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    Academic Journals

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• Potentiation by the beta subunit of the ratio of ionic current to the charge movement in the cardiac calcium channel

  Authors:Alan Neely, Xiangyang Wei, Riccardo Olcese, Lutz Birnbaumer, and Enrico StefaniFrom:Science (Vol. 262, Issue 5133) Peer-Reviewed

  Oct. 22, 19932,402 words Article The voltage-activated rabbit cardiac calcium channel [alpha.sub.1] subunit was expressed in Xenopus oocytes. The charge movement of its voltage sensor was measured and related to the opening of the ion-conducting pore....

• Attenuation of L-Type Ca.sup.2+ Channel Expression and Vasomotor Response in the Aorta with Age in Both Wistar-Kyoto and Spontaneously Hypertensive Rats

  Authors:Toshihiko Fukuda, Takahiro Kuroda, Miki Kono, Takahisa Miyamoto, Mitsuru Tanaka, and Toshiro MatsuiFrom:PLoS ONE (Vol. 9, Issue 2) Peer-Reviewed

  Feb. 12, 20145,093 words Article 1480LAuthor(s): Toshihiko Fukuda, Takahiro Kuroda, Miki Kono, Takahisa Miyamoto, Mitsuru Tanaka, Toshiro Matsui * Introduction It has been reported that aging greatly affects vessel tone and arterial stiffness [1],...

• Nitric oxide protects L-type calcium channel of cardiomyocyte during long-term isoproterenol stimulation in tail-suspended rats

  Authors:Zhi-Jie Yue, Peng-Tao Xu, Bo Jiao, Hui Chang, Zhen Song, Man-Jiang Xie, et al.From:BioMed Research InternationalPeer-Reviewed

  Annual 20155,747 words Report 1330LThe aim of this study was to investigate the effects of nitric oxide (NO) and reactive oxygen species (ROS) on L-type calcium channel (LTCC) gating properties of cardiomyocytes during long-term isoproterenol (ISO)...

• RyR2 mutants have big hearts

  From:Journal of Clinical Investigation (Vol. 117, Issue 5) Peer-Reviewed

  May 2007182 words Brief article, Clini... 1540LRyR2 is a [Ca.sup.2+] release channel expressed by cardiac muscle cells that has an important role in cardiac excitation-contraction coupling. In vitro studies have shown that calmodulin (CaM) inhibits RyR2 function,...

• Effect of CatSper and Hv1 Channel Inhibition on Progesterone Stimulated Human Sperm

  Authors:Sara Keshtgar, Hamideh Ghanbari, Esmaeel Ghani, and Seyed Mostafa Shid MoosaviFrom:Journal of Reproduction and Infertility (Vol. 19, Issue 3) Peer-Reviewed

  July-September 20183,826 words Report 1270LBackground: Intracellular calcium and proton concentrations are important factors for activating human sperm. Calcium ion ([Ca.sup.2+]) enters sperm through voltage-dependent calcium channel of sperm (CatSper). Proton...

• Gender specific click and tone burst evoked ABR datasets from mice lacking the Cav3.2 T-type voltage-gated calcium channel.

  Authors:Andreas Lundt, Christina Henseler, Carola Wormuth, Julien Soos, Robin Seidel, Ralf Müller, et al.From:BMC Research Notes (Vol. 12, Issue 1) Peer-Reviewed

  Mar. 20, 20191,661 words Article 1390LObjectives Voltage-gated Ca.sup.2+ channels (VGCCs) are of central relevance in regulating Ca.sup.2+ influx into living cells. The low-voltage activated (LVA) Ca.sub.v3 T-type Ca.sup.2+ channels are widely distributed...

• Contribution of [Ca.sup.2+]-dependent [Cl.sup.-] channels to norepinephrine-induced contraction of femoral artery is replaced by increasing EDCF contribution during ageing

  Authors:Silvia Liskova, Miriam Petrova, Petr Karen, Michal Behuliak, and Josef ZichaFrom:BioMed Research InternationalPeer-Reviewed

  Annual 20145,176 words Report 1480LThe activation of [Ca.sup.2+]-dependent [Cl.sup.-] channels during norepinephrine-induced contraction of vascular smooth muscle was suggested to depolarize cell membrane and to increase [Ca.sup.2+] entry. Hypertension...

• Calcium channel in plants helps shut the door on intruders

  Authors:Keiko Yoshioka and Wolfgang MoederFrom:Nature (Vol. 585, Issue 7826) Peer-Reviewed

  Sept. 24, 20201,796 words Article 1510LDisease-causing microorganisms can invade plants through leaf pores called stomata, which close rapidly in a calcium-dependent manner on detecting such danger. The calcium channels involved have now finally been...

• Glutathione Restores the Mechanism of Synaptic Plasticity in Aged Mice to That of the Adult

  Authors:Julie M. Robillard, Grant R. Gordon, Hyun B. Choi, Brian R. Christie, and Brian A. MacVicarFrom:PLoS ONE (Vol. 6, Issue 5) Peer-Reviewed

  May 31, 20115,316 words Article 1410LGlutathione (GSH), the major endogenous antioxidant produced by cells, can modulate the activity of N-methyl-D-aspartate receptors (NMDARs) through its reducing functions. During aging, an increase in oxidative stress...

• Correlations in Ion Channel mRNA in Rhythmically Active Neurons

  Authors:Anne-Elise Tobin, Nelson D. Cruz-Bermudez, Eve Marder, and David J. SchulzFrom:PLoS ONE (Vol. 4, Issue 8) Peer-Reviewed

  Aug. 25, 20096,479 words Article 1500LBackground To what extent do identified neurons from different animals vary in their expression of ion channel genes? In neurons of the same type, is ion channel expression highly variable and/or is there any...

• The Effects of Vitamin D Receptor Silencing on the Expression of LVSCC-A1C and LVSCC-A1D and the Release of NGF in Cortical Neurons

  Authors:Duygu Gezen-Ak, Erdinc Dursun, and Selma YilmazerFrom:PLoS ONE (Vol. 6, Issue 3) Peer-Reviewed

  Mar. 3, 20116,713 words Article 1490LBackground Recent studies have suggested that vitamin D can act on cells in the nervous system. Associations between polymorphisms in the vitamin D receptor (VDR), age- dependent cognitive decline, and insufficient...

• A critical role for STIM1 in filopodial calcium entry and axon guidance

  Authors:Sangwoo Shim, James Q Zheng, and Guo-li MingFrom:Molecular Brain (Vol. 6, Issue 1) Peer-Reviewed

  Dec. 1, 20138,950 words Report 1430LBackground Stromal interaction molecule 1 (STIM1), a Ca.sup.2+ sensor in the endoplasmic reticulum, regulates store-operated Ca.sup.2+ entry (SOCE) that is essential for Ca.sup.2+ homeostasis in many types of cells....

• Ion Channel Expression in the Developing Enteric Nervous System

  Authors:Caroline S. Hirst, Jaime P. P. Foong, Lincon A. Stamp, Emily Fegan, Stephan Dent, Edward C. Cooper, et al.From:PLoS ONE (Vol. 10, Issue 3) Peer-Reviewed

  Mar. 23, 20159,153 words Article 1610LThe enteric nervous system arises from neural crest-derived cells (ENCCs) that migrate caudally along the embryonic gut. The expression of ion channels by ENCCs in embryonic mice was investigated using a PCR-based...

• Structure of the voltage-gated calcium channel Cav1.1 at 3.6 resolution

  Authors:Jianping Wu, Zhen Yan, Zhangqiang Li, Xingyang Qian, Shan Lu, Mengqiu Dong, et al.From:Nature (Vol. 537, Issue 7619) Peer-Reviewed

  Sept. 8, 20169,756 words Report 1510LThe voltage-gated calcium (Ca[sub.v]) channels convert membrane electrical signals to intracellular Ca[sup.2+]-mediated events. Among the ten subtypes of Ca[sub.v] channel in mammals, Ca[sub.v]1.1 is specified for the...

• A T-type channel-calmodulin complex triggers [alpha]CaMKII activation

  Authors:Hadhimulya Asmara, Ileana Micu, Arsalan P. Rizwan, Giriraj Sahu, Brett A. Simms, Fang-Xiong Zhang, et al.From:Molecular Brain (Vol. 10, Issue 1) Peer-Reviewed

  Aug. 11, 20178,899 words Report 1630LCalmodulin (CaM) is an important signaling molecule that regulates a vast array of cellular functions by activating second messengers involved in cell function and plasticity. Low voltage-activated calcium channels of...

• MiRNA-1/133a Clusters Regulate Adrenergic Control of Cardiac Repolarization

  Authors:Johannes Besser, Daniela Malan, Katharina Wystub, Angela Bachmann, Astrid Wietelmann, Philipp Sasse, et al.From:PLoS ONE (Vol. 9, Issue 11) Peer-Reviewed

  Nov. 21, 201412,150 words Article 1540LThe electrical properties of the heart are primarily determined by the activity of ion channels and the activity of these molecules is permanently modulated and adjusted to the physiological needs by adrenergic...

• Mutations in the Voltage Dependent Calcium Channel CACNA1A (P/Q type alpha 1A subunit) Causing Neurological Disorders - An Overview.

  Authors:Agaath Manickam and Sivasamy RamasamyFrom:Neurology India (Vol. 69, Issue 4) Peer-Reviewed

  July-August 20216,779 words Disease/Disorder ove... 2260LByline: Agaath. Manickam, Sivasamy. Ramasamy Background: The voltage-dependent calcium channel a1 subunit (CACNA1A) gene plays a major role in neuronal communication. Mutation in this gene results in altered Ca2+ ion...

• Secretory carrier-associated membrane protein 2 (SCAMP2) regulates cell surface expression of T-type calcium channels.

  Authors:Leos Cmarko, Robin N. Stringer, Bohumila Jurkovicova-Tarabova, Tomas Vacik, Lubica Lacinova, and Norbert WeissFrom:Molecular Brain (Vol. 15, Issue 1) Peer-Reviewed

  Jan. 3, 20222,014 words Article 1750LLow-voltage-activated T-type Ca.sup.2+ channels are key regulators of neuronal excitability both in the central and peripheral nervous systems. Therefore, their recruitment at the plasma membrane is critical in...

• Genetic and hormonal factors modulate spreading depression and transient hemiparesis in mouse models of familial hemiplegic migraine type 1

  Authors:Katharina Eikermann-Haerter, Ergin Dilekoz, Chiho Kudo, Sean I. Savitz, Christian Waeber, Michael J. Baum, et al.From:Journal of Clinical Investigation (Vol. 119, Issue 1) Peer-Reviewed

  Jan. 20098,576 words Report Familial hemiplegic migraine type 1 (FHM1) is an autosomal dominant subtype of migraine with aura that is associated with hemiparesis. As with other types of migraine, it affects women more frequently than men. FHM1 is...

• Abnormal coronary function in mice deficient in [[alpha].sub.1H] T-type [Ca.sup.2+] channels

  Authors:Chien-Chang Chen, Kathryn G. Lamping, Daniel W. Nuno, Rita Barresi, Sally J. Prouty, Julie L. Lavoie, et al.From:Science (Vol. 302, Issue 5649) Peer-Reviewed

  Nov. 21, 20032,391 words Article Calcium ion ([Ca.sup.2+]) influx through voltage-gated [Ca.sup.2+] channels is important for the regulation of vascular tone. Activation of L-type [Ca.sup.2+] channels initiates muscle contraction; however, the role of...