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From:Nature Reviews Neuroscience (Vol. 12, Issue 6) Peer-ReviewedXiong, W. et al. Nature Chem. Biol. 7, 296-303 (2011) In addition to binding to cannabinoid receptor 1 (CB1) and CB2, cannabinoids can potentiate the activity of the glycine receptor (GlyR). This study showed that...
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From:Indian Journal of Urology (Vol. 26, Issue 1) Peer-ReviewedByline: Pradeep. Tyagi, Vikas. Tyagi, Naoki. Yoshimura, Michael. Chancellor Cannabinoids, the active components of Cannabis sativa (marijuana), and their derivatives produce a wide spectrum of central and peripheral...
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From:The Scientific World Journal (Vol. 9) Peer-ReviewedActivated microglia and astrocytes produce a large number of inflammatory and neurotoxic substances in various brain pathologies, above all during neurodegenerative disorders. In the search for new neuroprotective...
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From:Nurse Practitioners' Prescribing Reference (Vol. 15, Issue 1) Peer-ReviewedMARINOL Unimed CIII Cannabinoid. Dronabinol 2.5mg, 5mg, 10mg; caps; contains sesame oil. Indications: Anorexia with weight loss in AIDS patients. Adults: Individualize. Initially 2.5mg twice daily before lunch...
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From:The Brown University Psychopharmacology Update (Vol. 22, Issue 8)The first study to examine a cannabinoid agonist for treating trichotillomania found dronabinol significantly reduced hair pulling in a small group of female subjects (mean age, 33 years). In the 12-week, open-label...
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From:Canadian Journal of Physiology and Pharmacology (Vol. 95, Issue 4) Peer-ReviewedCannabis sativa has long been used for medicinal purposes. To improve safety and efficacy, compounds from C. sativa were purified or synthesized and named under an umbrella group as cannabinoids. Currently, several...
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From:The Biological Bulletin (Vol. 202, Issue 2) Peer-Reviewed[[DELTA].sup.9]-tetrahydrocannabinol, the psychoactive ingredient of cannabis, exerts effects in humans by binding to the G-protein-coupled cannabinoid receptors [CB.sub.1] and [CB.sub.2], which are expressed in the...
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From:Science (Vol. 276, Issue 5321) Peer-ReviewedThe effects of the active ingredient of Cannabis, [[Delta].sup.9]-tetrahydrocannabinol ([[Delta].sup.9]-THC), and of the highly addictive drug heroin on in vivo dopamine transmission in the nucleus accumbens were...
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From:Analytical and Bioanalytical Chemistry (Vol. 407, Issue 3) Peer-ReviewedClandestine laboratories constantly produce new synthetic cannabinoids to circumvent legislative scheduling efforts, challenging and complicating toxicological analysis. Sundstrom et al. (Anal Bioanal Chem...
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From:Medical Cannabis and Cannabinoids (Vol. 2, Issue 1) Peer-ReviewedThe endocannabinoid system (ECS) is a multifunctional homeostatic system involved in many physiological and pathological conditions. The ligands of the ECS are the endocannabinoids, whose actions are mimicked by...
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From:Experimental Brain Research (Vol. 221, Issue 4) Peer-ReviewedWe have previously reported that a single injection of an ultra-low dose of delta-9-tetrahydrocannabinol (THC; the psychoactive ingredient of marijuana) protected the brain from pentylenentetrazole (PTZ)-induced...
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From:Obesity, Fitness & Wellness Week2020 APR 4 (NewsRx) -- By a News Reporter-Staff News Editor at Obesity, Fitness & Wellness Week -- New study results on have been published. According to news originating from the Pharmacy Department by NewsRx...
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From:Inflammatory Bowel Diseases (Vol. 25, Issue 3) Peer-ReviewedWe have read with great interest the article by Couch et al on cannabinoids and colitis. (1) The increased use of marijuana, led by its legalization and emerging data on its medical benefits, has created a unique...
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From:Neural PlasticityPeer-ReviewedEndocannabinoids are important retrograde modulators of synaptic transmission throughout the nervous system. Cannabinoid receptors are seven transmembrane G-protein coupled receptors favoring [G.sub.i/o] protein. They...
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From:BioMed Research International (Vol. 2020) Peer-ReviewedChoosing an appropriate treatment for chronic pain remains problematic, and despite the available medication for its treatment, still, many patients complain about pain and appeal to the use of cannabis derivatives for...
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From:Analytical and Bioanalytical Chemistry (Vol. 408, Issue 3) Peer-ReviewedOxysterols, ceramides, and endocannabinoids are three families of bioactive lipids suggested to be involved in obesity and metabolic syndrome. To facilitate the quantification of these potentially interconnected lipids,...
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From:Psychopharmacology (Vol. 235, Issue 8) Peer-ReviewedRationale 5F-AMB is one of the synthetic cannabinoids (SCs) designed to potentiate the ability to activate cannabinoid 1 (CB1) receptors and is abused worldwide. Although inhalation of 5F-AMB elicits serious adverse...
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From:International Journal of Molecular Sciences (Vol. 21, Issue 19) Peer-ReviewedIn recent years, Peroxisome Proliferator-Activated Receptors (PPARs) have been connected to the endocannabinoid system. These nuclear receptors indeed mediate the effects of anandamide and similar substances such as...
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From:Nature Reviews Rheumatology (Vol. 5, Issue 11) Peer-ReviewedNew research suggests that the type 1 cannabinoid receptor (CB 1) pathway has a role not only in regulating peak bone mass but also in protecting against bone loss later in life. Investigations in mice deficient for CB...
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From:Journal of Law and Health (Vol. 27, Issue 2) Peer-ReviewedI. INTRODUCTION Synthetic drugs, as opposed to naturally occurring drugs (e.g. cocaine and opium), are man-made chemical substances that are manufactured in laboratories and are designed to mimic the molecular...