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Academic Journals
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From:Personalized Medicine (Vol. 10, Issue 3) Peer-ReviewedAuthor(s): Darren R Tyson [*] 1 , Vito Quaranta 2 KEYWORDS : cancer therapeutics; dynamic treatment response; single-cell analysis; tumor heterogeneity Cancer has been considered a genetic disease for over a...
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From:Indian Journal of Pathology and Microbiology (Vol. 56, Issue 2) Peer-ReviewedByline: Sree. Jinkala, Nachiappa. Rajesh, Arvind. Ramkumar Neurofibromatosis I (NF I), an autosomal dominant disorder is associated with increased risk of benign and malignant peripheral nerve sheath tumors and...
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From:Paediatric Nursing (Vol. 22, Issue 4) Peer-ReviewedSCIENTISTS HAVE identified two genes that could help in the search for new therapies for the childhood kidney cancer known as Wilms' tumour. The genes, called MYCN and FBXW7, provide an insight into how the disease...
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From:Pharmacogenomics (Vol. 11, Issue 8) Peer-ReviewedAuthor(s): Dimitrios H Roukos 1 KEYWORDS : breast; cancer genome; gastric cancer; molecular networks; trastuzumab resistance Despite advances in our understanding of the molecular basis of traditional single...
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From:Expert Review of Respiratory Medicine (Vol. 5, Issue 5) Peer-ReviewedAuthor(s): Wen Gao 1 , Jing Xu 1 , Yong-qian Shu [[dagger]] 2 Keywords : diagnosis; miRNAs; NSCLC; prevention Lung cancer is the leading cause of cancer-related death worldwide, with a 5-year survival rate...
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From:Expert Review of Endocrinology & Metabolism (Vol. 6, Issue 3) Peer-ReviewedAuthor(s): Mengqian Chen 1 , Richard Carkner 1 , Ralph Buttyan [[dagger]â ] 3 Keywords : androgen signaling; cyclopamine; Gli; hedgehog signaling; prostate cancer; Smoothened Hedgehog is a cell signaling...
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From:Expert Review of Hematology (Vol. 4, Issue 2) Peer-ReviewedAuthor(s): Marina Bousquet [[dagger]â ] 1 , Harvey F Lodish 2 Keywords : diagnostic tool; leukemia; microRNA; oncogene; prognostic tool; tumor suppressor gene Leukemia is a complex disease with many...
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From:Pharmacogenomics (Vol. 11, Issue 11) Peer-ReviewedThe first signature gene capable of predicting cisplatin/vinorelbine treatment efficacy in non-small-cell lung cancer patients discovered. A collaborative study between the Princess Margaret Hospital (ON, Canada) and...
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From:Expert Review of Neurotherapeutics (Vol. 8, Issue 5) Peer-ReviewedPublished in the April issue of Cancer Cell , the researchers used a high-resolution genome topography scan (GTS) algorithm to identify gene copy alterations in human glioblastoma (GBM) primary samples and cell lines....
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From:Personalized Medicine (Vol. 5, Issue 6) Peer-ReviewedAuthor(s): Sharon A Savage 1 Keywords : cancer; cancer risk; genome-wide association study; genomics; population genetics; SNP Genetic risk of cancer Cancer is a complex, multifactorial disease with...
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From:Pharmacogenomics (Vol. 9, Issue 12) Peer-ReviewedAuthor(s): Adam JW Paige [[dagger]] 1 , Robert Brown 1 KEYWORDS: drug resistance; miRNA; polymorphisms; promoter methylation Ovarian cancer is the fourth most common tumor type in women in the UK, with...
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From:Pediatric Health (Vol. 2, Issue 2) Peer-ReviewedAuthor(s): Jan Styczynski 1 Keywords: acute lymphoblastic leukemia; acute myeloid leukemia; adults; children; individualized therapy; non-Hodgkin lymphoma; targeted therapy Definition of age groups The WHO...
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From:Personalized Medicine (Vol. 4, Issue 1) Peer-ReviewedAuthor(s): Sudhir Srivastava [[dagger]] 1 , Paul D Wagner 1 Keywords: biomarkers; cancer; oncogenes; raloxifene; risk assessment; tamoxifen; tumor suppressor genes Successful application of personalized...
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From:Pharmacogenomics (Vol. 7, Issue 1) Peer-ReviewedAuthor(s): Michael A Gordon, Ji Gil, Bo Lu, Wu Zhang, Dongyun Yang, Jim Yun, Sylke Schneider, Susan Groshen, Syma Iqbal, Oliver A Press, Katrin Rhodes, Heinz-Josef Lenz [[dagger]] Keywords : cancer;...
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From:Expert Review of Anticancer Therapy (Vol. 4, Issue 2) Peer-ReviewedResearchers at the Johns Hopkins Medical Institute (MD, USA) have discovered mutations in a gene linked to the progression of colon and other cancers. The findings may lead to the development of new therapies and...
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From:The Scientist (Vol. 17, Issue 12) Peer-ReviewedWhen good genes go bad and cancer arises, mutation normally gets the blame. But, newer evidence is challenging that one-dimensional view. Epigenetic modifications, such as DNA methylation, can also shut down tumor...
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From:Science (Vol. 274, Issue 5289) Peer-ReviewedMutations in the p53 tumor suppressor are among the most frequently observed genetic alterations in human cancer and map to the 200 -- amino acid core domain of the protein. The core domain contains the sequence-specific...
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From:PLoS ONE (Vol. 7, Issue 6) Peer-ReviewedAuthor(s): Miljana Tanic 1 , Kira Yanowsky 1 , 2 , Cristina Rodriguez-Antona 3 , Raquel Andrés 4 , Iván Márquez-Rodas 5 , Ana Osorio 1 , 2 , Javier Benitez 1 , 2 , Beatriz Martinez-Delgado 1 , 2 , * Introduction...
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From:PLoS ONE (Vol. 7, Issue 2) Peer-ReviewedAuthor(s): Stefan Bentink 1 , 6 , Benjamin Haibe-Kains 1 , 6 , Thomas Risch 1 , Jian-Bing Fan 3 , Michelle S. Hirsch 4 , 7 , Kristina Holton 1 , Renee Rubio 1 , Craig April 3 , Jing Chen 3 , Eliza Wickham-Garcia 3 ,...
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From:PLoS ONE (Vol. 7, Issue 6) Peer-ReviewedAuthor(s): Katja Hebestreit 1 , Sören Gröttrup 1 , Daniel Emden 1 , Jannis Veerkamp 1 , Christian Ruckert 1 , Hans-Ulrich Klein 1 , Carsten Müller-Tidow 2 , Martin Dugas 1 , * Introduction Recent advances in...