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    Academic Journals

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• Neuropathic pain in cancer patients: A brief review

  Authors:V. Loomba, H. Kaveeshvar, A. Upadhyay, and N. SibaiFrom:Indian Journal of Cancer (Vol. 52, Issue 3) Peer-Reviewed

  July-September 20153,358 words Article 1740LByline: V. Loomba, H. Kaveeshvar, A. Upadhyay, N. Sibai Neuropathic pain (NP) is initiated or caused by a primary lesion or dysfunction in the nervous system. The NP in cancer patients is typically due to a...

• Selective Cholinergic Depletion in Medial Septum Leads to Impaired Long Term Potentiation and Glutamatergic Synaptic Currents in the Hippocampus

  Authors:Patrick M. Kanju, Kodeeswaran Parameshwaran, Catrina Sims-Robinson, Subramaniam Uthayathas, Eleanor M. Josephson, Nagalingam Rajakumar, et al.From:PLoS ONE (Vol. 7, Issue 2) Peer-Reviewed

  Feb. 15, 20128,418 words Article 1460LAuthor(s): Patrick M. Kanju 1 , 2 , Kodeeswaran Parameshwaran 1 , 3 , Catrina Sims-Robinson 1 , 4 , Subramaniam Uthayathas 1 , 5 , Eleanor M. Josephson 6 , Nagalingam Rajakumar 7 , Muralikrishnan Dhanasekaran 1 , Vishnu...

• Erythropoietin Protects Adult Retinal Ganglion Cells against NMDA-, Trophic Factor Withdrawal-, and TNF-[alpha]-Induced Damage

  Authors:Zhi-Yang Chang, Ming-Kung Yeh, Chiao-Hsi Chiang, Yi-Hao Chen, and Da-Wen LuFrom:PLoS ONE (Vol. 8, Issue 1) Peer-Reviewed

  Jan. 30, 20138,105 words Article 1180LPurpose This study aimed to evaluate the neuroprotective effect of EPO in the presence of N-methyl-d-aspartate (NMDA)-, trophic factor withdrawal (TFW)-, and tumor necrosis factor-alpha (TNF-[alpha])-induced toxicity...

• Glutathione Restores the Mechanism of Synaptic Plasticity in Aged Mice to That of the Adult

  Authors:Julie M. Robillard, Grant R. Gordon, Hyun B. Choi, Brian R. Christie, and Brian A. MacVicarFrom:PLoS ONE (Vol. 6, Issue 5) Peer-Reviewed

  May 31, 20115,316 words Article 1410LGlutathione (GSH), the major endogenous antioxidant produced by cells, can modulate the activity of N-methyl-D-aspartate receptors (NMDARs) through its reducing functions. During aging, an increase in oxidative stress...

• Somatostatin Receptor 1 and 5 Double Knockout Mice Mimic Neurochemical Changes of Huntington's Disease Transgenic Mice

  Authors:Padmesh S. Rajput, Geetanjali Kharmate, Michael Norman, Shi-He Liu, Bhagavatula R. Sastry, Charles F. Brunicardi, et al.From:PLoS ONE (Vol. 6, Issue 9) Peer-Reviewed

  Sept. 2, 20118,632 words Article 1460LBackground Selective degeneration of medium spiny neurons and preservation of medium sized aspiny interneurons in striatum has been implicated in excitotoxicity and pathophysiology of Huntington's disease (HD)....

• Right Isomerism of the Brain in Inversus Viscerum Mutant Mice

  Authors:Ryosuke Kawakami, Alice Dobi, Ryuichi Shigemoto, and Isao ItoFrom:PLoS ONE (Vol. 3, Issue 4) Peer-Reviewed

  Apr. 16, 20084,742 words Article 1340LLeft-right (L-R) asymmetry is a fundamental feature of higher-order neural function. However, the molecular basis of brain asymmetry remains unclear. We recently reported L-R asymmetry of hippocampal circuitry caused by...

• Glutamatergic Dysbalance and Oxidative Stress in In Vivo and In Vitro Models of Psychosis Based on Chronic NMDA Receptor Antagonism

  Authors:Just Genius, Johanna Geiger, Anna-Lena Dolzer, Jens Benninghoff, Ina Giegling, Annette M. Hartmann, et al.From:PLoS ONE (Vol. 8, Issue 7) Peer-Reviewed

  July 15, 20136,523 words Article 1520LBackground The psychotomimetic effects of N-methyl-D-aspartate (NMDA) receptor antagonists in healthy humans and their tendency to aggravate psychotic symptoms in schizophrenic patients have promoted the notion of...

• Simulations of symptomatic treatments for Alzheimer's disease: computational analysis of pathology and mechanisms of drug action

  Authors:Patrick D Roberts, Athan Spiros, and Hugo GeertsFrom:Alzheimer's Research & Therapy (Vol. 4, Issue 6) Peer-Reviewed

  Nov. 26, 201213,590 words Report 1590LIntroduction A substantial number of therapeutic drugs for Alzheimer's disease (AD) have failed in late-stage trials, highlighting the translational disconnect with pathology-based animal models. Methods To...

• Delay-dependent impairment of spatial working memory with inhibition of NR2B-containing NMDA receptors in hippocampal CA1 region of rats

  Authors:Xue-Han Zhang, Shu-Su Liu, Feng Yi, Min Zhuo, and Bao-Ming LiFrom:Molecular Brain (Vol. 6, Issue 1) Peer-Reviewed

  Mar. 13, 20136,328 words Article 1410LHippocampal N-methyl-D-aspartate receptor (NMDAR) is required for spatial working memory. Although evidence from genetic manipulation mice suggests an important role of hippocampal NMDAR NR2B subunits (NR2B-NMDARs) in...

• Efficacy of adding magnesium sulfate to bupivacaine for ilioinguinal and iliohypogastric nerve block in acute postherniorrhaphy pain.

  Authors:Maha Abo-Zeid and Mahmoud El MansyFrom:Research and Opinion in Anesthesia and Intensive Care (Vol. 7, Issue 2) Peer-Reviewed

  April-June 20202,873 words Article 1430LByline: Maha. Abo-Zeid, Mahmoud. El Mansy Background Regional block of ilioinguinal and iliohypogastric (IIIH) nerves has been applied to provide postoperative analgesia after inguinal hernia repair. Magnesium sulfate...

• Memantine in the treatment of Alzheimer's disease

  Authors:Anton P Porsteinsson and Kelly M CosmanFrom:Aging Health (Vol. 2, Issue 6) Peer-Reviewed

  Dec. 20068,656 words Drug overview 1430LAuthor(s): Anton P Porsteinsson [[dagger]] 1 , Kelly M Cosman 1 2 Keywords : Alzheimer's disease; dementia; glutamate; memantine; N-methyl-D-aspartate Alzheimer's disease (AD) is a growing public health...

• Diacylglycerol Kinase [beta] Knockout Mice Exhibit Attention-Deficit Behavior and an Abnormal Response on Methylphenidate-Induced Hyperactivity

  Authors:Mitsue Ishisaka, Kenichi Kakefuda, Atsushi Oyagi, Yoko Ono, Kazuhiro Tsuruma, Masamitsu Shimazawa, et al.From:PLoS ONE (Vol. 7, Issue 5) Peer-Reviewed

  May 10, 20126,622 words Article 1270LAuthor(s): Mitsue Ishisaka 1 , Kenichi Kakefuda 1 , Atsushi Oyagi 1 , Yoko Ono 1 , Kazuhiro Tsuruma 1 , Masamitsu Shimazawa 1 , Kiyoyuki Kitaichi 2 , Hideaki Hara 1 , * Introduction Stimulation of cell surface Gq...

• Conantokin-G Attenuates Detrimental Effects of NMDAR Hyperactivity in an Ischemic Rat Model of Stroke

  Authors:Rashna Balsara, Alexander Dang, Deborah L. Donahue, Tiffany Snow, and Francis J. CastellinoFrom:PLoS ONE (Vol. 10, Issue 3) Peer-Reviewed

  Mar. 30, 20158,868 words Article 1520LThe neuroprotective activity of conantokin-G (con-G), a naturally occurring antagonist of N-methyl-D-aspartate receptors (NMDAR), was neurologically and histologically compared in the core and peri-infarct regions after...

• Conserved Expression of the Glutamate NMDA Receptor 1 Subunit Splice Variants during the Development of the Siberian Hamster Suprachiasmatic Nucleus

  Authors:Giles E. Duffield, Jens D. Mikkelsen, and Francis J. P. EblingFrom:PLoS ONE (Vol. 7, Issue 5) Peer-Reviewed

  May 31, 201210,127 words Article 1490LGlutamate neurotransmission and the N-methyl-D-aspartate receptor (NMDAR) are central to photic signaling to the master circadian pacemaker located in the hypothalamic suprachiasmatic nucleus (SCN). NMDARs also play...

• A Novel High-Content Flow Cytometric Method for Assessing the Viability and Damage of Rat Retinal Ganglion Cells

  Authors:Zhi-Yang Chang, Da-Wen Lu, Ming-Kung Yeh, and Chiao-Hsi ChiangFrom:PLoS ONE (Vol. 7, Issue 3) Peer-Reviewed

  Mar. 23, 20127,287 words Article 1400LPurpose The aim of the study was to develop a high-content flow cytometric method for assessing the viability and damage of small, medium, and large retinal ganglion cells (RGCs) in N-methyl-D-aspartic acid...

• Sleep-Deprivation Induces Changes in GABA.sub.B and mGlu Receptor Expression and Has Consequences for Synaptic Long-Term Depression

  Authors:Ramakrishna Tadavarty, Padmesh S. Rajput, Jennifer M. Wong, Ujendra Kumar, and Bhagavatula R. SastryFrom:PLoS ONE (Vol. 6, Issue 9) Peer-Reviewed

  Sept. 27, 20119,510 words Article 1420LLong term depression (LTD) in the CA1 region of the hippocampus, induced with a 20-Hz, 30 s tetanus to Schaffer collaterals, is enhanced in sleep-deprived (SD) rats. In the present study, we investigated the role of...

• Soluble epoxide hydrolase inhibitor enhances synaptic neurotransmission and plasticity in mouse prefrontal cortex

  Authors:Han-Fang Wu, Hsin-Ju Yen, Chi-Chen Huang, Yi-Chao Lee, Su-Zhen Wu, Tzong-Shyuan Lee, et al.From:Journal of Biomedical Science (Vol. 22, Issue 1) Peer-Reviewed

  Oct. 22, 20157,439 words Article 1490LBackground The soluble epoxide hydrolase (sEH) is an important enzyme chiefly involved in the metabolism of fatty acid signaling molecules termed epoxyeicosatrienoic acids (EETs). sEH inhibition (sEHI) has proven to...

• Potentiation of NMDA Receptor-Dependent Cell Responses by Extracellular High Mobility Group Box 1 Protein

  Authors:Marco Pedrazzi, Monica Averna, Bianca Sparatore, Mauro Patrone, Franca Salamino, Manuela Marcoli, et al.From:PLoS ONE (Vol. 7, Issue 8) Peer-Reviewed

  Aug. 31, 20128,172 words Article 1450LAuthor(s): Marco Pedrazzi 1 , 2 , Monica Averna 1 , 2 , * , Bianca Sparatore 1 , 2 , Mauro Patrone 3 , Franca Salamino 1 , 2 , Manuela Marcoli 1 , 2 , Guido Maura 1 , 2 , Chiara Cervetto 1 , Daniela Frattaroli 1 ,...

• Effect of Multimeric Structure of CaMKII in the GluN2B-Mediated Modulation of Kinetic Parameters of ATP

  Authors:John Cheriyan, Archana G. Mohanan, Pradeep K. Kurup, Madhavan Mayadevi, and Ramakrishnapillai Vyomakesannair OmkumarFrom:PLoS ONE (Vol. 7, Issue 9) Peer-Reviewed

  Sept. 18, 20124,995 words Article 1390LAuthor(s): John Cheriyan, Archana G. Mohanan, Pradeep K. Kurup, Madhavan Mayadevi, Ramakrishnapillai Vyomakesannair Omkumar * Introduction Calcium/calmodulin dependent protein kinase II (CaMKII) is a kinase of...

• Clinical trials of new drugs for Alzheimer disease.

  Authors:Li-Kai Huang, Shu-Ping Chao, and Chaur-Jong HuFrom:Journal of Biomedical Science (Vol. 27, Issue 1) Peer-Reviewed

  Jan. 6, 20206,353 words Article 1440LAlzheimer disease (AD) accounts for 60-70% of dementia cases. Given the seriousness of the disease and continual increase in patient numbers, developing effective therapies to treat AD has become urgent. Presently, the...