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• High extracellular lactate causes reductive carboxylation in breast tissue cell lines grown under normoxic conditions

  Authors:Arthur Nathan Brodsky, Daniel C. Odenwelder, and Sarah W. HarcumFrom:PLoS ONE (Vol. 14, Issue 6) Peer-Reviewed

  June 10, 20198,998 words Report 1530LIn cancer tumors, lactate accumulation was initially attributed to high glucose consumption associated with the Warburg Effect. Now it is evident that lactate can also serve as an energy source in cancer cell...

• CHIP-ping away at tau

  Authors:Dmitry Goryunov and Ronald K.H. LiemFrom:Journal of Clinical Investigation (Vol. 117, Issue 3) Peer-Reviewed

  Mar. 20072,057 words Article 1400LProtein accumulation is a hallmark of many neurodegenerative disorders. In Alzheimer's disease (AD), a hyperphosphorylated form of the protein tau (p-tau) forms intracellular inclusions known as neurofibrillary tangles....

• Synthesis and characterization of bis(ferrocenylcarboxylato)telluranes

  Authors:Prakash C. Srivastava, Sangeeta Bajpai, Rajesh Kumar, Shikha Srivastava, Vikas Singh, Shrinkhala Dwivedi, et al.From:Canadian Journal of Chemistry (Vol. 85, Issue 7-8) Peer-Reviewed

  July-August 20073,824 words Article 1540LAbstract: A convenient route to the synthesis of the first bis(ferrocenyl carboxylato) telluranes has been developed. Reactions of 1,1,2,3,4,5,6-heptahydro-1,1-(dihydroxo)tellurane and...

• Reductive carboxylation supports growth in tumour cells with defective mitochondria

  Authors:Andrew R. Mullen, William W. Wheaton, Eunsook S. Jin, Pei-Hsuan Chen, Lucas B. Sullivan, Tzuling Cheng, et al.From:Nature (Vol. 481, Issue 7381) Peer-Reviewed

  Jan. 19, 20124,543 words Report 1430LMitochondrial metabolism provides precursors to build macromolecules in growing cancer cells (1,2). In normally functioning tumour cell mitochondria, oxidative metabolism of glucose- and glutamine-derived carbon...

• Carbon dioxide utilization via carbonate-promoted C-H carboxylation

  Authors:Aanindeeta Banerjee, Graham R. Dick, Tatsuhiko Yoshino, and Matthew W. KananFrom:Nature (Vol. 531, Issue 7593) Peer-Reviewed

  Mar. 10, 20167,507 words Article 1440LUsing carbon dioxide (C[O.sub.2]) as a feedstock for commodity synthesis is an attractive means of reducing greenhouse gas emissions and a possible stepping-stone towards renewable synthetic fuels (1,2). A major...

• Guest-Host Chemistry with Dendrimers-Binding of Carboxylates in Aqueous Solution

  Authors:Mario Ficker, Johannes F. Petersen, Jon S. Hansen, and Jorn B. ChristensenFrom:PLoS ONE (Vol. 10, Issue 10) Peer-Reviewed

  Oct. 8, 20154,715 words Report 1510LRecognition and binding of anions in water is difficult due to the ability of water molecules to form strong hydrogen bonds and to solvate the anions. The complexation of two different carboxylates with...

• Enantioselective fluorescent sensors for chiral carboxylates based on BINOL--synthesis and chiral recognition

  Authors:Kuo-xi Xu, Yu-xia Wang, Shu-yan Jiao, Jin Zhao, and Chao-jie WangFrom:Canadian Journal of Chemistry (Vol. 88, Issue 4) Peer-Reviewed

  Apr. 20104,798 words Report The four novel derivatives of 1,1'-bi-2-naphihol (BINOL) have been prepared, and the structures of these compounds have been characterized by IR, MS, [sup.1]H and [sup.13]C NMR spectroscopy, and elemental analysis. The...

• CIC Medal award lecture--molecular keystones: lessons from bioorganic reaction mechanisms (1)

  Author:Ronald KlugerFrom:Canadian Journal of Chemistry (Vol. 84, Issue 9) Peer-Reviewed

  Sept. 20066,794 words Article 1410LAbstract: The work of the author is reviewed in terms of "keystone molecules" that serve as figurative points of support to understand the interactions of smaller molecules within biological macromolecules. The review...

• Reductive carboxylation supports redox homeostasis during anchorage-independent growth

  Authors:Lei Jiang, Alexander A. Shestov, Pamela Swain, Chendong Yang, Seth J. Parker, Qiong A. Wang, et al.From:Nature (Vol. 532, Issue 7598) Peer-Reviewed

  Apr. 14, 20165,001 words Report 1440LCells receive growth and survival stimuli through their attachment to an extracellular matrix (ECM) (1). Overcoming the addiction to ECM-induced signals is required for anchorage-independent growth, a property of most...

• Remote carboxylation of halogenated aliphatic hydrocarbons with carbon dioxide

  Authors:Francisco Juli-Hernndez, Toni Moragas, Josep Cornella, and Ruben MartinFrom:Nature (Vol. 545, Issue 7652) Peer-Reviewed

  May 4, 20173,137 words Report 1720LAuthor(s): Francisco Juli-Hernndez [1]; Toni Moragas [1]; Josep Cornella [1]; Ruben Martin (corresponding author) [1, 2] Catalytic carboncarbon bond formation has enabled the streamlining of synthetic routes when...

• Amine-decorated nanocrystalline cellulose surfaces: synthesis, characterization, and surface properties

  Authors:Usha D. Hemraz, Yaman Boluk, and Rajesh SunaseeFrom:Canadian Journal of Chemistry (Vol. 91, Issue 10) Peer-Reviewed

  Oct. 20135,343 words Report 1610LIn this present work, terminal amino-functionalized nanocrystalline cellulose derivatives were prepared using a simple two-step protecting group-free protocol under aqueous reaction conditions at room temperature....

• A new approach to coupled two-phase reactive transport simulation for long-term degradation of concrete

  Authors:Yonghui Huang, Haibing Shao, Erich Wieland, Olaf Kolditz, and Georg KosakowskiFrom:Construction and Building Materials (Vol. 190) Peer-Reviewed

  Nov. 30, 201814,740 words Report 1440LABSTRACT We present a new model for fast and efficient simulation of long-term concrete degradation due to alkali-silica reaction (ASR) and carbonation. The novel model provides an alternative coupling solution of...

• Expression of organic anion transporting polypeptide 1c1 and monocarboxylate transporter 8 in the rat placental barrier and the compensatory response to thyroid dysfunction

  Authors:Yi-na Sun, Yuan-jun Liu, Lu Zhang, Yan Ye, Lai-xiang Lin, Yong-mei Li, et al.From:PLoS ONE (Vol. 9, Issue 4) Peer-Reviewed

  Apr. 20147,517 words Report 1530LThyroid hormones (THs) must pass from mother to fetus for normal fetal development and require the expression of placental TH transporters. We investigate the compensatory effect of placental organic anion transporting...