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From:Science (Vol. 262, Issue 5133) Peer-ReviewedThe voltage-activated rabbit cardiac calcium channel [alpha.sub.1] subunit was expressed in Xenopus oocytes. The charge movement of its voltage sensor was measured and related to the opening of the ion-conducting pore....
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From:PLoS ONE (Vol. 9, Issue 2) Peer-ReviewedAuthor(s): Toshihiko Fukuda, Takahiro Kuroda, Miki Kono, Takahisa Miyamoto, Mitsuru Tanaka, Toshiro Matsui * Introduction It has been reported that aging greatly affects vessel tone and arterial stiffness [1],...
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From:BioMed Research InternationalPeer-ReviewedThe aim of this study was to investigate the effects of nitric oxide (NO) and reactive oxygen species (ROS) on L-type calcium channel (LTCC) gating properties of cardiomyocytes during long-term isoproterenol (ISO)...
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From:Journal of Clinical Investigation (Vol. 117, Issue 5) Peer-ReviewedRyR2 is a [Ca.sup.2+] release channel expressed by cardiac muscle cells that has an important role in cardiac excitation-contraction coupling. In vitro studies have shown that calmodulin (CaM) inhibits RyR2 function,...
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From:Journal of Reproduction and Infertility (Vol. 19, Issue 3) Peer-ReviewedBackground: Intracellular calcium and proton concentrations are important factors for activating human sperm. Calcium ion ([Ca.sup.2+]) enters sperm through voltage-dependent calcium channel of sperm (CatSper). Proton...
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From:BMC Research Notes (Vol. 12, Issue 1) Peer-ReviewedObjectives Voltage-gated Ca.sup.2+ channels (VGCCs) are of central relevance in regulating Ca.sup.2+ influx into living cells. The low-voltage activated (LVA) Ca.sub.v3 T-type Ca.sup.2+ channels are widely distributed...
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From:BioMed Research InternationalPeer-ReviewedThe activation of [Ca.sup.2+]-dependent [Cl.sup.-] channels during norepinephrine-induced contraction of vascular smooth muscle was suggested to depolarize cell membrane and to increase [Ca.sup.2+] entry. Hypertension...
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From:Nature (Vol. 585, Issue 7826) Peer-ReviewedDisease-causing microorganisms can invade plants through leaf pores called stomata, which close rapidly in a calcium-dependent manner on detecting such danger. The calcium channels involved have now finally been...
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From:PLoS ONE (Vol. 6, Issue 5) Peer-ReviewedGlutathione (GSH), the major endogenous antioxidant produced by cells, can modulate the activity of N-methyl-D-aspartate receptors (NMDARs) through its reducing functions. During aging, an increase in oxidative stress...
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From:PLoS ONE (Vol. 4, Issue 8) Peer-ReviewedBackground To what extent do identified neurons from different animals vary in their expression of ion channel genes? In neurons of the same type, is ion channel expression highly variable and/or is there any...
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From:PLoS ONE (Vol. 6, Issue 3) Peer-ReviewedBackground Recent studies have suggested that vitamin D can act on cells in the nervous system. Associations between polymorphisms in the vitamin D receptor (VDR), age- dependent cognitive decline, and insufficient...
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From:Molecular Brain (Vol. 6, Issue 1) Peer-ReviewedBackground Stromal interaction molecule 1 (STIM1), a Ca.sup.2+ sensor in the endoplasmic reticulum, regulates store-operated Ca.sup.2+ entry (SOCE) that is essential for Ca.sup.2+ homeostasis in many types of cells....
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From:PLoS ONE (Vol. 10, Issue 3) Peer-ReviewedThe enteric nervous system arises from neural crest-derived cells (ENCCs) that migrate caudally along the embryonic gut. The expression of ion channels by ENCCs in embryonic mice was investigated using a PCR-based...
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From:Nature (Vol. 537, Issue 7619) Peer-ReviewedThe voltage-gated calcium (Ca[sub.v]) channels convert membrane electrical signals to intracellular Ca[sup.2+]-mediated events. Among the ten subtypes of Ca[sub.v] channel in mammals, Ca[sub.v]1.1 is specified for the...
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From:Molecular Brain (Vol. 10, Issue 1) Peer-ReviewedCalmodulin (CaM) is an important signaling molecule that regulates a vast array of cellular functions by activating second messengers involved in cell function and plasticity. Low voltage-activated calcium channels of...
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From:PLoS ONE (Vol. 9, Issue 11) Peer-ReviewedThe electrical properties of the heart are primarily determined by the activity of ion channels and the activity of these molecules is permanently modulated and adjusted to the physiological needs by adrenergic...
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From:Neurology India (Vol. 69, Issue 4) Peer-ReviewedByline: Agaath. Manickam, Sivasamy. Ramasamy Background: The voltage-dependent calcium channel a1 subunit (CACNA1A) gene plays a major role in neuronal communication. Mutation in this gene results in altered Ca2+ ion...
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From:Molecular Brain (Vol. 15, Issue 1) Peer-ReviewedLow-voltage-activated T-type Ca.sup.2+ channels are key regulators of neuronal excitability both in the central and peripheral nervous systems. Therefore, their recruitment at the plasma membrane is critical in...
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From:Journal of Clinical Investigation (Vol. 119, Issue 1) Peer-ReviewedFamilial hemiplegic migraine type 1 (FHM1) is an autosomal dominant subtype of migraine with aura that is associated with hemiparesis. As with other types of migraine, it affects women more frequently than men. FHM1 is...
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From:Science (Vol. 302, Issue 5649) Peer-ReviewedCalcium ion ([Ca.sup.2+]) influx through voltage-gated [Ca.sup.2+] channels is important for the regulation of vascular tone. Activation of L-type [Ca.sup.2+] channels initiates muscle contraction; however, the role of...