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    Academic Journals

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• Alternatives to calcineurin inhibition in renal transplantation: belatacept, the first co-stimulation blocker

  Authors:Nicolas Poirier, Gilles Blancho, and Bernard VanhoveFrom:Immunotherapy (Vol. 2, Issue 5) Peer-Reviewed

  Sept. 20108,196 words Clinical report Author(s): Nicolas Poirier 1 2 3 , Gilles Blancho 1 2 3 , Bernard Vanhove [[dagger]] 4 KEYWORDS: co-stimulation blockade; CTLA4-Ig; kidney transplantation; T-cell activation Kidney transplantation dramatically...

• A proteomic interrogation of Cryptococcus neoformans: interaction networks for calcineurin in a heated environment

  Authors:Oleh A Mulyar, Allen CT Teng, and Anthony O GramoliniFrom:Expert Review of Proteomics (Vol. 9, Issue 1) Peer-Reviewed

  Feb. 20122,023 words Report 1400LAuthor(s): Oleh A Mulyar 1 , Allen CT Teng 1 , Anthony O Gramolini [**] 2 Keywords : calcineurin; calmodulin; coatomer proteins; mass spectrometry; protein-protein interaction Cryptococcal yeasts are...

• Genetic and pharmacological inhibition of calcineurin corrects the BDNF transport defect in Huntington's disease

  Authors:Jose R. Pineda, Raul Pardo, Diana Zala, Hua Yu, Sandrine Humbert, and Frederic SaudouFrom:Molecular Brain (Vol. 2) Peer-Reviewed

  Oct. 27, 20097,445 words Report Authors: Jose R Pineda [1,2]; Raúl Pardo [1,2]; Diana Zala [1,2]; Hua Yu [1,2]; Sandrine Humbert [1,2]; Frédéric Saudou (corresponding author) [1,2] Background An abnormal polyglutamine (polyQ) expansion in the...

• Topical calcineurin inhibitors can still be used in children

  Author:Robert FinnFrom:Family Practice News (Vol. 35, Issue 20)

  Oct. 15, 2005463 words Article BLAINE, WASH. -- Topical calcineurin inhibitors remain an excellent second-line treatment for atopic dermatitis in children, despite a public health advisory by the Food and Drug Administration earlier this year and the...

• Calcineurin signaling pathway influences Aspergillus niger biofilm formation by affecting hydrophobicity and cell wall integrity.

  Authors:Li Liu, Bin Yu, Wenjun Sun, Caice Liang, Hanjie Ying, Shengmin Zhou, et al.From:Biotechnology for Biofuels (Vol. 13, Issue 1) Peer-Reviewed

  Mar. 16, 20206,847 words Report 1490LBackground Biofilms, as a kind of fixed-cell community, can greatly improve industrial fermentation efficiency in immobilized fermentation, but the regulation process is still unclear, which restricts their...

• Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1

  Authors:Kwan-Hyuck Baek, Alexander Zaslavsky, Ryan C. Lynch, Carmella Britt, Yoshiaki Okada, Richard J. Siarey, et al.From:Nature (Vol. 459, Issue 7250) Peer-Reviewed

  June 25, 20094,744 words Clinical report 1480LThe incidence of many cancer types is significantly reduced in individuals with Down's syndrome (1-4), and it is thought that this broad cancer protection is conferred by the increased expression of one or more of the...

• Calcineurin inhibitors target Lck activation in graft-versus-host disease.

  Authors:Nicole M. Carter and Joel L. PomerantzFrom:Journal of Clinical Investigation (Vol. 131, Issue 11) Peer-Reviewed

  June 1, 20211,868 words Report 1450LCalcineurin inhibitors (CNIs) such as cyclosporin A and FK506 are widely administered immunosuppressive drugs. Calcineurin relieves inhibitory phosphorylation from nuclear factor of activated T cells (NFAT) transcription...

• Calcineurin inhibitors in pediatric atopic dermatitis: a review of current evidence

  Authors:Manjunatha Kalavala and Magdalene A. DohilFrom:American Journal of Clinical Dermatology (Vol. 12, Issue 1) Peer-Reviewed

  January-February 20116,729 words Clinical report 1750LAtopic dermatitis (AD) is a common, chronic inflammatory dermatosis with a prevalence of 7-21% in school-aged children. Childhood AD has a profound impact on the social, personal, emotional, and financial perspectives...

• ACTN3 genotype influences muscle performance through the regulation of calcineurin signaling

  Authors:Jane T. Seto, Kate G.R. Quinlan, Monkol Lek, Xi Fiona Zheng, Fleur Garton, Daniel G. MacArthur, et al.From:Journal of Clinical Investigation (Vol. 123, Issue 10) Peer-Reviewed

  Oct. 20136,076 words Report 1470L[alpha]-Actinin-3 deficiency occurs in approximately 16% of the global population due to homozygosity for a common nonsense polymorphism in the ACTN3 gene. Loss of [alpha]-actinin-3 is associated with reduced power and...

• New concepts to individualize calcineurin inhibitor therapy in renal allograft recipients

  Authors:Claudia Sommerer, Thomas Giese, Stefan Meuer, and Martin ZeierFrom:Saudi Journal of Kidney Diseases and Transplantation (Vol. 21, Issue 6) Peer-Reviewed

  November-December 20104,012 words Report 2050LByline: Claudia. Sommerer, Thomas. Giese, Stefan. Meuer, Martin. Zeier A maximum of efficacy with a minimum of toxicity is the ultimate goal of immuno-suppressive therapy. Calcineurin inhibitors are widely used as...

• Steroid, calcineurin inhibitor best for AD at different times

  Author:Nancy WalshFrom:Family Practice News (Vol. 35, Issue 19)

  Oct. 1, 2005712 words Article Glasgow, Scotland -- A rational approach to the treatment of atopic dermatitis is to use calcineurin inhibitors and topical corticosteroids in different therapeutic niches, based on a scientific understanding of the...

• Taking out the garbage: cathepsin D and calcineurin in neurodegeneration

  Authors:Andreas Aufschnaiter and Verena KohlerFrom:Neural Regeneration Research (Vol. 12, Issue 11) Peer-Reviewed

  Nov. 20173,479 words Report 1630LByline: Andreas. Aufschnaiter, Verena. Kohler, Sabrina. BAaAaAeA ttn Cellular homeostasis requires a tightly controlled balance between protein synthesis, folding and degradation. Especially long-lived, post-mitotic...

• Electrical field stimulation induces cardiac fibroblast proliferation through the calcineurin-NFAT pathway

  Authors:Qing-Qing Chen, Wei Zhang, Xiang-Fan Chen, Yun-Jian Bao, Jing Wang, and Wei-Zhong ZhuFrom:Canadian Journal of Physiology and Pharmacology (Vol. 90, Issue 12) Peer-Reviewed

  Dec. 20126,000 words Report 1480LMost cardiac diseases are associated with fibrosis. Calcineurin (CaN) is regulated by [Ca.sup.2+]/calmodulin (CaM). The CaN-NFAT (nuclear factor of activated T cell) pathway is involved in the process of cardiac...

• Combination atopic dermatitis therapy reduces adverse effects

  From:Formulary (Vol. 39, Issue 5) Peer-Reviewed

  May 2004338 words Brief article Concomitant administration of a calcineurin inhibitor and a corticosteroid for atopic dermatitis is more effective and associated with fewer adverse effects than either alone, according to results presented at the 62nd...

• Calcineurin is required to release Xenopus egg extracts from meiotic M phase

  Authors:Satoru Mochida and Tim HuntFrom:Nature (Vol. 449, Issue 7160) Peer-Reviewed

  Sept. 20, 20074,814 words Clinical report 1460LFertilization induces a transient increase in cytoplasmic [Ca.sup.2+] concentration in animal eggs that releases them from cell cycle arrest in the second meiotic metaphase (1). In frog eggs, [Ca.sup.2+] activates...

• Opposing roles for calcineurin and ATF3 in squamous skin cancer

  Authors:Xunwei Wu, Bach-Cuc Nguyen, Piotr Dziunycz, Sungeun Chang, Yang Brooks, Karine Lefort, et al.From:Nature (Vol. 465, Issue 7296) Peer-Reviewed

  May 20, 20104,568 words Report 1520LCalcineurin inhibitors such as cyclosporin A (CsA) are the mainstay of immunosuppressive treatment for organ transplant recipients. Squamous cell carcinoma (SCC) of the skin is a major complication of treatment with...

• Calcineurin inhibitor-free CD28 blockade-based protocol protects allogeneic islets in nonhuman primates. (Rapid Publication)

  Authors:Andrew B. Adams, Nozomu Shirasugi, Megan M. Durham, Elizabeth Strobert, Dan Anderson, Phyllis Rees, et al.From:Diabetes (Vol. 51, Issue 2) Peer-Reviewed

  Feb. 20024,317 words Article Recent success using a steroid-free immunosuppressive regimen has renewed enthusiasm for the use of islet transplantation to treat diabetes. Toxicities associated with the continued use of a calcineurin inhibitor may...

• Calcineurin inhibitors suppress acute graft-versus-host disease via NFAT-independent inhibition of T cell receptor signaling.

  Authors:Shizuka Otsuka, Nicolas Melis, Matthias M. Gaida, Debjani Dutta, Roberto Weigert, and Jonathan D. AshwellFrom:Journal of Clinical Investigation (Vol. 131, Issue 11) Peer-Reviewed

  June 1, 202111,262 words Report 1400LInhibitors of calcineurin phosphatase activity (CNIs) such as cyclosporin A (CsA) are widely used to treat tissue transplant rejection and acute graft-versus-host disease (aGVHD), for which inhibition of gene expression...

• A retrospective study of the utility of targeted phototherapy in vitiligo

  Authors:Abhijit Raghuwanshi, Minty Jambhore, Vishalakshi Viswanath, and Vinay GopalaniFrom:Indian Journal of Dermatology, Venereology, and Leprology (Vol. 84, Issue 1) Peer-Reviewed

  January-February 20182,371 words Article 1560LByline: Abhijit. Raghuwanshi, Minty. Jambhore, Vishalakshi. Viswanath, Vinay. Gopalani Background: Targeted phototherapy is a recent advance in the treatment of vitiligo, involving selective treatment of vitiligo...

• Sequential alterations in Akt, GSK3[beta], and calcineurin signalling in the mouse left ventricle after thoracic aortic constriction

  Authors:Miresta Previlon, Mylene Pezet, Celine Dachez, Jean-Jacques Mercadier, and Patricia Rouet-BenzinebFrom:Canadian Journal of Physiology and Pharmacology (Vol. 88, Issue 11) Peer-Reviewed

  Nov. 20104,849 words Report 1430LLeft ventricular hypertrophy (LVH) is an adaptive response to chronic biomechanical stress that generally progresses to maladaptive hypertrophy and heart failure (HF). We studied the activation of protein kinase B...