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    Academic Journals

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• Beyond genetics in personalized cancer treatment: assessing dynamics and heterogeneity of tumor responses

  Authors:Darren R Tyson and Vito QuarantaFrom:Personalized Medicine (Vol. 10, Issue 3) Peer-Reviewed

  May 20133,074 words Article 1780LAuthor(s): Darren R Tyson [*] 1 , Vito Quaranta 2 KEYWORDS : cancer therapeutics; dynamic treatment response; single-cell analysis; tumor heterogeneity Cancer has been considered a genetic disease for over a...

• Basal like carcinoma of breast in patient with neurofibromatosis I: An association or co-existence?

  Authors:Sree Jinkala, Nachiappa Rajesh, and Arvind RamkumarFrom:Indian Journal of Pathology and Microbiology (Vol. 56, Issue 2) Peer-Reviewed

  April-June 20131,245 words Article 1830LByline: Sree. Jinkala, Nachiappa. Rajesh, Arvind. Ramkumar Neurofibromatosis I (NF I), an autosomal dominant disorder is associated with increased risk of benign and malignant peripheral nerve sheath tumors and...

• Gene research raises hope of new kidney cancer therapies

  From:Paediatric Nursing (Vol. 22, Issue 4) Peer-Reviewed

  May 2010136 words Brief article 1290LSCIENTISTS HAVE identified two genes that could help in the search for new therapies for the childhood kidney cancer known as Wilms' tumour. The genes, called MYCN and FBXW7, provide an insight into how the disease...

• Complete genome sequencing and network modeling to overcome trastuzumab resistance

  Author:Dimitrios H RoukosFrom:Pharmacogenomics (Vol. 11, Issue 8) Peer-Reviewed

  Aug. 20103,058 words Editorial 1510LAuthor(s): Dimitrios H Roukos 1 KEYWORDS : breast; cancer genome; gastric cancer; molecular networks; trastuzumab resistance Despite advances in our understanding of the molecular basis of traditional single...

• miRNA expression and its clinical implications for the prevention and diagnosis of non-small-cell lung cancer

  Authors:Wen Gao, Jing Xu, and Yong-qian ShuFrom:Expert Review of Respiratory Medicine (Vol. 5, Issue 5) Peer-Reviewed

  Oct. 20119,448 words Article 1550LAuthor(s): Wen Gao 1 , Jing Xu 1 , Yong-qian Shu [[dagger]] 2 Keywords : diagnosis; miRNAs; NSCLC; prevention Lung cancer is the leading cause of cancer-related death worldwide, with a 5-year survival rate...

• The hedgehog/Gli signaling paradigm in prostate cancer

  Authors:Mengqian Chen, Richard Carkner, and Ralph ButtyanFrom:Expert Review of Endocrinology & Metabolism (Vol. 6, Issue 3) Peer-Reviewed

  May 201112,243 words Article 1770LAuthor(s): Mengqian Chen 1 , Richard Carkner 1 , Ralph Buttyan [[dagger]â ] 3 Keywords : androgen signaling; cyclopamine; Gli; hedgehog signaling; prostate cancer; Smoothened Hedgehog is a cell signaling...

• MicroRNAs: the primary cause or a determinant of progression in leukemia?

  Authors:Marina Bousquet and Harvey F LodishFrom:Expert Review of Hematology (Vol. 4, Issue 2) Peer-Reviewed

  Apr. 20112,173 words Editorial 1330LAuthor(s): Marina Bousquet [[dagger]â ] 1 , Harvey F Lodish 2 Keywords : diagnostic tool; leukemia; microRNA; oncogene; prognostic tool; tumor suppressor gene Leukemia is a complex disease with many...

• News & Views in ... Pharmacogenomics

  From:Pharmacogenomics (Vol. 11, Issue 11) Peer-Reviewed

  Nov. 2010515 words Article 1660LThe first signature gene capable of predicting cisplatin/vinorelbine treatment efficacy in non-small-cell lung cancer patients discovered. A collaborative study between the Princess Margaret Hospital (ON, Canada) and...

• New algorithm for studying cancer genes

  From:Expert Review of Neurotherapeutics (Vol. 8, Issue 5) Peer-Reviewed

  May 20081,686 words Article 1460LPublished in the April issue of Cancer Cell , the researchers used a high-resolution genome topography scan (GTS) algorithm to identify gene copy alterations in human glioblastoma (GBM) primary samples and cell lines....

• Cancer genetic association studies in the genome-wide age

  Author:Sharon A SavageFrom:Personalized Medicine (Vol. 5, Issue 6) Peer-Reviewed

  Nov. 20086,333 words Article 1340LAuthor(s): Sharon A Savage 1 Keywords : cancer; cancer risk; genome-wide association study; genomics; population genetics; SNP Genetic risk of cancer Cancer is a complex, multifactorial disease with...

• Pharmaco(epi)genomics in ovarian cancer

  Authors:Adam JW Paige and Robert BrownFrom:Pharmacogenomics (Vol. 9, Issue 12) Peer-Reviewed

  Dec. 20087,764 words Article Author(s): Adam JW Paige [[dagger]] 1 , Robert Brown 1 KEYWORDS: drug resistance; miRNA; polymorphisms; promoter methylation Ovarian cancer is the fourth most common tumor type in women in the UK, with...

• Childhood cancer treatment: an adult comparison

  Author:Jan StyczynskiFrom:Pediatric Health (Vol. 2, Issue 2) Peer-Reviewed

  Apr. 20089,528 words Article Author(s): Jan Styczynski 1 Keywords: acute lymphoblastic leukemia; acute myeloid leukemia; adults; children; individualized therapy; non-Hodgkin lymphoma; targeted therapy Definition of age groups The WHO...

• Risk-based and diagnostics-linked personalized medicine for cancer

  Authors:Sudhir Srivastava and Paul D WagnerFrom:Personalized Medicine (Vol. 4, Issue 1) Peer-Reviewed

  Feb. 20077,880 words Article Author(s): Sudhir Srivastava [[dagger]] 1 , Paul D Wagner 1 Keywords: biomarkers; cancer; oncogenes; raloxifene; risk assessment; tamoxifen; tumor suppressor genes Successful application of personalized...

• Genomic profiling associated with recurrence in patients with rectal cancer treated with chemoradiation

  Authors:Michael A Gordon, Ji Gil, Bo Lu, Wu Zhang, Dongyun Yang, Jim Yun, et al.From:Pharmacogenomics (Vol. 7, Issue 1) Peer-Reviewed

  Jan. 20069,926 words Report 1410LAuthor(s): Michael A Gordon, Ji Gil, Bo Lu, Wu Zhang, Dongyun Yang, Jim Yun, Sylke Schneider, Susan Groshen, Syma Iqbal, Oliver A Press, Katrin Rhodes, Heinz-Josef Lenz [[dagger]] Keywords : cancer;...

• New kinase gene implicated in cancer

  From:Expert Review of Anticancer Therapy (Vol. 4, Issue 2) Peer-Reviewed

  Apr. 2004352 words Brief article 1500LResearchers at the Johns Hopkins Medical Institute (MD, USA) have discovered mutations in a gene linked to the progression of colon and other cancers. The findings may lead to the development of new therapies and...

• Put the blame on methylation: this gene-silencing mechanism, not necessarily mutation, is often found culpable in creating cancerous cells. (Hot Papers)

  Author:Jim KlingFrom:The Scientist (Vol. 17, Issue 12) Peer-Reviewed

  June 16, 20031,560 words Article When good genes go bad and cancer arises, mutation normally gets the blame. But, newer evidence is challenging that one-dimensional view. Epigenetic modifications, such as DNA methylation, can also shut down tumor...

• Structure of the p53 tumor suppressor bound to the ankyrin and SH3 domains of 53BP2

  Authors:Svetlana Gorina and Nikola P. PavletichFrom:Science (Vol. 274, Issue 5289) Peer-Reviewed

  Nov. 8, 19963,473 words Article Mutations in the p53 tumor suppressor are among the most frequently observed genetic alterations in human cancer and map to the 200 -- amino acid core domain of the protein. The core domain contains the sequence-specific...

• Deregulated miRNAs in Hereditary Breast Cancer Revealed a Role for miR-30c in Regulating KRAS Oncogene

  Authors:Miljana Tanic, Kira Yanowsky, Cristina Rodriguez-Antona, Raquel Andres, Ivan Marquez-Rodas, Ana Osorio, et al.From:PLoS ONE (Vol. 7, Issue 6) Peer-Reviewed

  June 11, 20125,657 words Article 1610LAuthor(s): Miljana Tanic 1 , Kira Yanowsky 1 , 2 , Cristina Rodriguez-Antona 3 , Raquel Andrés 4 , Iván Márquez-Rodas 5 , Ana Osorio 1 , 2 , Javier Benitez 1 , 2 , Beatriz Martinez-Delgado 1 , 2 , * Introduction...

• Angiogenic mRNA and microRNA Gene Expression Signature Predicts a Novel Subtype of Serous Ovarian Cancer

  Authors:Stefan Bentink, Benjamin Haibe-Kains, Thomas Risch, Jian-Bing Fan, Michelle S. Hirsch, Kristina Holton, et al.From:PLoS ONE (Vol. 7, Issue 2) Peer-Reviewed

  Feb. 13, 20125,851 words Article 1670LAuthor(s): Stefan Bentink 1 , 6 , Benjamin Haibe-Kains 1 , 6 , Thomas Risch 1 , Jian-Bing Fan 3 , Michelle S. Hirsch 4 , 7 , Kristina Holton 1 , Renee Rubio 1 , Craig April 3 , Jing Chen 3 , Eliza Wickham-Garcia 3 ,...

• Leukemia Gene Atlas - A Public Platform for Integrative Exploration of Genome-Wide Molecular Data

  Authors:Katja Hebestreit, Soren Grottrup, Daniel Emden, Jannis Veerkamp, Christian Ruckert, Hans-Ulrich Klein, et al.From:PLoS ONE (Vol. 7, Issue 6) Peer-Reviewed

  June 14, 20123,148 words Article 1370LAuthor(s): Katja Hebestreit 1 , Sören Gröttrup 1 , Daniel Emden 1 , Jannis Veerkamp 1 , Christian Ruckert 1 , Hans-Ulrich Klein 1 , Carsten Müller-Tidow 2 , Martin Dugas 1 , * Introduction Recent advances in...