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    Academic Journals

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• Lysosomal Pathways and Autophagy Distinctively Control Endothelial Cell Behavior to Affect Tumor Vasculature

  Authors:Marco B. Schaaf, Diede Houbaert, Odeta Mece, San Kit To, Maarten Ganne, Hannelore Maes, et al.From:Frontiers in OncologyPeer-Reviewed

  Mar. 20, 2019385 words Report 1620LAuthor(s): Marco B. Schaaf, Diede Houbaert, Odeta Meçe, San Kit To, Maarten Ganne, Hannelore Maes, Patrizia Agostinis Cancer cell-stromal cell crosstalk is orchestrated by a plethora of ligand-receptor interactions...

• The wavelet power spectrum of perfusion weighted MRI correlates with tumor vascularity in biopsy-proven glioblastoma samples.

  Authors:Lukas T. Rotkopf, Benedikt Wiestler, Christine Preibisch, Friederike Liesche-Starnecker, Thomas Pyka, Dominik Nörenberg, et al.From:PLoS ONE (Vol. 15, Issue 1) Peer-Reviewed

  Jan. 23, 20205,114 words Article 1470LBackground Wavelet transformed reconstructions of dynamic susceptibility contrast (DSC) MR perfusion (wavelet-MRP) are a new and elegant way of visualizing vascularization. Wavelet-MRP maps yield a clear depiction of...

• Phenotypic diversity of the lung vasculature in experimental models of metastases

  Authors:Yun Oh, Imran Mohiuddin, Yah Sun, Joseph B. Putnam, Jr., Waun Ki Hong, Wadih Arap, et al.From:Chest (Vol. 128, Issue 6) Peer-Reviewed

  Dec. 20051,979 words Article In vivo phage display is a screening method in which peptides homing to specific vascular beds are selected after IV administration of a random peptide library. This strategy has revealed a vascular address system that...

• Heterogeneity of Tumor Vasculature and Antiangiogenic Intervention: Insights from MR Angiography and DCE-MRI

  Authors:Wenlian Zhu, Yoshinori Kato, and Dmitri ArtemovFrom:PLoS ONE (Vol. 9, Issue 1) Peer-Reviewed

  Jan. 23, 20144,598 words Article 1630LAuthor(s): Wenlian Zhu 1, Yoshinori Kato 1,2, Dmitri Artemov 1,2,* Introduction Intratumoral vascular heterogeneity is an important feature of the solid tumors [1], [2] and needs to be considered when the...

• Tumor Vasculature-Targeted Recombinant Mutated Human TNF-[alpha] Enhanced the Antitumor Activity of Doxorubicin by Increasing Tumor Vessel Permeability in Mouse Xenograft Models

  Authors:Changli Jiang, Junzhou Niu, Meng Li, Yi Teng, Huixuan Wang, and Yingqi ZhangFrom:PLoS ONE (Vol. 9, Issue 1) Peer-Reviewed

  Jan. 22, 20145,485 words Article 1490LAuthor(s): Changli Jiang 1,2, Junzhou Niu 3, Meng Li 2, Yi Teng 1, Huixuan Wang 1,*, Yingqi Zhang 2,* Introduction Tumor necrosis factor-[alpha] (TNF-[alpha]) exhibits potent antitumor activity, alters endothelial...

• Tumor Vascularity and Glucose Metabolism Correlated in Adenocarcinoma, but Not in Squamous Cell Carcinoma of the Lung

  Authors:Jiuquan Zhang, Lihua Chen, Yongfeng Chen, Wenwei Wang, Lin Cheng, Xiangdong Zhou, et al.From:PLoS ONE (Vol. 9, Issue 3) Peer-Reviewed

  Mar. 10, 20144,473 words Article 1520LAuthor(s): Jiuquan Zhang 1, Lihua Chen 1, Yongfeng Chen 2, Wenwei Wang 2, Lin Cheng 1, Xiangdong Zhou 2,*, Jian Wang 1,* Introduction For therapeutic purposes, non-small cell lung cancer (NSCLC) has traditionally...

• Selective Alpha-Particle Mediated Depletion of Tumor Vasculature with Vascular Normalization

  Authors:Jaspreet Singh Jaggi, Erik Henke, Surya V. Seshan, Barry J. Kappel, Debjit Chattopadhyay, Chad May, et al.From:PLoS ONE (Vol. 2, Issue 3) Peer-Reviewed

  Mar. 7, 20076,342 words Article 1570LBackground Abnormal regulation of angiogenesis in tumors results in the formation of vessels that are necessary for tumor growth, but compromised in structure and function. Abnormal tumor vasculature impairs oxygen...

• The nuances of therapy: oncologists use drugs that limit a tumour's blood supply to prevent its growth. Although the initial effects of these drugs are beneficial to patients, new data suggest that their long-term effects warrant further study

  Authors:Lee M. Ellis and David A. ReardonFrom:Nature (Vol. 458, Issue 7236) Peer-Reviewed

  Mar. 19, 20091,361 words Report 1520LAngiogenesis--the formation of new blood vessels--is a hallmark of cancer, and allows tumour growth. Anti-angiogenic therapy offers great promise and is often used to treat cancer, either alone or in combination with...

• DCE-MRI assessment of the effect of vandetanib on tumor vasculature in patients with advanced colorectal cancer and liver metastases: a randomized phase I study

  Authors:Klaus Mross, Ulrike Fasol, Annette Frost, Robin Benkelmann, Jan Kuhlmann, Martin Buchert, et al.From:Journal of Angiogenesis Research (Vol. 1) Peer-Reviewed

  Sept. 21, 20096,784 words Report Authors: Klaus Mross (corresponding author) [1]; Ulrike Fasol [2]; Annette Frost [1]; Robin Benkelmann [1]; Jan Kuhlmann [3]; Martin Büchert [2]; Clemens Unger [1]; Hubert Blum [3]; Jürgen Hennig [2]; Tsveta P Milenkova...

• M1-like macrophages change tumor blood vessels and microenvironment in murine melanoma

  Authors:Magdalena Jarosz-Biej, Natalia Kaminska, Sybilla Matuszczak, Tomasz Cichon, Jolanta Pamula-Pilat, Justyna Czapla, et al.From:PLoS ONE (Vol. 13, Issue 1) Peer-Reviewed

  Jan. 10, 201810,721 words Article 1330LAuthor(s): Magdalena Jarosz-Biej *, Natalia Kaminska, Sybilla Matuszczak, Tomasz Cichon, Jolanta Pamula-Pilat, Justyna Czapla, Ryszard Smolarczyk, Daria Skwarzynska, Klaudia Kulik, Stanislaw Szala Introduction...

• Autotaxin and LPA Receptors Represent Potential Molecular Targets for the Radiosensitization of Murine Glioma through Effects on Tumor Vasculature

  Authors:Stephen M. Schleicher, Dinesh K. Thotala, Amanda G. Linkous, Rong Hu, Kathleen M. Leahy, Eugenia M. Yazlovitskaya, et al.From:PLoS ONE (Vol. 6, Issue 7) Peer-Reviewed

  July 20, 20117,006 words Article 1480LDespite wide margins and high dose irradiation, unresectable malignant glioma (MG) is less responsive to radiation and is uniformly fatal. We previously found that cytosolic phospholipase A2 (cPLA.sub.2) is a molecular...

• Room to breathe

  From:Nature (Vol. 457, Issue 7232) Peer-Reviewed

  Feb. 19, 2009124 words Brief article, Repor... Cell doi:10.1016/j.cell.2009.01.020 (2009) Improving the condition of tumour blood vessels may reduce the likelihood that the cancer will spread. Abnormal blood vessels inside tumours impede the delivery of oxygen...

• Tumor endothelial marker 1-specific DNA vaccination targets tumor vasculature

  Authors:John G. Facciponte, Stefano Ugel, Francesco De Sanctis, Chunsheng Li, Liping Wang, Gautham Nair, et al.From:Journal of Clinical Investigation (Vol. 124, Issue 4) Peer-Reviewed

  Apr. 20149,482 words Report 1380LTumor endothelial marker 1 (TEM1; also known as endosialin or CD248) is a protein found on tumor vasculature and in tumor stroma. Here, we tested whether TEM1 has potential as a therapeutic target for cancer...

• Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming

  Authors:Lin Tian, Amit Goldstein, Hai Wang, Hin Ching Lo, Ik Sun Kim, Thomas Welte, et al.From:Nature (Vol. 544, Issue 7649) Peer-Reviewed

  Apr. 13, 201711,749 words Report 1460LAuthor(s): Lin Tian [1, 2, 3]; Amit Goldstein [1, 2, 4]; Hai Wang [1, 2, 4]; Hin Ching Lo [1, 2, 5]; Ik Sun Kim [1, 2, 5]; Thomas Welte [1, 2, 4]; Kuanwei Sheng [5, 6]; Lacey E. Dobrolecki [1]; Xiaomei Zhang [1];...

• Upregulation of annexin A1 protein expression in the intratumoral vasculature of human non-small-cell lung carcinoma and rodent tumor models

  Authors:Kevin L. Allen, Jennifer Cann, Weiguang Zhao, Norman Peterson, Michelle Lazzaro, Haihong Zhong, et al.From:PLoS ONE (Vol. 15, Issue 6) Peer-Reviewed

  June 4, 20208,036 words Report 1560LAuthor(s): Kevin L. Allen 1, Jennifer Cann 2, Weiguang Zhao 2, Norman Peterson 2, Michelle Lazzaro 3, Haihong Zhong 3, Herren Wu 1, William F. Dall'Acqua 1, M. Jack Borrok 1, Melissa M. Damschroder 1, Ping Tsui 1, Qing...

• Non-invasive qualitative and semiquantitative presurgical investigation of the feeding vasculature to intracranial meningiomas using superselective arterial spin labeling.

  Authors:Ulf Jensen-Kondering, Michael Helle, Thomas Lindner, Olav Jansen, and Arya NabaviFrom:PLoS ONE (Vol. 14, Issue 4) Peer-Reviewed

  Apr. 9, 20193,853 words Report 1430LBackground Intracranial meningiomas may be amenable to presurgical embolization to reduce bleeding complications. Detailed information usually obtained by digital subtraction angiography (DSA) on the contribution of...

• Development of an orally-administrable tumor vasculature-targeting therapeutic using annexin A1-binding D-peptides

  Authors:Motohiro Nonaka, Hideaki Mabashi-Asazuma, Donald L. Jarvis, Kazuhiko Yamasaki, Tomoya O. Akama, Masato Nagaoka, et al.From:PLoS ONE (Vol. 16, Issue 1) Peer-Reviewed

  Jan. 6, 20216,965 words Report 1470LWe previously reported that IF7 peptide, which binds to the annexin A1 (ANXA1) N-terminus, functions as a tumor vasculature-targeted drug delivery vehicle after intravenous injection. To enhance IF7 stability in vivo,...

• Cabozantinib can block growth of neuroendocrine prostate cancer patient-derived xenografts by disrupting tumor vasculature.

  Authors:Mark P. Labrecque, Lisha G. Brown, Ilsa M. Coleman, Holly M. Nguyen, Daniel W. Lin, Eva Corey, et al.From:PLoS ONE (Vol. 16, Issue 1) Peer-Reviewed

  Jan. 20, 20218,056 words Report 1500LWith the advent of potent second-line anti-androgen therapy, we and others have observed an increased incidence of androgen receptor (AR)-null small cell or neuroendocrine prostate cancer (SCNPC) in metastatic...

• Targeting the tumor vasculature: a strategy to improve radiation therapy

  Authors:Dietmar W. Siemann and Michael R. HorsmanFrom:Expert Review of Anticancer Therapy (Vol. 4, Issue 2) Peer-Reviewed

  Apr. 20044,805 words Report A continuously expanding vasculature is an essential requirement of a growing neoplastic mass. The blood-vessel network provides not only nutritional support and waste product management, but also offers opportunities...

• Recombinant Human Endostatin Normalizes Tumor Vasculature and Enhances Radiation Response in Xenografted Human Nasopharyngeal Carcinoma Models

  Authors:Fang Peng, Zumin Xu, Jin Wang, Yuanyuan Chen, Qiang Li, Yufang Zuo, et al.From:PLoS ONE (Vol. 7, Issue 4) Peer-Reviewed

  Apr. 9, 20126,328 words Report 1400LAuthor(s): Fang Peng 1 , 2 , Zumin Xu 1 , 2 , 3 , Jin Wang 1 , 2 , Yuanyuan Chen 1 , 2 , Qiang Li 4 , Yufang Zuo 3 , Jing Chen 5 , Xiao Hu 1 , 2 , Qichao Zhou 1 , 2 , Yan Wang 1 , 2 , Honglian Ma 1 , 2 , Yong Bao 1 , 2...