Search Results

• • 3,287 

    Academic Journals

  • Sort by: sorttype.publication.date.desc Newest sorttype.publication.date.asc Oldest sorttype.relevance Relevance

• From optimized monovalent ligands to size-controlled dendrimers: an efficient strategy towards high-activity DC-SIGN antagonists

  Authors:Stefania Ordanini, Giulio Goti, and Anna BernardiFrom:Canadian Journal of Chemistry (Vol. 95, Issue 9) Peer-Reviewed

  Sept. 20175,378 words Report 1750LAbstract: This short review describes our work on the development of dendrimeric antagonists of DC-SIGN, a dendritic cells (DCs) receptor recognizing highly mannosylated structures and primarily involved in the...

• Structural basis of species-selective antagonist binding to the succinate receptor

  Authors:Matthias Haffke, Dominique Fehlmann, Gabriele Rummel, Jacques Boivineau, Myriam Duckely, Nina Gommermann, et al.From:Nature (Vol. 574, Issue 7779) Peer-Reviewed

  Oct. 20199,702 words Report 1540LThe tricarboxylic acid cycle intermediate succinate is involved in metabolic processes and plays a crucial role in the homeostasis of mitochondrial reactive oxygen species.sup.1. The receptor responsible for succinate...

• Solution structure of the SH3 domain of Src and identification of its ligand-binding site

  Authors:Hongtao Yu, Michael K. Rosen, Tae Bum Shin, Cynthia Seidel-Dugan, Joan S. Brugge, and Stuart L. SchreiberFrom:Science (Vol. 258, Issue 5088) Peer-Reviewed

  Dec. 4, 19922,367 words Article The Src homology 3 (SH3) region is a protein domain of 55 to 75 amino acids found in many cytoplasmic proteins, including those that participate in signal transduction pathways. The solution structure of the SH3 domain...

• Structure of the nucleotide activation switch in glycogen phosphorylase a

  Authors:Stephen Sprang, Elizabeth Goldsmith, and Robert FletterickFrom:Science (Vol. 237) Peer-Reviewed

  Aug. 28, 19875,222 words Article Structure of the Nucleotide Activation Switch in Glycogen Phosphorylase a GLYCOGEN PHOSPHORYLASE (GP) MOBILIZES GLUCOSE-1-phosphate (G1P) in eukaryotes and is regulated by two parallel mechanisms. The primary control,...

• Design of functional metalloproteins

  Authors:Yi Lu, Natasha Yeung, Nathan Sieracki, and Nicholas M. MarshallFrom:Nature (Vol. 460, Issue 7257) Peer-Reviewed

  Aug. 13, 20098,155 words Report 1500LMetalloproteins catalyse some of the most complex and important processes in nature, such as photosynthesis and water oxidation. An ultimate test of our knowledge of how metalloproteins work is to design new...

• Structure and functional investigation of ligand binding by a family 35 carbohydrate binding module (CtCBM35) of [beta]-mannanase of family 26 glycoside hydrolase from Clostridium thermocellum

  Authors:A. Ghosh, A.K. Verma, S. Gautam, M.N. Gupta, and A. GoyalFrom:Biochemistry (Moscow) (Vol. 79, Issue 7) Peer-Reviewed

  July 20146,567 words Report 1490LFunctional attributes of recombinant CtCBM35 (family 35 carbohydrate binding module) of [beta]-mannanase of family 26 Glycoside Hydrolase from Clostridium thermocellum were deduced by biochemical and in silico...

• Competitive agonists and antagonists of steroid nuclear receptors: evolution of the concept or its reversal

  Author:O.V. SmirnovaFrom:Biochemistry (Moscow) (Vol. 80, Issue 10) Peer-Reviewed

  Oct. 20156,650 words Report 1630LThe mechanisms displaying pure and mixed steroid agonist/antagonist activity as well as principles underlying in vivo action of selective steroid receptor modulators dependent on tissue or cell type including...

• A liquid chromatography/mass spectrometry-based method for the selection of ATP competitive kinase inhibitors

  Authors:Sanjay S. Khandekar, Bingbing Feng, Tracey Yi, Susan Chen, Nicholas Laping, and Neal BramsonFrom:Journal of Biomolecular Screening (Vol. 10, Issue 5) Peer-Reviewed

  Aug. 20053,919 words Article The currently approved kinase inhibitors for therapeutic uses and a number of kinase inhibitors that are undergoing clinical trials are directed toward the adenosine triphosphate (ATP) binding site of protein kinases....

• Regulation of Contraction in Striated Muscle

  Authors:A. M. GORDON, E. HOMSHER, and M. REGNIERFrom:Physiological Reviews (Vol. 80, Issue 2) Peer-Reviewed

  Apr. 200065,869 words Article Gordon, A. M., E. Homsher, and M. Regnier. Regulation of Contraction in Striated Muscle. Physiol. Rev. 80: 853-924, 2000--[Ca.sup.2+] regulation of contraction in vertebrate striated muscle is exerted primarily through...

• Taming of a poison: biosynthesis of the NiFe-Hydrogenase cyanide ligands. (Reports)

  Authors:Stefanie Reissmann, Elisabeth Hochleitner, Haofan Wang, Athanasios Paschos, Friedrich Lottspeich, Richard S. Glass, et al.From:Science (Vol. 299, Issue 5609) Peer-Reviewed

  Feb. 14, 20032,244 words Article NiFe-hydrogenases have an Ni-Fe site in which the iron has one CO and two CN groups as ligands. Synthesis of the CN ligands requires the activity of two hydrogenase maturation proteins: HypF and HypE. HypF is a...

• QSAR Study of flavonoids as platelet-activating factor (PAF) receptor binding antagonists

  Authors:N.H. Abdullah, L.S. Kiong, and I.A. NoorbatchaFrom:Advances in Environmental BiologyPeer-Reviewed

  Mar. 20142,174 words Report 1550LFlavonoids are natural inhibitors against platelet activating factor (PAF) receptor. PAF is involved in several patho-physiological conditions such as inflammation, atherosclerosis, asthma and thrombosis. The PAF...

• Exploration of the sea urchin coelomit fluid via combinatorial peptide ligand libraries

  Authors:Elisa Fasoli, Alfonsina D'Amato, Pier Giorgio Righetti, Rainer Barbieri, and Daniele BellavialFrom:The Biological Bulletin (Vol. 222, Issue 2) Peer-Reviewed

  Apr. 20124,221 words Report 1380LThe urchin Paracentrotus lividus has been characterized via previous capture and enhancement of low-abundance proteins with combinatorial peptide ligand libraries (CPLL, ProteoMiner). Whereas in the control only 26...

• Unready for action: boy scouts recognize that the key to success is to be prepared. The same is true of molecules that bind to and open ion channels--the least effective ones are slower to prepare the channel to be ready for opening

  Author:Joe Henry SteinbachFrom:Nature (Vol. 454, Issue 7205) Peer-Reviewed

  Aug. 7, 20081,022 words Report 1370LSome drugs, known collectively as agonists, can be thought of as molecular switches--if the molecule fits the active site of the receptor, the biological response is switched on. But so-called partial agonists pose a...

• Synthesis of a site-specific DNA-binding peptide

  Authors:Michael F. Bruist, Suzanna J. Horvath, Leroy E. Hood, Thomas A. Steitz, and Melvin I. SimonFrom:Science (Vol. 235) Peer-Reviewed

  Feb. 13, 19873,198 words Article Synthesis of a Site-Specific DNA-Binding Peptide MANY SEQUENCE-SPECIFIC DNA-bindingproteins have been found to consist of two distinct structural and functional domains. One domain is responsible for recognizing and...

• A flexible multidose GnRH antagonist versus a microdose flare-up GnRH agonist combined with a flexible multidose GnRH antagonist protocol in poor responders to IVF

  Authors:Gayem Inayet Turgay Celik, Havva Komur Sutcu, Yasam Kemal Akpak, and Munire Erman AkarFrom:BioMed Research InternationalPeer-Reviewed

  Annual 20154,322 words Report 1380LObjective. To compare the effectiveness of a flexible multidose gonadotropin-releasing hormone (GnRH) antagonist against the effectiveness of a microdose flare-up GnRH agonist combined with a flexible multidose GnRH...

• Unusual coordination behaviour of the ferrocenyl-terpyridine ligand with group 11 complexes

  Authors:Javier E. Aguado, M. Concepcion Gimeno, Peter G. Jones, and Antonio LagunaFrom:Canadian Journal of Chemistry (Vol. 87, Issue 1) Peer-Reviewed

  Jan. 20094,310 words Report Complexes of the ligand Fcterpy (Fcterpy = 4'-ferrocenyl-2,2':6',2'-terpyridine) with group 11 metals display different coordination modes. The reaction with complexes [Cu(N[O.sub.3])[(P[Ph.sub.3]).sub.2]] or...

• Potential metal-binding domains in nucleic acid binding proteins

  Author:Jeremy M. BergFrom:Science (Vol. 232) Peer-Reviewed

  Apr. 25, 19861,322 words Article Potential Metal-Binding Domains in Nucleic Acid Binding Proteins CHARACTERIZING THE MECHANISMS by which proteins bind to nucleic acids is of fundamental importance to understanding the processes of gene expression and...

• Amino acids in nine ligand-prefer ramachandran regions

  Authors:Chen Cao, Lincong Wang, Xiaoyang Chen, Shuxue Zou, Guishen Wang, and Shutan XuFrom:BioMed Research InternationalPeer-Reviewed

  Annual 20155,374 words Report 1500LSeveral secondary structures, such as [pi]-helix and left-handed helix, have been frequently identified at protein ligand-binding sites. A secondary structure is considered to be constrained to a specific region of...

• Comparisons of GnRH antagonist protocol versus GnRH agonist long protocol in patients with normal ovarian reserve: A systematic review and meta-analysis

  Authors:Ruolin Wang, Shouren Lin, Yong Wang, Weiping Qian, and Liang ZhouFrom:PLoS ONE (Vol. 12, Issue 4) Peer-Reviewed

  Apr. 24, 20176,070 words Report 1450LObjective To evaluate the effectiveness and safety of gonadotropin-releasing hormone antagonist (GnRH-ant) protocol and gonadotropin-releasing hormone agonist (GnRH-a) long protocol in patients with normal ovarian...

• Design of amidobenzimidazole STING receptor agonists with systemic activity

  Authors:Joshi M. Ramanjulu, G. Scott Pesiridis, Jingsong Yang, Nestor Concha, Robert Singhaus, Shu-Yun Zhang, et al.From:Nature (Vol. 564, Issue 7736) Peer-Reviewed

  Dec. 20184,550 words Technical report 1670LStimulator of interferon genes (STING) is a receptor in the endoplasmic reticulum that propagates innate immune sensing of cytosolic pathogen-derived and self DNA.sup.1. The development of compounds that modulate STING...