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Academic Journals
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From:Nature (Vol. 521, Issue 7553) Peer-ReviewedImpaired mitochondrial maintenance in disparate cell types is a shared hallmark of many human pathologies and ageing (1-8). How mitochondrial biogenesis coordinates with the removal of damaged or superfluous...
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From:Expert Review of Proteomics (Vol. 8, Issue 2) Peer-ReviewedAuthor(s): Juergen Kast 1 Keywords : Caenorhabditis elegans ; let-7; microRNA; prediction tools; proteomics; selected ion monitoring; target validation The ultimate goal of biological research is to fully...
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From:Science (Vol. 282, Issue 5396) Peer-ReviewedNeurotransmitter receptors, neurotransmitter synthesis and release pathways, and heterotrimeric GTP-binding protein (G protein)-coupled second messenger pathways are highly conserved between Caenorhabditis elegans and...
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From:Science (Vol. 243, Issue 4894) Peer-ReviewedGenetic Control of Differentiation of the Caenorhabditis elegants Touch Receptor Neurons NERVOUS SYSTEMS CONSIST OF MANY TYPES OF NEURONS that differ from each other structurally and biochemically in such features as...
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From:Science (Vol. 263, Issue 5147) Peer-ReviewedAge-specific mortality rates in isogenic populations of the nematode Caenorhabditis elegans increase exponentially throughout life. In genetically heterogeneous populations, age-specific mortality increases exponentially...
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From:PLoS ONE (Vol. 9, Issue 3) Peer-ReviewedAuthor(s): Yan Qiao 1,2, Yunli Zhao 2, Qiuli Wu 2, Lingmei Sun 2, Qinli Ruan 1, Yanyan Chen 1, Meng Wang 1,*, Jinao Duan 1,*, Dayong Wang 2,* Introduction Genkwa Flos (GF), the dried flower bud from Daphne genkwa...
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From:Nature Biotechnology (Vol. 34, Issue 9) Peer-ReviewedAuthor(s): Judith Besseling [1]; Henrik Bringmann (corresponding author) [1] The ability to rewrite the rules of genetic segregation would open new possibilities in diverse areas of biotechnology ranging from...
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From:PLoS ONE (Vol. 7, Issue 8) Peer-ReviewedAuthor(s): Qiuli Wu 1 , Yiping Li 1 , Meng Tang 2 , Dayong Wang 1 , * Introduction Iron oxide nanoparticles (NPs) hold immense potential in a vast variety of applications such as magnetic resonance imaging,...
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From:Nature (Vol. 457, Issue 7230) Peer-ReviewedDietary restriction is the most effective and reproducible intervention to extend lifespan in divergent species (1). In mammals, two regimens of dietary restriction, intermittent fasting (IF) and chronic caloric...
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From:Evidence - Based Complementary and Alternative Medicine (Vol. 2017) Peer-ReviewedAlzheimer's disease (AD) is an age-related neurodegenerative disorder, and the few drugs that are currently available only treat the symptoms. Traditional medicine or phytotherapy has been shown to protect against AD....
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From:PLoS ONE (Vol. 4, Issue 11) Peer-ReviewedAuthor(s): Vaughn S. Cooper 1,*, Wendy A. Carlson 1, John J. LiPuma 2 Introduction To understand why only some bacteria are prone to cause disease, it is important to study how they interact with the organisms...
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From:PLoS ONE (Vol. 14, Issue 4) Peer-ReviewedWe observed that heat shock of Caenorhabditis elegans leads to the formation of nuclear double-stranded RNA (dsRNA) foci, detectable with a dsRNA-specific monoclonal antibody. These foci significantly overlap with...
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From:PLoS ONE (Vol. 7, Issue 9) Peer-ReviewedThe male and the hermaphrodite forms of the nematode Caenorhabditis elegans (C. elegans) differ markedly in anatomy, nervous system and behavior at adulthood. Using the male mutants fog-2, him-5, and him-8, we compared...
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From:PLoS ONE (Vol. 4, Issue 8) Peer-ReviewedThe cuticle of Caenorhabditis elegans, a complex, multi-layered extracellular matrix, is a major interface between the animal and its environment. Biofilms produced by the bacterial genus Yersinia attach to the cuticle...
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From:Silence (Vol. 1) Peer-ReviewedBackground Antisense reagents can serve as efficient and versatile tools for studying gene function by inhibiting nucleic acids in vivo. Antisense reagents have particular utility for the experimental manipulation of...
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From:PLoS ONE (Vol. 6, Issue 9) Peer-ReviewedThe intestinal peptide transporter PEPT-1 in Caenorhabditis elegans is a rheogenic H.sup.+ -dependent carrier responsible for the absorption of di- and tripeptides. Transporter-deficient pept-1(lg601) worms are...
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From:PLoS ONE (Vol. 5, Issue 9) Peer-ReviewedThe nematode Caenorhabditis elegans has been employed as a model organism to study human obesity due to the conservation of the pathways that regulate energy metabolism. To assay for fat storage in C. elegans, a number...
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From:PLoS ONE (Vol. 5, Issue 2) Peer-ReviewedDisruption of dopamine homeostasis may lead to dopaminergic neuron degeneration, a proposed explanation for the specific vulnerability of dopaminergic neurons in Parkinson's disease. While expression of human...
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From:PLoS ONE (Vol. 4, Issue 1) Peer-ReviewedWhen Caenorhabditis elegans senses dauer pheromone (daumone), signaling inadequate growth conditions, it enters the dauer state, which is capable of long-term survival. However, the molecular pathway of dauer entry in...
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From:PLoS ONE (Vol. 6, Issue 10) Peer-ReviewedIn Pseudomonas aeruginosa, the expression of a number of virulence factors, as well as biofilm formation, are controlled by quorum sensing (QS). N-Acylhomoserine lactones (AHLs) are an important class of signaling...