlusion or thrombosis was often attributed to uncontrolled platelet activation. Influence of sugarcane policosanol extract on platelet was reported but little was known of rice bran policosanol,...

• Differential Cerebral Cortex Transcriptomes of Baboon Neonates Consuming Moderate and High Docosahexaenoic Acid Formulas

  Authors:Kumar S.D. Kothapalli, Joshua C. Anthony, Bruce S. Pan, Andrea T. Hsieh, Peter W. Nathanielsz, and J. Thomas BrennaFrom:PLoS ONE (Vol. 2, Issue 4) Peer-Reviewed

  Apr. 11, 200713,249 words Article 1380LBackground Docosahexaenoic acid (DHA, 22:6n-3) and arachidonic acid (ARA, 20:4n-6) are the major long chain polyunsaturated fatty acids (LCPUFA) of the central nervous system (CNS). These nutrients are present in...

• Arachidonic Acid Randomizes Endothelial Cell Motion and Regulates Adhesion and Migration

  Authors:Ninna Struck Rossen, Anker Jon Hansen, Christine Selhuber-Unkel, and Lene Broeng OddershedeFrom:PLoS ONE (Vol. 6, Issue 9) Peer-Reviewed

  Sept. 23, 20116,939 words Article 1440LCell adhesion and migration are essential for the evolution, organization, and repair of living organisms. An example of a combination of these processes is the formation of new blood vessels (angiogenesis), which is...

• Monoacylglycerol Lipase Regulates Fever Response

  Authors:Manuel Sanchez-Alavez, William Nguyen, Simone Mori, Gianluca Moroncini, Andreu Viader, Daniel K. Nomura, et al.From:PLoS ONE (Vol. 10, Issue 8) Peer-Reviewed

  Aug. 19, 20154,046 words Article 1600LCyclooxygenase inhibitors such as ibuprofen have been used for decades to control fever through reducing the levels of the pyrogenic lipid transmitter prostaglandin E2 (PGE.sub.2). Historically, phospholipases have been...

• Drug-drug-gene interactions as mediators of adverse drug reactions to diclofenac and statins: a case report and literature review/Interakcije lijek-lijek-gen kao posrednici nuspojava diklofenaka i statina--prikaz slucaja i pregled literature.

  Authors:Nada Bozina, Lana Ganoci, Livija Simicevic, Katarina Gvozdanovic, Iva Klarica Domjanovic, Margareta Fistrek Prlic, et al.From:Archives of Industrial Hygiene and Toxicology (Vol. 72, Issue 2) Peer-Reviewed

  June 20218,988 words Article 1510LConcomitant treatment with drugs that inhibit drug metabolising enzymes and/or transporters, such as commonly prescribed statins and nonsteroidal anti-inflammatory drugs (NSAIDs), has been associated with prolonged drug...

• Differential regulation of protein expression in response to polyunsaturated fatty acids in the liver of apoE-knockout mice and in HepG2 cells

  Authors:Chun-Ying Huang, Wei-Ming Chen, Yeou-Guang Tsay, Shu-Chen Hsieh, Yun Lin, Wen-Jane Lee, et al.From:Journal of Biomedical Science (Vol. 22, Issue 1) Peer-Reviewed

  Feb. 7, 20157,508 words Article 1480LBackground Polyunsaturated fatty acids (PUFAs) are nutrients necessary for life. The liver is the essential metabolic center, which aids in maintaining health via diverse biological actions. In the present work, a...

• Arachidonic acid drives adaptive responses to chemotherapy-induced stress in malignant mesothelioma.

  Authors:Mario Cioce, Claudia Canino, Harvey Pass, Giovanni Blandino, Sabrina Strano, and Vito Michele FazioFrom:Journal of Experimental & Clinical Cancer Research (Vol. 40, Issue 1) Peer-Reviewed

  Nov. 2, 20218,930 words Report 1470LAbstract Background High resistance to therapy and poor prognosis characterizes malignant pleural mesothelioma (MPM). In fact, the current lines of treatment, based on platinum and pemetrexed, have limited impact on...

• The effect of supplementation of docosahexaenoic acid and arachidonic acid on visual acuity and neurodevelopment in larger preterm infants

  Authors:P.C. Fang, H.K. Kuo, and C.B. HuangFrom:Alternative Medicine Review (Vol. 11, Issue 1) Peer-Reviewed

  Mar. 2006264 words Brief article 1310LBACKGROUND: Preterm infants may be born with deficits of both docosahexaenoic acid (DHA) and arachidonic acid (AA), but studies on supplementation of DHA and AA for preterm infants are limited. METHODS: Preterm infants...

• Relation between arachidonic acid and docosahexaenoic acid in maternal and neonatal blood

  Authors:P. Rump and G. HornstraFrom:European Journal of Clinical Nutrition (Vol. 55, Issue 10) Peer-Reviewed

  Oct. 2001803 words Clinical report 1490LRecently, Ghebremeskel and colleagues reported in this journal on the relations found between arachidonic acid (AA) and docosahexaenoic acid (DHA) concentrations in various blood lipid fractions of pregnant women and...