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Academic Journals
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From:Canadian Journal of Chemistry (Vol. 95, Issue 9) Peer-ReviewedAbstract: This short review describes our work on the development of dendrimeric antagonists of DC-SIGN, a dendritic cells (DCs) receptor recognizing highly mannosylated structures and primarily involved in the...
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From:Nature (Vol. 574, Issue 7779) Peer-ReviewedThe tricarboxylic acid cycle intermediate succinate is involved in metabolic processes and plays a crucial role in the homeostasis of mitochondrial reactive oxygen species.sup.1. The receptor responsible for succinate...
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From:Science (Vol. 258, Issue 5088) Peer-ReviewedThe Src homology 3 (SH3) region is a protein domain of 55 to 75 amino acids found in many cytoplasmic proteins, including those that participate in signal transduction pathways. The solution structure of the SH3 domain...
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From:Science (Vol. 237) Peer-ReviewedStructure of the Nucleotide Activation Switch in Glycogen Phosphorylase a GLYCOGEN PHOSPHORYLASE (GP) MOBILIZES GLUCOSE-1-phosphate (G1P) in eukaryotes and is regulated by two parallel mechanisms. The primary control,...
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From:Nature (Vol. 460, Issue 7257) Peer-ReviewedMetalloproteins catalyse some of the most complex and important processes in nature, such as photosynthesis and water oxidation. An ultimate test of our knowledge of how metalloproteins work is to design new...
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From:Biochemistry (Moscow) (Vol. 79, Issue 7) Peer-ReviewedFunctional attributes of recombinant CtCBM35 (family 35 carbohydrate binding module) of [beta]-mannanase of family 26 Glycoside Hydrolase from Clostridium thermocellum were deduced by biochemical and in silico...
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From:Biochemistry (Moscow) (Vol. 80, Issue 10) Peer-ReviewedThe mechanisms displaying pure and mixed steroid agonist/antagonist activity as well as principles underlying in vivo action of selective steroid receptor modulators dependent on tissue or cell type including...
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From:Journal of Biomolecular Screening (Vol. 10, Issue 5) Peer-ReviewedThe currently approved kinase inhibitors for therapeutic uses and a number of kinase inhibitors that are undergoing clinical trials are directed toward the adenosine triphosphate (ATP) binding site of protein kinases....
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From:Physiological Reviews (Vol. 80, Issue 2) Peer-ReviewedGordon, A. M., E. Homsher, and M. Regnier. Regulation of Contraction in Striated Muscle. Physiol. Rev. 80: 853-924, 2000--[Ca.sup.2+] regulation of contraction in vertebrate striated muscle is exerted primarily through...
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From:Science (Vol. 299, Issue 5609) Peer-ReviewedNiFe-hydrogenases have an Ni-Fe site in which the iron has one CO and two CN groups as ligands. Synthesis of the CN ligands requires the activity of two hydrogenase maturation proteins: HypF and HypE. HypF is a...
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From:Advances in Environmental BiologyPeer-ReviewedFlavonoids are natural inhibitors against platelet activating factor (PAF) receptor. PAF is involved in several patho-physiological conditions such as inflammation, atherosclerosis, asthma and thrombosis. The PAF...
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From:The Biological Bulletin (Vol. 222, Issue 2) Peer-ReviewedThe urchin Paracentrotus lividus has been characterized via previous capture and enhancement of low-abundance proteins with combinatorial peptide ligand libraries (CPLL, ProteoMiner). Whereas in the control only 26...
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From:Nature (Vol. 454, Issue 7205) Peer-ReviewedSome drugs, known collectively as agonists, can be thought of as molecular switches--if the molecule fits the active site of the receptor, the biological response is switched on. But so-called partial agonists pose a...
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From:Science (Vol. 235) Peer-ReviewedSynthesis of a Site-Specific DNA-Binding Peptide MANY SEQUENCE-SPECIFIC DNA-bindingproteins have been found to consist of two distinct structural and functional domains. One domain is responsible for recognizing and...
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From:BioMed Research InternationalPeer-ReviewedObjective. To compare the effectiveness of a flexible multidose gonadotropin-releasing hormone (GnRH) antagonist against the effectiveness of a microdose flare-up GnRH agonist combined with a flexible multidose GnRH...
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From:Canadian Journal of Chemistry (Vol. 87, Issue 1) Peer-ReviewedComplexes of the ligand Fcterpy (Fcterpy = 4'-ferrocenyl-2,2':6',2'-terpyridine) with group 11 metals display different coordination modes. The reaction with complexes [Cu(N[O.sub.3])[(P[Ph.sub.3]).sub.2]] or...
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From:Science (Vol. 232) Peer-ReviewedPotential Metal-Binding Domains in Nucleic Acid Binding Proteins CHARACTERIZING THE MECHANISMS by which proteins bind to nucleic acids is of fundamental importance to understanding the processes of gene expression and...
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From:BioMed Research InternationalPeer-ReviewedSeveral secondary structures, such as [pi]-helix and left-handed helix, have been frequently identified at protein ligand-binding sites. A secondary structure is considered to be constrained to a specific region of...
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From:PLoS ONE (Vol. 12, Issue 4) Peer-ReviewedObjective To evaluate the effectiveness and safety of gonadotropin-releasing hormone antagonist (GnRH-ant) protocol and gonadotropin-releasing hormone agonist (GnRH-a) long protocol in patients with normal ovarian...
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From:Nature (Vol. 564, Issue 7736) Peer-ReviewedStimulator of interferon genes (STING) is a receptor in the endoplasmic reticulum that propagates innate immune sensing of cytosolic pathogen-derived and self DNA.sup.1. The development of compounds that modulate STING...